DOI: 10.4049/jimmunol.164.4.1741. CD27-Mediated Activation of Murine NK Cells

CD27-Mediated Activation of Murine NK Cells

10.4049/jimmunol.164.4.1741

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract CD27, a member of the TNF receptor superfamily, has been implicated in T cell activation, T cell development, and T cell-dependent Ab production by B cells. In the present study we examined the expression and function of CD27 on murine NK cells. Murine NK cells constitutively expressed CD27 on their surface. Stimulation with immobilized anti-CD27 mAb or murine CD27 ligand (CD70) transfectans solely could induce proliferation and IFN-γ production of freshly isolated NK cells and enhanced the proliferation and IFN-γ production of anti-NK1.1-sutimulated NK cells. Although NK cell cytotoxicity was not triggered by anti-CD27 mAb or against CD70 transfectants, prestimulation via CD27 enhanced the cytotoxic activity of NK cells in an IFN-γ-dependent manner. These results suggest that CD27-mediated activation may be involved in the NK cell-mediated innate immunity against virus-infected or transformed cells expressing CD70.

Bibliography

Takeda, K., Oshima, H., Hayakawa, Y., Akiba, H., Atsuta, M., Kobata, T., Kobayashi, K., Ito, M., Yagita, H., & Okumura, K. (2000). CD27-Mediated Activation of Murine NK Cells. The Journal of Immunology, 164(4), 1741â1745.

Authors 10

Kazuyoshi Takeda (first)
Hideo Oshima (additional)
Yoshihiro Hayakawa (additional)
Hisaya Akiba (additional)
Machiko Atsuta (additional)
Tetsuji Kobata (additional)
Kimio Kobayashi (additional)
Mamoru Ito (additional)
Hideo Yagita (additional)
Ko Okumura (additional)

References 40 Referenced 108

Dates

Type	When
Created	11 years, 4 months ago (April 22, 2014, 2:44 p.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 11:58 a.m.)
Indexed	1 week, 3 days ago (Aug. 19, 2025, 7 a.m.)
Issued	25 years, 6 months ago (Feb. 15, 2000)
Published	25 years, 6 months ago (Feb. 15, 2000)
Published Print	25 years, 6 months ago (Feb. 15, 2000)

Funders 0

None

BibTeX

@article{Takeda_2000, title={CD27-Mediated Activation of Murine NK Cells}, volume={164}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.164.4.1741}, DOI={10.4049/jimmunol.164.4.1741}, number={4}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Takeda, Kazuyoshi and Oshima, Hideo and Hayakawa, Yoshihiro and Akiba, Hisaya and Atsuta, Machiko and Kobata, Tetsuji and Kobayashi, Kimio and Ito, Mamoru and Yagita, Hideo and Okumura, Ko}, year={2000}, month=feb, pages={1741–1745} }

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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>CD27, a member of the TNF receptor superfamily, has been implicated in T cell activation, T cell development, and T cell-dependent Ab production by B cells. In the present study we examined the expression and function of CD27 on murine NK cells. Murine NK cells constitutively expressed CD27 on their surface. Stimulation with immobilized anti-CD27 mAb or murine CD27 ligand (CD70) transfectans solely could induce proliferation and IFN-\u03b3 production of freshly isolated NK cells and enhanced the proliferation and IFN-\u03b3 production of anti-NK1.1-sutimulated NK cells. Although NK cell cytotoxicity was not triggered by anti-CD27 mAb or against CD70 transfectants, prestimulation via CD27 enhanced the cytotoxic activity of NK cells in an IFN-\u03b3-dependent manner. These results suggest that CD27-mediated activation may be involved in the NK cell-mediated innate immunity against virus-infected or transformed cells expressing CD70.</jats:p>",
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