DOI: 10.4049/jimmunol.169.6.2846. Cutting Edge: <i>Salmonella</i> AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway

Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway

10.4049/jimmunol.169.6.2846

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Secreted prokaryotic effector proteins have evolved to modulate the cellular functions of specific eukaryotic hosts. Generally, these proteins are considered virulence factors that facilitate parasitism. However, in certain plant and insect eukaryotic/prokaryotic relationships, effector proteins are involved in the establishment of commensal or symbiotic interactions. In this study, we report that the AvrA protein from Salmonella typhimurium, a common enteropathogen of humans, is an effector molecule that inhibits activation of the key proinflammatory NF-κB transcription factor and augments apoptosis in human epithelial cells. This activity is similar but mechanistically distinct from that described for YopJ, an AvrA homolog expressed by the bacterial pathogen Yersinia. We suggest that AvrA may limit virulence in vertebrates in a manner analogous to avirulence factors in plants, and as such, is the first bacterial effector from a mammalian pathogen that has been ascribed such a function.

Bibliography

Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z. Q., Chen, H., Madara, J. L., Orth, K., & Neish, A. S. (2002). Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-ÎºB Pathway. The Journal of Immunology, 169(6), 2846â2850.

Authors 9

Lauren S. Collier-Hyams (first)
Hui Zeng (additional)
Jun Sun (additional)
Amelia D. Tomlinson (additional)
Zhao Qin Bao (additional)
Huaqun Chen (additional)
James L. Madara (additional)
Kim Orth (additional)
Andrew S. Neish (additional)

References 23 Referenced 241

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 9:59 p.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 1:41 p.m.)
Indexed	1 week, 1 day ago (Aug. 19, 2025, 6:06 a.m.)
Issued	22 years, 11 months ago (Sept. 15, 2002)
Published	22 years, 11 months ago (Sept. 15, 2002)
Published Print	22 years, 11 months ago (Sept. 15, 2002)

Funders 0

None

BibTeX

@article{Collier_Hyams_2002, title={Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway}, volume={169}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.169.6.2846}, DOI={10.4049/jimmunol.169.6.2846}, number={6}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Collier-Hyams, Lauren S. and Zeng, Hui and Sun, Jun and Tomlinson, Amelia D. and Bao, Zhao Qin and Chen, Huaqun and Madara, James L. and Orth, Kim and Neish, Andrew S.}, year={2002}, month=sep, pages={2846–2850} }

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