DOI: 10.4049/jimmunol.177.12.8708. Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor

Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor
10.4049/jimmunol.177.12.8708
Crossref journal-article
Oxford University Press (OUP)
The Journal of Immunology (286)
Abstract
Abstract TLR are evolutionarily conserved molecules that play a key role in the initiation of innate antimicrobial immune responses. Through their influence on dendritic cell maturation, these receptors are also thought to indirectly shape the adaptive immune response. However, no data are currently available regarding both TLR expression and function in human CD8+ T cell subsets. We report that a subpopulation of CD8+ T cells, i.e., effector, but neither naive nor central memory cells, constitutively expresses TLR3. Moreover, the ligation of the receptor by a specific agonist in TLR3-expressing CD8+ T cells increased IFN-γ secretion induced by TCR-dependent and -independent stimulation, without affecting proliferation or specific cytolytic activity. These results thereby suggest that TLR3 ligands can not only indirectly influence the adaptive immune response through modulation of dendritic cell activation, but also directly increase IFN-γ production by Ag-specific CD8+ T cells. Altogether, the present work might open new perspectives for the use of TLR ligands as adjuvants for immunotherapy.
Bibliography
Tabiasco, J., DeveÌvre, E., Rufer, N., Salaun, B., Cerottini, J.-C., Speiser, D., & Romero, P. (2006). Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor. The Journal of Immunology, 177(12), 8708â8713.
Authors 7
Julie Tabiasco (first)
Estelle Devêvre (additional)
Nathalie Rufer (additional)
Bruno Salaun (additional)
Jean-Charles Cerottini (additional)
Daniel Speiser (additional)
Pedro Romero (additional)
References 51 Referenced 106
Dates
Type	When
Created	11 years, 4 months ago (April 18, 2014, 6:56 p.m.)
Deposited	7 months, 4 weeks ago (Jan. 2, 2025, 12:44 p.m.)
Indexed	2 months, 2 weeks ago (June 13, 2025, 10:21 p.m.)
Issued	18 years, 8 months ago (Dec. 15, 2006)
Published	18 years, 8 months ago (Dec. 15, 2006)
Published Print	18 years, 8 months ago (Dec. 15, 2006)
Funders 0
None
BibTeX
@article{Tabiasco_2006, title={Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor}, volume={177}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.177.12.8708}, DOI={10.4049/jimmunol.177.12.8708}, number={12}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Tabiasco, Julie and Devêvre, Estelle and Rufer, Nathalie and Salaun, Bruno and Cerottini, Jean-Charles and Speiser, Daniel and Romero, Pedro}, year={2006}, month=dec, pages={8708–8713} }
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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>TLR are evolutionarily conserved molecules that play a key role in the initiation of innate antimicrobial immune responses. Through their influence on dendritic cell maturation, these receptors are also thought to indirectly shape the adaptive immune response. However, no data are currently available regarding both TLR expression and function in human CD8+ T cell subsets. We report that a subpopulation of CD8+ T cells, i.e., effector, but neither naive nor central memory cells, constitutively expresses TLR3. Moreover, the ligation of the receptor by a specific agonist in TLR3-expressing CD8+ T cells increased IFN-\u03b3 secretion induced by TCR-dependent and -independent stimulation, without affecting proliferation or specific cytolytic activity. These results thereby suggest that TLR3 ligands can not only indirectly influence the adaptive immune response through modulation of dendritic cell activation, but also directly increase IFN-\u03b3 production by Ag-specific CD8+ T cells. Altogether, the present work might open new perspectives for the use of TLR ligands as adjuvants for immunotherapy.</jats:p>",
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