DOI: 10.4049/jimmunol.171.11.6039. NK Cells Respond to Pulmonary Infection with <i>Mycobacterium tuberculosis</i>, but Play a Minimal Role in Protection

NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection

10.4049/jimmunol.171.11.6039

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Both innate and adaptive immune systems contribute to host defense against infection with Mycobacterium tuberculosis. NK cells have been associated with early resistance against intracellular pathogens and are known to be potent producers of the cytokine IFN-γ. In C57BL/6 mice infected by aerosol exposure with M. tuberculosis, NK cells increased in the lungs over the first 21 days of infection. Expansion of the NK cell subset was associated with increased expression of activation and maturation markers. In addition, NK cells isolated from the infected lungs were capable of producing IFN-γ and became positive for perforin. In vivo depletion of NK cells using a lytic Ab had no influence on bacterial load within the lungs. These findings indicate that NK cells can become activated during the early response to pulmonary tuberculosis in the mouse model and are a source of IFN-γ, but their removal does not substantially alter the expression of host resistance.

Bibliography

Junqueira-Kipnis, A. P., Kipnis, A., Jamieson, A., Juarrero, M. G., Diefenbach, A., Raulet, D. H., Turner, J., & Orme, I. M. (2003). NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection. The Journal of Immunology, 171(11), 6039â6045.

Authors 8

Ana Paula Junqueira-Kipnis (first)
Andre Kipnis (additional)
Amanda Jamieson (additional)
Mercedes Gonzalez Juarrero (additional)
Andreas Diefenbach (additional)
David H. Raulet (additional)
Joanne Turner (additional)
Ian M. Orme (additional)

References 40 Referenced 135

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 9:32 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 12:17 p.m.)
Indexed	2 days, 21 hours ago (Sept. 3, 2025, 5:57 a.m.)
Issued	21 years, 9 months ago (Dec. 1, 2003)
Published	21 years, 9 months ago (Dec. 1, 2003)
Published Print	21 years, 9 months ago (Dec. 1, 2003)

Funders 0

None

BibTeX

@article{Junqueira_Kipnis_2003, title={NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection}, volume={171}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.171.11.6039}, DOI={10.4049/jimmunol.171.11.6039}, number={11}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Junqueira-Kipnis, Ana Paula and Kipnis, Andre and Jamieson, Amanda and Juarrero, Mercedes Gonzalez and Diefenbach, Andreas and Raulet, David H. and Turner, Joanne and Orme, Ian M.}, year={2003}, month=dec, pages={6039–6045} }

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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Both innate and adaptive immune systems contribute to host defense against infection with Mycobacterium tuberculosis. NK cells have been associated with early resistance against intracellular pathogens and are known to be potent producers of the cytokine IFN-\u03b3. In C57BL/6 mice infected by aerosol exposure with M. tuberculosis, NK cells increased in the lungs over the first 21 days of infection. Expansion of the NK cell subset was associated with increased expression of activation and maturation markers. In addition, NK cells isolated from the infected lungs were capable of producing IFN-\u03b3 and became positive for perforin. In vivo depletion of NK cells using a lytic Ab had no influence on bacterial load within the lungs. These findings indicate that NK cells can become activated during the early response to pulmonary tuberculosis in the mouse model and are a source of IFN-\u03b3, but their removal does not substantially alter the expression of host resistance.</jats:p>",
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    "date-time": "2025-01-02T17:17:53Z",
    "timestamp": 1735838273000
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  "resource": {
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      "URL": "https://journals.aai.org/jimmunol/article/171/11/6039/35971/NK-Cells-Respond-to-Pulmonary-Infection-with"
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  "ISSN": [
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}