DOI: 10.4049/jimmunol.165.9.4910. Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes

Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes

10.4049/jimmunol.165.9.4910

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractDendritic cells (DCs) exhibit considerable heterogeneity in their anatomical location, surface phenotype, and functional properties. In this study, we demonstrate that peripheral lymph nodes contain at least four major, functionally separable, and independently derived, DC subsets, which can be clearly demarcated by their CD11c, CD40, and CD8 expression pattern. Surprisingly, all DCs derived directly from the bone marrow, the myeloid- and the lymphoid-related subsets, turned over fast with t1/2 of a couple of days. In contrast, DCs exported from the skin, both dermal and epidermal, accumulated 3- to 4-fold slower, turnover that is dramatically increased by cutaneous inflammation.

Bibliography

Ruedl, C., Koebel, P., Bachmann, M., Hess, M., & Karjalainen, K. (2000). Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes. The Journal of Immunology, 165(9), 4910â4916.

Authors 5

Christiane Ruedl (first)
Pascale Koebel (additional)
Martin Bachmann (additional)
Michael Hess (additional)
Klaus Karjalainen (additional)

References 43 Referenced 159

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 10:59 p.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 12:26 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 7, 2025, 5:01 a.m.)
Issued	24 years, 9 months ago (Nov. 1, 2000)
Published	24 years, 9 months ago (Nov. 1, 2000)
Published Print	24 years, 9 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{Ruedl_2000, title={Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes}, volume={165}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.165.9.4910}, DOI={10.4049/jimmunol.165.9.4910}, number={9}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Ruedl, Christiane and Koebel, Pascale and Bachmann, Martin and Hess, Michael and Karjalainen, Klaus}, year={2000}, month=nov, pages={4910–4916} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>Dendritic cells (DCs) exhibit considerable heterogeneity in their anatomical location, surface phenotype, and functional properties. In this study, we demonstrate that peripheral lymph nodes contain at least four major, functionally separable, and independently derived, DC subsets, which can be clearly demarcated by their CD11c, CD40, and CD8 expression pattern. Surprisingly, all DCs derived directly from the bone marrow, the myeloid- and the lymphoid-related subsets, turned over fast with t1/2 of a couple of days. In contrast, DCs exported from the skin, both dermal and epidermal, accumulated 3- to 4-fold slower, turnover that is dramatically increased by cutaneous inflammation.</jats:p>",
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