DOI: 10.4049/jimmunol.167.11.6441. Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes

Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes
10.4049/jimmunol.167.11.6441
Crossref journal-article
Oxford University Press (OUP)
The Journal of Immunology (286)
Abstract
Abstract Signal sequences of human MHC class I molecules are a unique source of epitopes for newly synthesized nonclassical HLA-E molecules. Binding of such conserved peptides to HLA-E induces its cell surface expression and protects cells from NK cell attack. After cleavage from the pre-protein, we show that the liberated MHC class I signal peptide is further processed by signal peptide peptidase in the hydrophobic, membrane-spanning region. This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum via the TAP.
Bibliography
Lemberg, M. K., Bland, F. A., Weihofen, A., Braud, V. M., & Martoglio, B. (2001). Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes. The Journal of Immunology, 167(11), 6441â6446.
Authors 5
Marius K. Lemberg (first)
Felicity A. Bland (additional)
Andreas Weihofen (additional)
Veronique M. Braud (additional)
Bruno Martoglio (additional)
References 47 Referenced 154
Dates
Type	When
Created	11 years, 4 months ago (April 20, 2014, 8:08 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 12:19 p.m.)
Indexed	3 months ago (June 3, 2025, 5:03 a.m.)
Issued	23 years, 9 months ago (Dec. 1, 2001)
Published	23 years, 9 months ago (Dec. 1, 2001)
Published Print	23 years, 9 months ago (Dec. 1, 2001)
Funders 0
None
BibTeX
@article{Lemberg_2001, title={Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes}, volume={167}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.167.11.6441}, DOI={10.4049/jimmunol.167.11.6441}, number={11}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Lemberg, Marius K. and Bland, Felicity A. and Weihofen, Andreas and Braud, Veronique M. and Martoglio, Bruno}, year={2001}, month=dec, pages={6441–6446} }
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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Signal sequences of human MHC class I molecules are a unique source of epitopes for newly synthesized nonclassical HLA-E molecules. Binding of such conserved peptides to HLA-E induces its cell surface expression and protects cells from NK cell attack. After cleavage from the pre-protein, we show that the liberated MHC class I signal peptide is further processed by signal peptide peptidase in the hydrophobic, membrane-spanning region. This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum via the TAP.</jats:p>",
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