DOI: 10.4049/jimmunol.176.4.2095. Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus [Penn]

Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus
10.4049/jimmunol.176.4.2095
Crossref journal-article
Oxford University Press (OUP)
The Journal of Immunology (286)
Abstract
Abstract Increased monocyte/macrophage (Mφ) apoptosis occurs in patients with systemic lupus erythematosus (SLE) and is mediated, at least in part, by an autoreactive CD4+ T cell subset. Furthermore, autoreactive murine CD4+ T cells that kill syngeneic Mφ in vitro induce a lupus-like disease in vivo. However, it is unclear whether increased Mφ apoptosis in SLE per se is sufficient to accelerate/promote autoimmunity. We have investigated whether increased Mφ apoptosis in vivo, induced by the administration of clodronate liposomes, can exacerbate the autoimmune phenotype in NZB × SWR (SNF1) lupus-prone mice, and induce autoantibody production in haplotype-matched BALB/c × DBA1 (DBF1) non-lupus-prone mice. Lupus-prone mice SNF1 mice that were treated with clodronate liposomes, but not mice treated with vehicle, developed significant increases in autoantibodies to dsDNA, nucleosomes, and the idiotypically related family of nephritic Abs IdLNF1, when compared with untreated SNF1 mice. Furthermore, clodronate treatment hastened the onset of proteinuria and worsened SNF1 lupus nephritis. When compared with vehicle-treated controls, clodronate-treated non-lupus-prone DBF1 mice developed significantly higher levels of anti-nucleosome and IdLNF1 Abs but did not develop lupus nephritis. We propose that Mφ apoptosis contributes to the pathogenesis of autoantibody formation and organ damage through both an increase in the apoptotic load and impairment in the clearance of apoptotic material. This study suggests that mechanisms that induce scavenger cell apoptosis, such as death induced by autoreactive cytotoxic T cells observed in SLE, could play a pathogenic role and contribute to the severity of the disease.
Bibliography
Denny, M. F., Chandaroy, P., Killen, P. D., Caricchio, R., Lewis, E. E., Richardson, B. C., Lee, K.-D., Gavalchin, J., & Kaplan, M. J. (2006). Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus. The Journal of Immunology, 176(4), 2095â2104.
Authors 9
Michael F. Denny (first)
Parthapratim Chandaroy (additional)
Paul D. Killen (additional)
Roberto Caricchio (additional)
Emily E. Lewis (additional)
Bruce C. Richardson (additional)
Kyung-Dall Lee (additional)
Jerrie Gavalchin (additional)
Mariana J. Kaplan (additional)
References 88 Referenced 107
Dates
Type	When
Created	11 years, 4 months ago (April 20, 2014, 8:31 p.m.)
Deposited	7 months, 4 weeks ago (Jan. 2, 2025, 12:22 p.m.)
Indexed	2 months, 1 week ago (June 17, 2025, 6:50 a.m.)
Issued	19 years, 6 months ago (Feb. 15, 2006)
Published	19 years, 6 months ago (Feb. 15, 2006)
Published Print	19 years, 6 months ago (Feb. 15, 2006)
Funders 0
None
BibTeX
@article{Denny_2006, title={Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus}, volume={176}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.176.4.2095}, DOI={10.4049/jimmunol.176.4.2095}, number={4}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Denny, Michael F. and Chandaroy, Parthapratim and Killen, Paul D. and Caricchio, Roberto and Lewis, Emily E. and Richardson, Bruce C. and Lee, Kyung-Dall and Gavalchin, Jerrie and Kaplan, Mariana J.}, year={2006}, month=feb, pages={2095–2104} }
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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Increased monocyte/macrophage (M\u03c6) apoptosis occurs in patients with systemic lupus erythematosus (SLE) and is mediated, at least in part, by an autoreactive CD4+ T cell subset. Furthermore, autoreactive murine CD4+ T cells that kill syngeneic M\u03c6 in vitro induce a lupus-like disease in vivo. However, it is unclear whether increased M\u03c6 apoptosis in SLE per se is sufficient to accelerate/promote autoimmunity. We have investigated whether increased M\u03c6 apoptosis in vivo, induced by the administration of clodronate liposomes, can exacerbate the autoimmune phenotype in NZB \u00d7 SWR (SNF1) lupus-prone mice, and induce autoantibody production in haplotype-matched BALB/c \u00d7 DBA1 (DBF1) non-lupus-prone mice. Lupus-prone mice SNF1 mice that were treated with clodronate liposomes, but not mice treated with vehicle, developed significant increases in autoantibodies to dsDNA, nucleosomes, and the idiotypically related family of nephritic Abs IdLNF1, when compared with untreated SNF1 mice. Furthermore, clodronate treatment hastened the onset of proteinuria and worsened SNF1 lupus nephritis. When compared with vehicle-treated controls, clodronate-treated non-lupus-prone DBF1 mice developed significantly higher levels of anti-nucleosome and IdLNF1 Abs but did not develop lupus nephritis. We propose that M\u03c6 apoptosis contributes to the pathogenesis of autoantibody formation and organ damage through both an increase in the apoptotic load and impairment in the clearance of apoptotic material. This study suggests that mechanisms that induce scavenger cell apoptosis, such as death induced by autoreactive cytotoxic T cells observed in SLE, could play a pathogenic role and contribute to the severity of the disease.</jats:p>",
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  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        2,
        15
      ]
    ]
  },
  "references-count": 88,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2006,
          2,
          15
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.4049/jimmunol.176.4.2095",
  "relation": {},
  "ISSN": [
    "0022-1767",
    "1550-6606"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2006,
        2,
        15
      ]
    ]
  }
}