DOI: 10.4049/jimmunol.163.3.1490. Cellular Immune Responses Are Essential for the Development of <i>Helicobacter felis</i>-Associated Gastric Pathology

Cellular Immune Responses Are Essential for the Development of Helicobacter felis-Associated Gastric Pathology

10.4049/jimmunol.163.3.1490

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The bacteria Helicobacter pylori is a major human pathogen that infects over half of the world’s population. Infection initiates a series of changes in the gastric mucosa, beginning with atrophic gastritis and leading in some patients to peptic ulcer disease, mucosa-associated lymphomas, and gastric adenocarcinoma. Although this cascade of events clearly occurs, little is known about the role of the host immune response in disease progression. We have utilized the C57BL/6 Helicobacter felis mouse model to critically analyze the role of the adaptive immune response in the development of Helicobacter-associated gastric pathology. Infection of B and T cell-deficient RAG-1−/− mice or T cell-deficient TCRβδ−/− mice with H. felis resulted in high levels of colonization, but no detectable gastric pathology. Conversely, infection of B cell-deficient μMT mice resulted in severe gastric alterations identical with those seen in immunocompetent C57BL/6-infected mice, including gastric mucosal hyperplasia and intestinal metaplasia. These results demonstrate that the host T cell response is a critical mediator of Helicobacter-associated gastric pathology, and that B cells and their secreted Abs are not the effectors of the immune-mediated gastric pathology seen after H. felis infection. These results indicate that in addition to specific Helicobacter virulence factors, the host immune response is an important determinant of Helicobacter-associated disease.

Bibliography

Roth, K. A., Kapadia, S. B., Martin, S. M., & Lorenz, R. G. (1999). Cellular Immune Responses Are Essential for the Development of Helicobacter felis-Associated Gastric Pathology. The Journal of Immunology, 163(3), 1490â1497.

Authors 4

Kevin A. Roth (first)
Sharookh B. Kapadia (additional)
Steven M. Martin (additional)
Robin G. Lorenz (additional)

References 51 Referenced 147

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 11:09 a.m.)
Deposited	8 months ago (Jan. 2, 2025, 11:48 a.m.)
Indexed	2 days, 3 hours ago (Sept. 3, 2025, 6:02 a.m.)
Issued	26 years, 1 month ago (Aug. 1, 1999)
Published	26 years, 1 month ago (Aug. 1, 1999)
Published Print	26 years, 1 month ago (Aug. 1, 1999)

Funders 0

None

BibTeX

@article{Roth_1999, title={Cellular Immune Responses Are Essential for the Development of Helicobacter felis-Associated Gastric Pathology}, volume={163}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.163.3.1490}, DOI={10.4049/jimmunol.163.3.1490}, number={3}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Roth, Kevin A. and Kapadia, Sharookh B. and Martin, Steven M. and Lorenz, Robin G.}, year={1999}, month=aug, pages={1490–1497} }

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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>The bacteria Helicobacter pylori is a major human pathogen that infects over half of the world\u2019s population. Infection initiates a series of changes in the gastric mucosa, beginning with atrophic gastritis and leading in some patients to peptic ulcer disease, mucosa-associated lymphomas, and gastric adenocarcinoma. Although this cascade of events clearly occurs, little is known about the role of the host immune response in disease progression. We have utilized the C57BL/6 Helicobacter felis mouse model to critically analyze the role of the adaptive immune response in the development of Helicobacter-associated gastric pathology. Infection of B and T cell-deficient RAG-1\u2212/\u2212 mice or T cell-deficient TCR\u03b2\u03b4\u2212/\u2212 mice with H. felis resulted in high levels of colonization, but no detectable gastric pathology. Conversely, infection of B cell-deficient \u03bcMT mice resulted in severe gastric alterations identical with those seen in immunocompetent C57BL/6-infected mice, including gastric mucosal hyperplasia and intestinal metaplasia. These results demonstrate that the host T cell response is a critical mediator of Helicobacter-associated gastric pathology, and that B cells and their secreted Abs are not the effectors of the immune-mediated gastric pathology seen after H. felis infection. These results indicate that in addition to specific Helicobacter virulence factors, the host immune response is an important determinant of Helicobacter-associated disease.</jats:p>",
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