DOI: 10.4049/jimmunol.165.9.4848. T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo

T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo

10.4049/jimmunol.165.9.4848

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractWe recently described a new population of CD4+ regulatory T cells (Tr1) that inhibits proliferative responses of bystander T cells and prevents colitis induction in vivo through the secretion of IL-10. IL-10, which had been primarily described as a Th2-specific cytokine inhibiting Th1 responses, has displayed in several models a more general immune suppression on both types of effector T cell responses. Using an immediate hypersensitivity model in which BALB/c mice immunized with OVA (alum) normally generate Th2-dominated responses, we examined the ability of OVA-specific Tr1 T cell clones to inhibit OVA-specific cytokines and Ab responses. In contrast to Th2 or Th1 T cell clones, transfer of Tr1 T cell clones coincident with OVA immunization inhibited Ag-specific serum IgE responses, whereas IgG1 and IgG2a synthesis were not affected. This specific inhibition was mediated in part through IL-10 secretion as anti-IL-10 receptor Abs treatment reverted the inhibitory effect of Tr1 T cell clones. Although specifically targeted to IgE responses, Tr1 clones’ inhibitory effects were more profound as they affected Ag-specific Th2 cell priming both in term of proliferative responses and cytokine secretion. These results suggest that regulatory T cells may play a fundamental role in maintaining the balance of the immune system to prevent allergic disorders.

Bibliography

Cottrez, F., Hurst, S. D., Coffman, R. L., & Groux, H. (2000). T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo. The Journal of Immunology, 165(9), 4848â4853.

Authors 4

Françoise Cottrez (first)
Steven D. Hurst (additional)
Robert L. Coffman (additional)
Hervé Groux (additional)

References 37 Referenced 282

Dates

Type	When
Created	11 years, 4 months ago (April 20, 2014, 10:59 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 1:40 p.m.)
Indexed	2 months, 1 week ago (June 27, 2025, 9:05 p.m.)
Issued	24 years, 10 months ago (Nov. 1, 2000)
Published	24 years, 10 months ago (Nov. 1, 2000)
Published Print	24 years, 10 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{Cottrez_2000, title={T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo}, volume={165}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.165.9.4848}, DOI={10.4049/jimmunol.165.9.4848}, number={9}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Cottrez, Françoise and Hurst, Steven D. and Coffman, Robert L. and Groux, Hervé}, year={2000}, month=nov, pages={4848–4853} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>We recently described a new population of CD4+ regulatory T cells (Tr1) that inhibits proliferative responses of bystander T cells and prevents colitis induction in vivo through the secretion of IL-10. IL-10, which had been primarily described as a Th2-specific cytokine inhibiting Th1 responses, has displayed in several models a more general immune suppression on both types of effector T cell responses. Using an immediate hypersensitivity model in which BALB/c mice immunized with OVA (alum) normally generate Th2-dominated responses, we examined the ability of OVA-specific Tr1 T cell clones to inhibit OVA-specific cytokines and Ab responses. In contrast to Th2 or Th1 T cell clones, transfer of Tr1 T cell clones coincident with OVA immunization inhibited Ag-specific serum IgE responses, whereas IgG1 and IgG2a synthesis were not affected. This specific inhibition was mediated in part through IL-10 secretion as anti-IL-10 receptor Abs treatment reverted the inhibitory effect of Tr1 T cell clones. Although specifically targeted to IgE responses, Tr1 clones\u2019 inhibitory effects were more profound as they affected Ag-specific Th2 cell priming both in term of proliferative responses and cytokine secretion. These results suggest that regulatory T cells may play a fundamental role in maintaining the balance of the immune system to prevent allergic disorders.</jats:p>",
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