DOI: 10.4049/jimmunol.166.2.1314. Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis [Penn]

10.4049/jimmunol.166.2.1314

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractTRAIL, the TNF-related apoptosis-inducing ligand, induces apoptosis of tumor cells, but not normal cells; the roles of TRAIL in nontransformed tissues are unknown. Using a soluble TRAIL receptor, we examined the consequences of TRAIL blockade in an animal model of multiple sclerosis. We found that chronic TRAIL blockade in mice exacerbated experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein. The exacerbation was evidenced primarily by increases in disease score and degree of inflammation in the CNS. Interestingly, the degree of apoptosis of inflammatory cells in the CNS was not affected by TRAIL blockade, suggesting that TRAIL may not regulate apoptosis of inflammatory cells in experimental autoimmune encephalomyelitis. By contrast, myelin oligodendrocyte glycoprotein-specific Th1 and Th2 cell responses were significantly enhanced in animals treated with the soluble TRAIL receptor. Based on these observations, we conclude that unlike TNF, which promotes autoimmune inflammation, TRAIL inhibits autoimmune encephalomyelitis and prevents activation of autoreactive T cells.

Bibliography

Hilliard, B., Wilmen, A., Seidel, C., Liu, T.-S. T., GoÌke, R., & Chen, Y. (2001). Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis. The Journal of Immunology, 166(2), 1314â1319.

Authors 6

Brendan Hilliard (first)
Andreas Wilmen (additional)
Cheryl Seidel (additional)
Tzu-Shang T. Liu (additional)
Rüdiger Göke (additional)
Youhai Chen (additional)

References 47 Referenced 158

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 10:56 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 1:55 p.m.)
Indexed	4 months, 3 weeks ago (April 9, 2025, 12:10 p.m.)
Issued	24 years, 7 months ago (Jan. 15, 2001)
Published	24 years, 7 months ago (Jan. 15, 2001)
Published Print	24 years, 7 months ago (Jan. 15, 2001)

Funders 0

None

BibTeX

@article{Hilliard_2001, title={Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis}, volume={166}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.166.2.1314}, DOI={10.4049/jimmunol.166.2.1314}, number={2}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Hilliard, Brendan and Wilmen, Andreas and Seidel, Cheryl and Liu, Tzu-Shang T. and Göke, Rüdiger and Chen, Youhai}, year={2001}, month=jan, pages={1314–1319} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>TRAIL, the TNF-related apoptosis-inducing ligand, induces apoptosis of tumor cells, but not normal cells; the roles of TRAIL in nontransformed tissues are unknown. Using a soluble TRAIL receptor, we examined the consequences of TRAIL blockade in an animal model of multiple sclerosis. We found that chronic TRAIL blockade in mice exacerbated experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein. The exacerbation was evidenced primarily by increases in disease score and degree of inflammation in the CNS. Interestingly, the degree of apoptosis of inflammatory cells in the CNS was not affected by TRAIL blockade, suggesting that TRAIL may not regulate apoptosis of inflammatory cells in experimental autoimmune encephalomyelitis. By contrast, myelin oligodendrocyte glycoprotein-specific Th1 and Th2 cell responses were significantly enhanced in animals treated with the soluble TRAIL receptor. Based on these observations, we conclude that unlike TNF, which promotes autoimmune inflammation, TRAIL inhibits autoimmune encephalomyelitis and prevents activation of autoreactive T cells.</jats:p>",
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