DOI: 10.4049/jimmunol.168.12.6294. Characterization of Mouse and Human B7-H3 Genes

Characterization of Mouse and Human B7-H3 Genes

10.4049/jimmunol.168.12.6294

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract T cell activation and immune function are regulated by costimulatory molecules of the B7 superfamily. Human B7-H3 is a recent addition to this family and has been shown to mediate T cell proliferation and IFN-γ production. In this work we describe the identification of the mouse B7-H3 homolog, which is ubiquitously expressed in a variety of tissues. Activated CD4 and CD8 T cells express a putative receptor that can be recognized by soluble mouse B7-H3-Ig molecules. While the mouse B7-H3 gene was found to contain a single copy, we discovered a novel isoform of human B7-H3 (named as B7-H3b hereafter) with four Ig-like domains that results from gene duplication and differential splicing. B7-H3b is the major isoform expressed in several tissues. This structural information suggests a genetic variation of the B7-H3 gene in mammalian species.

Bibliography

Sun, M., Richards, S., Prasad, D. V. R., Mai, X. M., Rudensky, A., & Dong, C. (2002). Characterization of Mouse and Human B7-H3 Genes. The Journal of Immunology, 168(12), 6294â6297.

Authors 6

Mingyi Sun (first)
Sabrina Richards (additional)
Durbaka V. R. Prasad (additional)
Xoi Muoi Mai (additional)
Alexander Rudensky (additional)
Chen Dong (additional)

References 17 Referenced 236

Dates

Type	When
Created	11 years, 4 months ago (April 22, 2014, 10:38 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 12:39 p.m.)
Indexed	1 month, 2 weeks ago (July 19, 2025, 11:34 p.m.)
Issued	23 years, 2 months ago (June 15, 2002)
Published	23 years, 2 months ago (June 15, 2002)
Published Print	23 years, 2 months ago (June 15, 2002)

Funders 0

None

BibTeX

@article{Sun_2002, title={Characterization of Mouse and Human B7-H3 Genes}, volume={168}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.168.12.6294}, DOI={10.4049/jimmunol.168.12.6294}, number={12}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Sun, Mingyi and Richards, Sabrina and Prasad, Durbaka V. R. and Mai, Xoi Muoi and Rudensky, Alexander and Dong, Chen}, year={2002}, month=jun, pages={6294–6297} }

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