DOI: 10.4049/jimmunol.171.2.515. Cutting Edge: Granzymes A and B Are Not Essential for Perforin-Mediated Tumor Rejection

Cutting Edge: Granzymes A and B Are Not Essential for Perforin-Mediated Tumor Rejection

10.4049/jimmunol.171.2.515

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractControversy still exists regarding the biological function of granzyme serine proteases released with perforin from the cytotoxic granules of NK cells and CTLs. In particular, it is not clear whether the major granzymes, A and B, play an essential role in tumor rejection mediated by the perforin pathway. We have now examined the relative importance of perforin and granzyme A and B clusters in five different tumor models that stringently distinguish their importance. We conclude that granzyme A and B clusters are not essential for CTL- and NK cell-mediated rejection of spontaneous and experimental tumors, raising the likelihood that either perforin alone or in combination with an additional granzyme or granule component(s) mediates cytotoxicity of tumor cells in vivo.

Bibliography

Smyth, M. J., Street, S. E. A., & Trapani, J. A. (2003). Cutting Edge: Granzymes A and B Are Not Essential for Perforin-Mediated Tumor Rejection. The Journal of Immunology, 171(2), 515â518.

Authors 3

Mark J. Smyth (first)
Shayna E. A. Street (additional)
Joseph A. Trapani (additional)

References 36 Referenced 76

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 7:29 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 1:57 p.m.)
Indexed	2 months, 1 week ago (June 27, 2025, 10:43 a.m.)
Issued	22 years, 1 month ago (July 15, 2003)
Published	22 years, 1 month ago (July 15, 2003)
Published Print	22 years, 1 month ago (July 15, 2003)

Funders 0

None

BibTeX

@article{Smyth_2003, title={Cutting Edge: Granzymes A and B Are Not Essential for Perforin-Mediated Tumor Rejection}, volume={171}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.171.2.515}, DOI={10.4049/jimmunol.171.2.515}, number={2}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Smyth, Mark J. and Street, Shayna E. A. and Trapani, Joseph A.}, year={2003}, month=jul, pages={515–518} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>Controversy still exists regarding the biological function of granzyme serine proteases released with perforin from the cytotoxic granules of NK cells and CTLs. In particular, it is not clear whether the major granzymes, A and B, play an essential role in tumor rejection mediated by the perforin pathway. We have now examined the relative importance of perforin and granzyme A and B clusters in five different tumor models that stringently distinguish their importance. We conclude that granzyme A and B clusters are not essential for CTL- and NK cell-mediated rejection of spontaneous and experimental tumors, raising the likelihood that either perforin alone or in combination with an additional granzyme or granule component(s) mediates cytotoxicity of tumor cells in vivo.</jats:p>",
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