DOI: 10.4049/jimmunol.163.3.1350. Multiple Deficiencies Underlie NK Cell Inactivity in Lymphotoxin-α Gene-Targeted Mice

Multiple Deficiencies Underlie NK Cell Inactivity in Lymphotoxin-α Gene-Targeted Mice

10.4049/jimmunol.163.3.1350

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractWe have evaluated the NK cell antitumor activity in lymphotoxin (LT)-deficient mice. Both NK cell-mediated tumor rejection and protection from experimental metastases were significantly compromised in LT-α-deficient mice. Analysis of LT-α-deficient mice revealed that the absolute number of αβTCR− NK1.1+ NK cells was reduced in bone marrow and thymus, but with overall proportional decreases in other hemopoietic organs. In addition, the antitumor potential of αβTCR− NK1.1+ cells, as determined by their lytic capacity and perforin expression, was reduced 1.5- to 3-fold in LT-α-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-α-deficient mice.

Bibliography

Smyth, M. J., Johnstone, R. W., Cretney, E., Haynes, N. M., Sedgwick, J. D., Korner, H., Poulton, L. D., & Baxter, A. G. (1999). Multiple Deficiencies Underlie NK Cell Inactivity in Lymphotoxin-Î± Gene-Targeted Mice. The Journal of Immunology, 163(3), 1350â1353.

Authors 8

Mark J. Smyth (first)
Ricky W. Johnstone (additional)
Erika Cretney (additional)
Nicole M. Haynes (additional)
Jonathon D. Sedgwick (additional)
Heiner Korner (additional)
Lynn D. Poulton (additional)
Alan G. Baxter (additional)

References 28 Referenced 36

Dates

Type	When
Created	2 years, 7 months ago (Dec. 31, 2022, 10:31 a.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 12:50 p.m.)
Indexed	2 months ago (June 25, 2025, 3:16 a.m.)
Issued	26 years ago (Aug. 1, 1999)
Published	26 years ago (Aug. 1, 1999)
Published Print	26 years ago (Aug. 1, 1999)

Funders 0

None

BibTeX

@article{Smyth_1999, title={Multiple Deficiencies Underlie NK Cell Inactivity in Lymphotoxin-α Gene-Targeted Mice}, volume={163}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.163.3.1350}, DOI={10.4049/jimmunol.163.3.1350}, number={3}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Smyth, Mark J. and Johnstone, Ricky W. and Cretney, Erika and Haynes, Nicole M. and Sedgwick, Jonathon D. and Korner, Heiner and Poulton, Lynn D. and Baxter, Alan G.}, year={1999}, month=aug, pages={1350–1353} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>We have evaluated the NK cell antitumor activity in lymphotoxin (LT)-deficient mice. Both NK cell-mediated tumor rejection and protection from experimental metastases were significantly compromised in LT-\u03b1-deficient mice. Analysis of LT-\u03b1-deficient mice revealed that the absolute number of \u03b1\u03b2TCR\u2212 NK1.1+ NK cells was reduced in bone marrow and thymus, but with overall proportional decreases in other hemopoietic organs. In addition, the antitumor potential of \u03b1\u03b2TCR\u2212 NK1.1+ cells, as determined by their lytic capacity and perforin expression, was reduced 1.5- to 3-fold in LT-\u03b1-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-\u03b1-deficient mice.</jats:p>",
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