DOI: 10.4049/jimmunol.167.9.5209. The Vesicular Stomatitis Virus Matrix Protein Inhibits Glycoprotein 130-Dependent STAT Activation

The Vesicular Stomatitis Virus Matrix Protein Inhibits Glycoprotein 130-Dependent STAT Activation

10.4049/jimmunol.167.9.5209

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractInfection of cells by vesicular stomatitis virus (VSV) results in the inhibition of host transcription. We show in this study that infection of HeLa cells with VSV leads to a strongly diminished activation of STAT3 and STAT1 by the inflammatory cytokine IL-6. This effect was mimicked by forced expression of a single viral protein, the matrix (M)-protein of VSV, which blocked STAT activation via chimeric receptors containing the cytoplasmic domain of the IL-6 signal transducer gp130. Western blot analysis revealed that VSV M-protein did not inhibit the nuclear translocation of activated STAT3 but did inhibit its tyrosine phosphorylation. Inhibition of STAT activation was not dependent on tyrosine 759 of the IL-6 signal transducer gp130, suggesting that the inhibitory action of VSV M-protein is not mediated by the induction of the suppressor of cytokine signaling 3. VSV M-protein inhibited gene transcription from cotransfected α2-macroglobulin or antichymotrypsin promoter/luciferase reporter constructs which contain STAT3-binding sites. However, transcription from a STAT5-dependent construct was not negatively affected. In conclusion, our data suggest that infection by VSV and specifically overexpression of the viral M-protein interferes with an important signaling pathway necessary for triggering antiviral and inflammatory responses.

Bibliography

Terstegen, L., Gatsios, P., Ludwig, S., Pleschka, S., Jahnen-Dechent, W., Heinrich, P. C., & Graeve, L. (2001). The Vesicular Stomatitis Virus Matrix Protein Inhibits Glycoprotein 130-Dependent STAT Activation. The Journal of Immunology, 167(9), 5209â5216.

Authors 7

Lara Terstegen (first)
Petros Gatsios (additional)
Stephan Ludwig (additional)
Stephan Pleschka (additional)
Willi Jahnen-Dechent (additional)
Peter C. Heinrich (additional)
Lutz Graeve (additional)

References 49 Referenced 13

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 11:19 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 2:04 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 7, 2025, 4:34 p.m.)
Issued	23 years, 10 months ago (Nov. 1, 2001)
Published	23 years, 10 months ago (Nov. 1, 2001)
Published Print	23 years, 10 months ago (Nov. 1, 2001)

Funders 0

None

BibTeX

@article{Terstegen_2001, title={The Vesicular Stomatitis Virus Matrix Protein Inhibits Glycoprotein 130-Dependent STAT Activation}, volume={167}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.167.9.5209}, DOI={10.4049/jimmunol.167.9.5209}, number={9}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Terstegen, Lara and Gatsios, Petros and Ludwig, Stephan and Pleschka, Stephan and Jahnen-Dechent, Willi and Heinrich, Peter C. and Graeve, Lutz}, year={2001}, month=nov, pages={5209–5216} }

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