DOI: 10.7554/elife.32723. TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes

TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes

10.7554/elife.32723

Crossref journal-article

eLife Sciences Publications, Ltd

eLife (4374)

Abstract

Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen? TANGO1 is known to form a ring that corrals COPII coats, and we show here how this ring or fence is assembled. Our data reveal that a TANGO1 ring is organized by its radial interaction with COPII, and lateral interactions with cTAGE5, TANGO1-short or itself. Of particular interest is the finding that TANGO1 recruits ERGIC membranes for collagen export via the NRZ (NBAS/RINT1/ZW10) tether complex. Therefore, TANGO1 couples retrograde membrane flow to anterograde cargo transport. Without the NRZ complex, the TANGO1 ring does not assemble, suggesting its role in nucleating or stabilising this process. Thus, coordinated capture of COPII coats, cTAGE5, TANGO1-short, and tethers by TANGO1 assembles a collagen export machine at the ER.

Bibliography

Raote, I., Ortega-Bellido, M., Santos, A. J., Foresti, O., Zhang, C., Garcia-Parajo, M. F., Campelo, F., & Malhotra, V. (2018). TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes. ELife, 7. CLOCKSS.

Authors 8

Ishier Raote (first)
Maria Ortega-Bellido (additional)
António JM Santos (additional)
Ombretta Foresti (additional)
Chong Zhang (additional)
Maria F Garcia-Parajo (additional)
Felix Campelo (additional)
Vivek Malhotra (additional)

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Dates

Type	When
Created	7 years, 5 months ago (March 7, 2018, 8 a.m.)
Deposited	1 year, 10 months ago (Oct. 11, 2023, 8:50 p.m.)
Indexed	3 days, 5 hours ago (Aug. 23, 2025, 1:16 a.m.)
Issued	7 years, 5 months ago (March 7, 2018)
Published	7 years, 5 months ago (March 7, 2018)
Published Online	7 years, 5 months ago (March 7, 2018)

Funders 13

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BibTeX

@article{Raote_2018, title={TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes}, volume={7}, ISSN={2050-084X}, url={http://dx.doi.org/10.7554/elife.32723}, DOI={10.7554/elife.32723}, journal={eLife}, publisher={eLife Sciences Publications, Ltd}, author={Raote, Ishier and Ortega-Bellido, Maria and Santos, António JM and Foresti, Ombretta and Zhang, Chong and Garcia-Parajo, Maria F and Campelo, Felix and Malhotra, Vivek}, year={2018}, month=mar }

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  "abstract": "<jats:p>Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen? TANGO1 is known to form a ring that corrals COPII coats, and we show here how this ring or fence is assembled. Our data reveal that a TANGO1 ring is organized by its radial interaction with COPII, and lateral interactions with cTAGE5, TANGO1-short or itself. Of particular interest is the finding that TANGO1 recruits ERGIC membranes for collagen export via the NRZ (NBAS/RINT1/ZW10) tether complex. Therefore, TANGO1 couples retrograde membrane flow to anterograde cargo transport. Without the NRZ complex, the TANGO1 ring does not assemble, suggesting its role in nucleating or stabilising this process. Thus, coordinated capture of COPII coats, cTAGE5, TANGO1-short, and tethers by TANGO1 assembles a collagen export machine at the ER.</jats:p>",
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