DOI: 10.4049/jimmunol.162.3.1851. CD1 Expression by Dendritic Cells in Human Leprosy Lesions: Correlation with Effective Host Immunity

CD1 Expression by Dendritic Cells in Human Leprosy Lesions: Correlation with Effective Host Immunity

10.4049/jimmunol.162.3.1851

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractA potential role for the CD1 family of lipid Ag-presenting molecules in antimicrobial immunity in vivo was investigated in human leprosy skin lesions. Strong induction of three CD1 proteins (CD1a, -b, and -c) was observed in dermal granulomas in biopsy samples of involved skin from patients with the tuberculoid form of leprosy or with reversal reactions, which represent clinical patterns of disease associated with active cellular immunity to Mycobacterium leprae. In contrast, lesions from patients with the lepromatous form of the disease who lack effective cell-mediated immunity to the pathogen did not show induction of CD1 proteins. Thus, expression of CD1 correlated directly with effective immunity to M. leprae, as assessed by the clinical course of infection. CD1a, -b, and -c could be induced to similar levels on monocytes from the blood of either tuberculoid or lepromatous leprosy patients. This suggested that the absence of expression in lepromatous lesions was most likely due to local factors at the site of infection as opposed to a primary defect of the CD1 system itself. The majority of cells expressing CD1 in leprosy lesions were identified as a population of CD83+ dendritic cells. Initial in vitro studies of the Ag-presenting function of CD1+CD83+ monocyte-derived dendritic cells showed that such cells were highly efficient APCs for CD1-restricted T cells. These results indicate that the CD1 system can be up-regulated in human infectious diseases in vivo, and may play a role in augmenting host defense against microbial pathogens.

Bibliography

Sieling, P. A., Jullien, D., Dahlem, M., Tedder, T. F., Rea, T. H., Modlin, R. L., & Porcelli, S. A. (1999). CD1 Expression by Dendritic Cells in Human Leprosy Lesions: Correlation with Effective Host Immunity. The Journal of Immunology, 162(3), 1851â1858.

Authors 7

Peter A. Sieling (first)
Denis Jullien (additional)
Monica Dahlem (additional)
Thomas F. Tedder (additional)
Thomas H. Rea (additional)
Robert L. Modlin (additional)
Steven A. Porcelli (additional)

References 41 Referenced 151

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 9:47 a.m.)
Deposited	8 months ago (Jan. 2, 2025, 11:30 a.m.)
Indexed	2 months ago (July 2, 2025, 11 a.m.)
Issued	26 years, 7 months ago (Feb. 1, 1999)
Published	26 years, 7 months ago (Feb. 1, 1999)
Published Print	26 years, 7 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Sieling_1999, title={CD1 Expression by Dendritic Cells in Human Leprosy Lesions: Correlation with Effective Host Immunity}, volume={162}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.162.3.1851}, DOI={10.4049/jimmunol.162.3.1851}, number={3}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Sieling, Peter A. and Jullien, Denis and Dahlem, Monica and Tedder, Thomas F. and Rea, Thomas H. and Modlin, Robert L. and Porcelli, Steven A.}, year={1999}, month=feb, pages={1851–1858} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>A potential role for the CD1 family of lipid Ag-presenting molecules in antimicrobial immunity in vivo was investigated in human leprosy skin lesions. Strong induction of three CD1 proteins (CD1a, -b, and -c) was observed in dermal granulomas in biopsy samples of involved skin from patients with the tuberculoid form of leprosy or with reversal reactions, which represent clinical patterns of disease associated with active cellular immunity to Mycobacterium leprae. In contrast, lesions from patients with the lepromatous form of the disease who lack effective cell-mediated immunity to the pathogen did not show induction of CD1 proteins. Thus, expression of CD1 correlated directly with effective immunity to M. leprae, as assessed by the clinical course of infection. CD1a, -b, and -c could be induced to similar levels on monocytes from the blood of either tuberculoid or lepromatous leprosy patients. This suggested that the absence of expression in lepromatous lesions was most likely due to local factors at the site of infection as opposed to a primary defect of the CD1 system itself. The majority of cells expressing CD1 in leprosy lesions were identified as a population of CD83+ dendritic cells. Initial in vitro studies of the Ag-presenting function of CD1+CD83+ monocyte-derived dendritic cells showed that such cells were highly efficient APCs for CD1-restricted T cells. These results indicate that the CD1 system can be up-regulated in human infectious diseases in vivo, and may play a role in augmenting host defense against microbial pathogens.</jats:p>",
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      "doi-asserted-by": "crossref",
      "unstructured": "Martin, L. H., F. Calabi, F.-A. Lefebvre, C. A. G. Bilsland, C. Milstein. 1987. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. Proc. Natl. Acad. Sci. USA\u200884: 9189",
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      "DOI": "10.1073/pnas.84.24.9189"
    },
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      "doi-asserted-by": "crossref",
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      "DOI": "10.1016/S0065-2776(08)60629-X"
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      "unstructured": "Zeng, Z., A. R. Castano, B. W. Segelke, E. A. Stura, P. A. Peterson, I. A. Wilson. 1997. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science\u2008277: 339",
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    },
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      "DOI": "10.1038/360593a0"
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      "unstructured": "Beckman, E. M., S. A. Porcelli, C. T. Morita, S. M. Behar, S. T. Furlong, M. B. Brenner. 1994. Recognition of a lipid antigen by CD1-restricted \u03b1\u03b2+ T cells. Nature\u2008372: 691",
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      "DOI": "10.1038/372691a0"
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      "DOI": "10.1126/science.278.5336.283"
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      "key": "2022123114360383200_R9",
      "DOI": "10.1126/science.278.5343.1626"
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      "DOI": "10.1016/S0167-5699(98)01289-4"
    },
    {
      "unstructured": "Ridley, D. S., W. H. Jopling. 1966. Classification of leprosy according to immunity: a five-group system. Int. J. Lepr. Other Mycobact. Dis.\u200834: 255",
      "key": "2022123114360383200_R11"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Panchamoorthy, G., J. McClean, R. L. Modlin, C. T. Morita, S. Ishikawa, M. B. Brenner, H. Band. 1991. A predominance of the T cell receptor V\u03b32/V\u03b42 subset in human mycobacteria-responsive T cells suggests germline encoded recognition. J. Immunol.\u2008147: 3360",
      "key": "2022123114360383200_R12",
      "DOI": "10.4049/jimmunol.147.10.3360"
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    {
      "doi-asserted-by": "crossref",
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      "key": "2022123114360383200_R13",
      "DOI": "10.1073/pnas.77.3.1588"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Olive, D., P. Dubreuil, C. Mawas. 1984. Two distinct TL-like molecular subsets defined by monoclonal antibodies on the surface of human thymocytes with different expression on leukemia lines. Immunogenetics\u200820: 253",
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      "DOI": "10.1007/BF00364207"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Brodsky, F. M., P. Parham. 1982. Monomorphic anti-HLA-A,B,C monoclonal antibodies detecting molecular subunits and combinatorial determinants. J. Immunol.\u2008128: 129",
      "key": "2022123114360383200_R15",
      "DOI": "10.4049/jimmunol.128.1.129"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Zhou, L.-J., T. F. Tedder. 1996. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl. Acad. Sci. USA\u200893: 2588",
      "key": "2022123114360383200_R16",
      "DOI": "10.1073/pnas.93.6.2588"
    },
    {
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      "unstructured": "Kasinrerk, W., T. Baumruker, O. Majdic, W. Knapp, H. Stockinger. 1993. CD1 molecule expression on human monocytes induced by granulocyte-macrophage colony-stimulating factor. J. Immunol.\u2008150: 579",
      "key": "2022123114360383200_R17",
      "DOI": "10.4049/jimmunol.150.2.579"
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    {
      "doi-asserted-by": "crossref",
      "unstructured": "Roncarolo, M.-G., H. Yssel, J.-L. Touraine, R. Bacchetta, L. Gebuhrer, J. deVries, H. Spits. 1988. Antigen recognition by MHC-incompatible cells of a human mismatched chimera. J. Exp. Med.\u2008168: 2152",
      "key": "2022123114360383200_R18",
      "DOI": "10.1084/jem.168.6.2139"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Nestle, F. O., X. G. Zheng, C. B. Thompson, L. A. Turka, B. J. Nickoloff. 1993. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J. Immunol.\u2008151: 6535",
      "key": "2022123114360383200_R19",
      "DOI": "10.4049/jimmunol.151.11.6535"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Fithian, E., S. Kung, G. Goldstein, M. Rubenfeld, C. Fenoglio, R. Edelson. 1981. Reactivity of Langerhans cells with hybridoma antibody. Proc. Natl. Acad. Sci. USA\u200878: 2541",
      "key": "2022123114360383200_R20",
      "DOI": "10.1073/pnas.78.4.2541"
    },
    {
      "unstructured": "Barnetson, R. S., G. Bjune, J. M. H. Pearson, G. Kronvall. 1976. Cell mediated and humoral immunity in \u201creversal reactions.\u201d. Int. J. Lepr. Other Mycobact. Dis.\u200844: 267",
      "key": "2022123114360383200_R21"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Zhou, L.-J., T. F. Tedder. 1995. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol.\u2008154: 3821",
      "key": "2022123114360383200_R22",
      "DOI": "10.4049/jimmunol.154.8.3821"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Sallusto, F., A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor \u03b1. J. Exp. Med.\u2008179: 1109",
      "key": "2022123114360383200_R23",
      "DOI": "10.1084/jem.179.4.1109"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Porcelli, S. A., C. T. Morita, R. L. Modlin. 1996. T-cell recognition of non-peptide antigens. Curr. Opin. Immunol.\u20088: 510",
      "key": "2022123114360383200_R24",
      "DOI": "10.1016/S0952-7915(96)80039-2"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, R. L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science\u2008254: 277",
      "key": "2022123114360383200_R25",
      "DOI": "10.1126/science.254.5029.277"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Yamamura, M., X.-H. Wang, J. D. Ohmen, K. Uyemura, T. H. Rea, B. R. Bloom, R. L. Modlin. 1992. Cytokine patterns of immunologically mediated tissue damage. J. Immunol.\u2008149: 1470",
      "key": "2022123114360383200_R26",
      "DOI": "10.4049/jimmunol.149.4.1470"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Thomssen, H., M. Kahan, M. Londei. 1995. Differential effects of interleukin-10 on the expression of HLA class II and CD1 molecules induced by granulocyte/macrophage colony-stimulating factor/interleukin-4. Eur. J. Immunol.\u200825: 2465",
      "key": "2022123114360383200_R27",
      "DOI": "10.1002/eji.1830250909"
    },
    {
      "unstructured": "Collings, L. A., N. Tidman, L. W. Poulter. 1985. Quantitation of HLA-DR expression by cells involved in the skin lesions of tuberculoid and lepromatous leprosy. Clin. Exp. Immunol.\u200861: 58",
      "key": "2022123114360383200_R28"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Van Voorhis, W. C., G. Kaplan, E. N. Sarno, M. A. Horwitz, R. M. Steinman, W. R. Levis, N. Nogueira, L. S. Hair, C. R. Gattass, B. A. Arrick, Z. A. Cohn. 1982. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. N. Engl. J. Med.\u2008307: 1593",
      "key": "2022123114360383200_R29",
      "DOI": "10.1056/NEJM198212233072601"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Modlin, R. L., F. M. Hofman, C. R. Taylor, T. H. Rea. 1983. T lymphocyte subsets in the skin lesions of patients with leprosy. J. Am. Acad. Dermatol.\u20088: 182",
      "key": "2022123114360383200_R30",
      "DOI": "10.1016/S0190-9622(83)70021-6"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Steinman, R. M.. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol.\u200811: 271",
      "key": "2022123114360383200_R31",
      "DOI": "10.1146/annurev.iy.09.040191.001415"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Reis e Sousa, C., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R. N. Germain, A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin-12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med.\u2008186: 1819",
      "key": "2022123114360383200_R32",
      "DOI": "10.1084/jem.186.11.1819"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Zhou, L.-J., T. F. Tedder. 1995. A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood\u200886: 3295",
      "key": "2022123114360383200_R33",
      "DOI": "10.1182/blood.V86.9.3295.bloodjournal8693295"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Barnes, P. F., D. Chatterjee, J. S. Abrams, S. Lu, E. Wang, M. Yamamura, P. J. Brennan, R. L. Modlin. 1992. Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan: relationship to chemical structure. J. Immunol.\u2008149: 541",
      "key": "2022123114360383200_R34",
      "DOI": "10.4049/jimmunol.149.2.541"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Barnes, P. F., D. Chatterjee, P. J. Brennan, T. H. Rea, R. L. Modlin. 1992. TNF production in patients with leprosy. Infect. Immun.\u200860: 1441",
      "key": "2022123114360383200_R35",
      "DOI": "10.1128/iai.60.4.1441-1446.1992"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Henderson, R. A., S. C. Watkins, J. L. Flynn. 1997. Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J. Immunol.\u2008159: 635",
      "key": "2022123114360383200_R36",
      "DOI": "10.4049/jimmunol.159.2.635"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Stenger, S., K. R. Niazi, R. L. Modlin. 1998. Down-regulation of CD1 expression on antigen-presenting cells by infection with Mycobacterium tuberculosis. J. Immunol.\u2008161: 3582",
      "key": "2022123114360383200_R37",
      "DOI": "10.4049/jimmunol.161.7.3582"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Sugita, M., R. M. Jackman, E. van Donselaar, S. M. Behar, R. A. Rogers, P. J. Peters, M. B. Brenner, S. A. Porcelli. 1996. Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs. Science\u2008273: 349",
      "key": "2022123114360383200_R38",
      "DOI": "10.1126/science.273.5273.349"
    },
    {
      "doi-asserted-by": "crossref",
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      "key": "2022123114360383200_R39",
      "DOI": "10.1016/S1074-7613(00)80539-7"
    },
    {
      "doi-asserted-by": "crossref",
      "unstructured": "Lotteau, V., L. Teyton, A. Peleraux, L. Nilsson, L. Karlsson, V. Schmid, V. Quaranta, P. A. Peterson. 1990. Nature. Nature\u2008348: 600",
      "key": "2022123114360383200_R40",
      "DOI": "10.1038/348600a0"
    },
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      "key": "2022123114360383200_R41",
      "DOI": "10.1126/science.276.5319.1684"
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