DOI: 10.4049/jimmunol.167.10.5767. Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis

Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis

10.4049/jimmunol.167.10.5767

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractIn a search for genes expressed by dendritic cells (DC), we have cloned cDNAs encoding different forms of an asialoglycoprotein receptor (ASGPR). The DC-ASGPR represents long and short isoforms of human macrophage lectin, a Ca2+-dependent type II transmembrane lectin displaying considerable homology with the H1 and H2 subunits of the hepatic ASGPR. Immunoprecipitation from DC using an anti-DC-ASGPR mAb yielded a major 40-kDa protein with an isoelectric point of 8.2. DC-ASGPR mRNA was observed predominantly in immune tissues. Both isoforms were detected in DC and granulocytes, but not in T, B, or NK cells, or monocytes. DC-ASGPR species were restricted to the CD14-derived DC obtained from CD34+ progenitors, while absent from the CD1a-derived subset. Accordingly, both monocyte-derived DC and tonsillar interstitial-type DC expressed DC-ASGPR protein, while Langerhans-type cells did not. Furthermore, DC-ASGPR is a feature of immaturity, as expression was lost upon CD40 activation. In agreement with the presence of tyrosine-based and dileucine motifs in the intracytoplasmic domain, mAb against DC-ASGPR was rapidly internalized by DC at 37°C. Finally, intracellular DC-ASGPR was localized to early endosomes, suggesting that the receptor recycles to the cell surface following internalization of ligand. Our findings identify DC-ASGPR/human macrophage lectin as a feature of immature DC, and as another lectin important for the specialized Ag-capture function of DC.

Bibliography

Valladeau, J., Duvert-Frances, V., Pin, J.-J., Kleijmeer, M. J., Ait-Yahia, S., Ravel, O., Vincent, C., Vega, F., Helms, A., Gorman, D., Zurawski, S. M., Zurawski, G., Ford, J., & Saeland, S. (2001). Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis. The Journal of Immunology, 167(10), 5767â5774.

Authors 14

Jenny Valladeau (first)
Valérie Duvert-Frances (additional)
Jean-Jacques Pin (additional)
Monique J. Kleijmeer (additional)
Smina Ait-Yahia (additional)
Odile Ravel (additional)
Claude Vincent (additional)
Felix Vega (additional)
Alison Helms (additional)
Dan Gorman (additional)
Sandra M. Zurawski (additional)
Gerard Zurawski (additional)
John Ford (additional)
Sem Saeland (additional)

References 52 Referenced 94

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 10:55 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 1:40 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 7, 2025, 4:30 p.m.)
Issued	23 years, 9 months ago (Nov. 15, 2001)
Published	23 years, 9 months ago (Nov. 15, 2001)
Published Print	23 years, 9 months ago (Nov. 15, 2001)

Funders 0

None

BibTeX

@article{Valladeau_2001, title={Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis}, volume={167}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.167.10.5767}, DOI={10.4049/jimmunol.167.10.5767}, number={10}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Valladeau, Jenny and Duvert-Frances, Valérie and Pin, Jean-Jacques and Kleijmeer, Monique J. and Ait-Yahia, Smina and Ravel, Odile and Vincent, Claude and Vega, Felix and Helms, Alison and Gorman, Dan and Zurawski, Sandra M. and Zurawski, Gerard and Ford, John and Saeland, Sem}, year={2001}, month=nov, pages={5767–5774} }

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