DOI: 10.4049/jimmunol.163.5.2382. Cutting Edge: Inflammatory Signaling by <i>Borrelia burgdorferi</i> Lipoproteins Is Mediated by Toll-Like Receptor 2

Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2

10.4049/jimmunol.163.5.2382

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The agent of Lyme disease, Borrelia burgdorferi, produces membrane lipoproteins possessing potent inflammatory properties linked to disease pathology. The recent association of toll-like receptors (TLR) 2 and 4 with LPS responses prompted the examination of TLR involvement in lipoprotein signaling. The ability of human cell lines to respond to lipoproteins was correlated with the expression of TLR2. Transfection of TLR2 into cell lines conferred responsiveness to lipoproteins, lipopeptides, and sonicated B. burgdorferi, as measured by nuclear translocation of NF-κB and cytokine production. The physiological importance of this interaction was demonstrated by the 10-fold greater sensitivity of TLR2-transfected cells to lipoproteins than LPS. Futhermore, TLR2-dependant signaling by lipoproteins was facilitated by CD14. These data indicate that TLR2 facilitates the inflammatory events associated with Lyme arthritis. In addition, the widespread expression of lipoproteins by other bacterial species suggests that this interaction may have broad implications in microbial inflammation and pathogenesis.

Bibliography

Hirschfeld, M., Kirschning, C. J., Schwandner, R., Wesche, H., Weis, J. H., Wooten, R. M., & Weis, J. J. (1999). Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2. The Journal of Immunology, 163(5), 2382â2386.

Authors 7

Matthew Hirschfeld (first)
Carsten J Kirschning (additional)
Ralf Schwandner (additional)
Holger Wesche (additional)
John H Weis (additional)
R Mark Wooten (additional)
Janis J Weis (additional)

References 35 Referenced 514

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{'first-page': '4584', 'volume-title': 'Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-κB and inflammatory activation in human endothelial cells. J. Immunol.', 'year': '1996', 'key': '2025032909154804800_R6'} / Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-κB and inflammatory activation in human endothelial cells. J. Immunol. (1996)
{'first-page': '3663', 'volume-title': 'Infect. Immun.', 'year': '1994', 'key': '2025032909154804800_R7'} / Infect. Immun. (1994)
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Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 11:06 a.m.)
Deposited	5 months ago (March 31, 2025, 8:43 a.m.)
Indexed	4 hours, 31 minutes ago (Sept. 3, 2025, 7:16 a.m.)
Issued	26 years ago (Sept. 1, 1999)
Published	26 years ago (Sept. 1, 1999)
Published Online	26 years ago (Sept. 1, 1999)
Published Print	26 years ago (Sept. 1, 1999)

Funders 0

None

BibTeX

@article{Hirschfeld_1999, title={Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2}, volume={163}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.163.5.2382}, DOI={10.4049/jimmunol.163.5.2382}, number={5}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Hirschfeld, Matthew and Kirschning, Carsten J and Schwandner, Ralf and Wesche, Holger and Weis, John H and Wooten, R Mark and Weis, Janis J}, year={1999}, month=sep, pages={2382–2386} }

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