DOI: 10.4049/jimmunol.161.7.3271. Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes

10.4049/jimmunol.161.7.3271

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractMouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. α-Galactosylceramide (α-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells. Moreover, splenic T cells derived from mCD1-deficient mice were not stimulated by α-GalCer, suggesting that the responsive T cells are selected by mCD1. Using cytoflow techniques, we confirmed that, in response to α-GalCer, IFN-γ-secreting cells displayed an NK T cell phenotype. The predominance of IFN-γ vs IL-4, however, is determined by the type of mCD1+ APC, suggesting the potential for APC regulation of cytokine production by NK T cells. Among a panel of 10 mCD1-autoreactive T cell hybridomas, only the ones that express the typical Vα14Jα281 TCR rearrangement of NK T cells responded to α-GalCer. Fixation or treatment of mCD1+ APCs with an inhibitor of endosomal acidification and the use of mCD1 mutants unable to traffic through endosome still allowed α-GalCer to stimulate NK T cells. Thus, endosomal trafficking and Ag processing are not required for glycolipid recognition. In summary, α-GalCer might be the autologous ligand, or a mimic of a glycolipid ligand, involved in the mCD1-mediated stimulation of NK T cells.

Bibliography

Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998). Selective Ability of Mouse CD1 to Present Glycolipids: Î±-Galactosylceramide Specifically Stimulates VÎ±14+ NK T Lymphocytes. The Journal of Immunology, 161(7), 3271â3281.

Authors 9

Nicolas Burdin (first)
Laurent Brossay (additional)
Yasuhiko Koezuka (additional)
Stephen T. Smiley (additional)
Michael J. Grusby (additional)
Ming Gui (additional)
Masaru Taniguchi (additional)
Kyoko Hayakawa (additional)
Mitchell Kronenberg (additional)

References 65 Referenced 310

Dates

Type	When
Created	2 years, 7 months ago (Dec. 30, 2022, 4:15 p.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 12:32 p.m.)
Indexed	1 month ago (July 23, 2025, 8:08 a.m.)
Issued	26 years, 10 months ago (Oct. 1, 1998)
Published	26 years, 10 months ago (Oct. 1, 1998)
Published Print	26 years, 10 months ago (Oct. 1, 1998)

Funders 0

None

BibTeX

@article{Burdin_1998, title={Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes}, volume={161}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.161.7.3271}, DOI={10.4049/jimmunol.161.7.3271}, number={7}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Burdin, Nicolas and Brossay, Laurent and Koezuka, Yasuhiko and Smiley, Stephen T. and Grusby, Michael J. and Gui, Ming and Taniguchi, Masaru and Hayakawa, Kyoko and Kronenberg, Mitchell}, year={1998}, month=oct, pages={3271–3281} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        23
      ]
    ],
    "date-time": "2025-07-23T12:08:58Z",
    "timestamp": 1753272538000,
    "version": "3.32.0"
  },
  "reference-count": 65,
  "publisher": "Oxford University Press (OUP)",
  "issue": "7",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        10,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. \u03b1-Galactosylceramide (\u03b1-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells. Moreover, splenic T cells derived from mCD1-deficient mice were not stimulated by \u03b1-GalCer, suggesting that the responsive T cells are selected by mCD1. Using cytoflow techniques, we confirmed that, in response to \u03b1-GalCer, IFN-\u03b3-secreting cells displayed an NK T cell phenotype. The predominance of IFN-\u03b3 vs IL-4, however, is determined by the type of mCD1+ APC, suggesting the potential for APC regulation of cytokine production by NK T cells. Among a panel of 10 mCD1-autoreactive T cell hybridomas, only the ones that express the typical V\u03b114J\u03b1281 TCR rearrangement of NK T cells responded to \u03b1-GalCer. Fixation or treatment of mCD1+ APCs with an inhibitor of endosomal acidification and the use of mCD1 mutants unable to traffic through endosome still allowed \u03b1-GalCer to stimulate NK T cells. Thus, endosomal trafficking and Ag processing are not required for glycolipid recognition. In summary, \u03b1-GalCer might be the autologous ligand, or a mimic of a glycolipid ligand, involved in the mCD1-mediated stimulation of NK T cells.</jats:p>",
  "DOI": "10.4049/jimmunol.161.7.3271",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2022,
        12,
        30
      ]
    ],
    "date-time": "2022-12-30T21:15:18Z",
    "timestamp": 1672434918000
  },
  "page": "3271-3281",
  "source": "Crossref",
  "is-referenced-by-count": 310,
  "title": "Selective Ability of Mouse CD1 to Present Glycolipids: \u03b1-Galactosylceramide Specifically Stimulates V\u03b114+ NK T Lymphocytes",
  "prefix": "10.1093",
  "volume": "161",
  "author": [
    {
      "given": "Nicolas",
      "family": "Burdin",
      "sequence": "first",
      "affiliation": [
        {
          "name": "*Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;"
        }
      ]
    },
    {
      "given": "Laurent",
      "family": "Brossay",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "*Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;"
        }
      ]
    },
    {
      "given": "Yasuhiko",
      "family": "Koezuka",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "\u2020Pharmaceutical Research laboratory, Kirin Brewery Co., Takasaki-shi, Gumna, Japan;"
        }
      ]
    },
    {
      "given": "Stephen T.",
      "family": "Smiley",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "\u2021Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, MA 02115;"
        }
      ]
    },
    {
      "given": "Michael J.",
      "family": "Grusby",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "\u2021Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, MA 02115;"
        }
      ]
    },
    {
      "given": "Ming",
      "family": "Gui",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "\u00a7Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111; and"
        }
      ]
    },
    {
      "given": "Masaru",
      "family": "Taniguchi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "\u00b6CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, Chuo, Chiba, Japan"
        }
      ]
    },
    {
      "given": "Kyoko",
      "family": "Hayakawa",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "\u00a7Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111; and"
        }
      ]
    },
    {
      "given": "Mitchell",
      "family": "Kronenberg",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "*Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;"
        }
      ]
    }
  ],
  "member": "286",
  "reference": [
    {
      "key": "2022123021122009600_R1",
      "doi-asserted-by": "crossref",
      "unstructured": "Porcelli, S. A.. 1995. The CD1 family: a third lineage of antigen-presenting molecules. Adv. Immunol.\u200859: 1",
      "DOI": "10.1016/S0065-2776(08)60629-X"
    },
    {
      "key": "2022123021122009600_R2",
      "unstructured": "Hughes, A. L.. 1991. Evolutionary origin and diversification of the mammalian CD1 antigen genes. Mol. Biol. Evol.\u20088: 185"
    },
    {
      "key": "2022123021122009600_R3",
      "doi-asserted-by": "crossref",
      "unstructured": "Sugita, M., R. M. Jackman, E. van Donselaar, S. M. Behar, R. A. Rogers, P. J. Peters, M. B. Brenner, S. A. Porcelli. 1996. Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs. Science\u2008273: 349",
      "DOI": "10.1126/science.273.5273.349"
    },
    {
      "key": "2022123021122009600_R4",
      "doi-asserted-by": "crossref",
      "unstructured": "Brossay, L., S. Tangri, M. Bix, S. Cardell, R. Locksley, M. Kronenberg. 1998. Mouse CD1 autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J. Immunol.\u2008160: 3681",
      "DOI": "10.4049/jimmunol.160.8.3681"
    },
    {
      "key": "2022123021122009600_R5",
      "doi-asserted-by": "crossref",
      "unstructured": "Brutkiewicz, R. R., J. R. Bennink, J. W. Yewdell, A. Bendelac. 1995. TAP-independent, \u03b22-microglobulin-dependent surface expression of functional mouse CD1.1. J. Exp. Med.\u2008182: 1913",
      "DOI": "10.1084/jem.182.6.1913"
    },
    {
      "key": "2022123021122009600_R6",
      "doi-asserted-by": "crossref",
      "unstructured": "Teitell, M., H. R. Holcombe, L. Brossay, A. Hagenbaugh, M. J. Jackson, L. Pond, S. P. Balk, C. Terhorst, P. A. Peterson, M. Kronenberg. 1997. Nonclassical behavior of the mouse CD1 molecule. J. Immunol.\u2008158: 2143",
      "DOI": "10.4049/jimmunol.158.5.2143"
    },
    {
      "key": "2022123021122009600_R7",
      "doi-asserted-by": "crossref",
      "unstructured": "Brossay, L., D. Jullien, S. Cardell, B. C. Sydora, N. Burdin, R. L. Modlin, M. Kronenberg. 1997. mCD1 is mainly expressed on hemopoietic derived cells. J. Immunol.\u2008159: 1216",
      "DOI": "10.4049/jimmunol.159.3.1216"
    },
    {
      "key": "2022123021122009600_R8",
      "doi-asserted-by": "crossref",
      "unstructured": "Zeng, Z. H., A. R. Castan\u0303o, B. Segelke, E. A. Stura, P. A. Peterson, I. A. Wilson. 1997. The crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science\u2008277: 339",
      "DOI": "10.1126/science.277.5324.339"
    },
    {
      "key": "2022123021122009600_R9",
      "doi-asserted-by": "crossref",
      "unstructured": "Maher, J. K., M. Kronenberg. 1997. The role of CD1 molecules in immune responses to infection. Curr. Opin. Immunol.\u20089: 456",
      "DOI": "10.1016/S0952-7915(97)80095-7"
    },
    {
      "key": "2022123021122009600_R10",
      "doi-asserted-by": "crossref",
      "unstructured": "Bendelac, A., M. N. Rivera, S. H. Park, J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity and function. Annu. Rev. Immunol.\u200815: 535",
      "DOI": "10.1146/annurev.immunol.15.1.535"
    },
    {
      "key": "2022123021122009600_R11",
      "doi-asserted-by": "crossref",
      "unstructured": "Castan\u0303o, A. R., S. Tangri, J. E. Miller, H. R. Holcombe, M. R. Jackson, W. D. Huse, M. Kronenberg, P. A. Peterson. 1995. Peptide binding and presentation by mouse CD1. Science\u2008269: 223",
      "DOI": "10.1126/science.7542403"
    },
    {
      "key": "2022123021122009600_R12",
      "doi-asserted-by": "crossref",
      "unstructured": "Lee, D. J., A. Abeyratne, D. A. Carson, M. Corr. 1998. Induction of an antigen-specific CD1-restricted cytotoxic T lymphocyte response in vivo. J. Exp. Med.\u2008187: 433",
      "DOI": "10.1084/jem.187.3.433"
    },
    {
      "key": "2022123021122009600_R13",
      "doi-asserted-by": "crossref",
      "unstructured": "Makino, Y., R. Kanno, T. Ito, K. Higashino, M. Taniguchi. 1995. Predominant expression of invariant V\u03b114+ TCR \u03b1 chain in NK1.1+ T cell populations. Int. Immunol.\u20087: 1157",
      "DOI": "10.1093/intimm/7.7.1157"
    },
    {
      "key": "2022123021122009600_R14",
      "doi-asserted-by": "crossref",
      "unstructured": "Taniguchi, M., H. Koseki, T. Tokuhisa, K. Masuda, H. Sato, E. Kondo, T. Kawano, J. Cui, A. Perkes, S. Koyasu, Y. Makino. 1996. Essential requirement of an invariant V\u03b114 T cell antigen receptor expression in the development of natural killer T cells. Proc. Natl. Acad. Sci. USA\u200893: 11025",
      "DOI": "10.1073/pnas.93.20.11025"
    },
    {
      "key": "2022123021122009600_R15",
      "doi-asserted-by": "crossref",
      "unstructured": "Bendelac, A., R. D. Hunziker, O. Lantz. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med.\u2008184: 1285",
      "DOI": "10.1084/jem.184.4.1285"
    },
    {
      "key": "2022123021122009600_R16",
      "doi-asserted-by": "crossref",
      "unstructured": "Exley, M., J. Garcia, S. P. Balk, S. Porcelli. 1997. Requirements for CD1d recognition by human invariant V\u03b124+ CD4\u2212CD8\u2212 T cells. J. Exp. Med.\u2008186: 109",
      "DOI": "10.1084/jem.186.1.109"
    },
    {
      "key": "2022123021122009600_R17",
      "doi-asserted-by": "crossref",
      "unstructured": "Yoshimoto, T., W. E. Paul. 1994. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med.\u2008179: 1285",
      "DOI": "10.1084/jem.179.4.1285"
    },
    {
      "key": "2022123021122009600_R18",
      "doi-asserted-by": "crossref",
      "unstructured": "Yoshimoto, T., A. Bendelac, J. Hu-Li, W. E. Paul. 1995. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. USA\u200892: 11931",
      "DOI": "10.1073/pnas.92.25.11931"
    },
    {
      "key": "2022123021122009600_R19",
      "doi-asserted-by": "crossref",
      "unstructured": "Yoshimoto, T., A. Bendelac, C. Watson, J. Hu-Li, W. E. Paul. 1995. Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science\u2008270: 1845",
      "DOI": "10.1126/science.270.5243.1845"
    },
    {
      "key": "2022123021122009600_R20",
      "doi-asserted-by": "crossref",
      "unstructured": "Smiley, S. T., M. H. Kaplan, M. J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science\u2008275: 977",
      "DOI": "10.1126/science.275.5302.977"
    },
    {
      "key": "2022123021122009600_R21",
      "doi-asserted-by": "crossref",
      "unstructured": "Mendiratta, S. J., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, L. Van Kaer. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity\u20086: 469",
      "DOI": "10.1016/S1074-7613(00)80290-3"
    },
    {
      "key": "2022123021122009600_R22",
      "doi-asserted-by": "crossref",
      "unstructured": "Chen, Y. H., N. M. Chiu, M. Mandal, N. Wang, C. R. Wang. 1997. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity\u20086: 459",
      "DOI": "10.1016/S1074-7613(00)80289-7"
    },
    {
      "key": "2022123021122009600_R23",
      "doi-asserted-by": "crossref",
      "unstructured": "Cui, J., T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, M. Taniguchi. 1997. Requirement for V\u03b114 NKT cells in IL-12-mediated rejection of tumors. Science\u2008278: 1623",
      "DOI": "10.1126/science.278.5343.1623"
    },
    {
      "key": "2022123021122009600_R24",
      "doi-asserted-by": "crossref",
      "unstructured": "Takeda, K., S. Seki, K. Ogasawara, R. Anzai, W. Hashimoto, K. Sugiura, M. Takahashi, M. Satoh, K. Kumagai. 1996. Liver NK1.1+ CD4+ \u03b1\u03b2 T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis. J. Immunol.\u2008156: 3366",
      "DOI": "10.4049/jimmunol.156.9.3366"
    },
    {
      "key": "2022123021122009600_R25",
      "doi-asserted-by": "crossref",
      "unstructured": "Sugie, T., H. Kubota, M. Sato, E. Nakamura, M. Imamura, N. Minato. 1996. NK 1+ CD4\u2212CD8\u2212 \u03b1\u03b2 T cells in the peritoneal cavity: specific T cell receptor-mediated cytotoxicity and selective IFN\u03b3 production against B cell leukemia and myeloma cells. J. Immunol.\u2008157: 3925",
      "DOI": "10.4049/jimmunol.157.9.3925"
    },
    {
      "key": "2022123021122009600_R26",
      "doi-asserted-by": "crossref",
      "unstructured": "Tamada, K., M. Harada, K. Abe, T. Li, H. Tada, Y. Onoe, K. Nomoto. 1997. Immunosuppressive activity of cloned natural killer (NK1.1+) T cells established from murine tumor-infiltrating lymphocytes. J. Immunol.\u2008158: 4846",
      "DOI": "10.4049/jimmunol.158.10.4846"
    },
    {
      "key": "2022123021122009600_R27",
      "doi-asserted-by": "crossref",
      "unstructured": "Wilson, S. B., S. C. Kent, K. T. Patton, T. Orban, R. A. Jackson, M. Exley, S. Porcelli, D. A. Schatz, M. A. Atkinson, S. P. Balk, J. L. Strominger, D. A. Hafler. 1998. Extreme Th1 bias of invariant V\u03b124J\u03b1Q T cells in type 1 diabetes. Nature\u2008391: 177",
      "DOI": "10.1038/34419"
    },
    {
      "key": "2022123021122009600_R28",
      "doi-asserted-by": "crossref",
      "unstructured": "Zeng, D., M. Dick, L. Cheng, M. Amano, S. Dejbakhsh-Jones, P. Huie, R. Sibley, S. Strober. 1998. Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines. J. Exp. Med.\u2008187: 525",
      "DOI": "10.1084/jem.187.4.525"
    },
    {
      "key": "2022123021122009600_R29",
      "doi-asserted-by": "crossref",
      "unstructured": "Sumida, T., A. Sakamoto, H. Murata, Y. Makino, H. Takahashi, S. Yoshida, K. Nishioka, I. Iwamoto, M. Taniguchi. 1995. Selective reduction of T cell. bearing invariant V\u03b124J\u03b1Q antigen receptor in patients with systemic sclerosis. J. Exp. Med.\u2008182: 1163",
      "DOI": "10.1084/jem.182.4.1163"
    },
    {
      "key": "2022123021122009600_R30",
      "doi-asserted-by": "crossref",
      "unstructured": "Mieza, M. A., T. Itoh, J. Q. Cui, Y. Makino, T. Kawano, K. Tsuchida, T. Koike, T. Shirai, H. Yagita, A. Matsuzawa, H. Koseki, M. Taniguchi. 1996. Selective reduction of V\u03b114+ NK T cells associated with disease development in autoimmune-prone mice. J. Immunol.\u2008156: 4035",
      "DOI": "10.4049/jimmunol.156.10.4035"
    },
    {
      "key": "2022123021122009600_R31",
      "doi-asserted-by": "crossref",
      "unstructured": "Teixeira, H. C., S. H. Kaufmann. 1994. Role of NK1.1+ cells in experimental listeriosis: NK1+ cells are early IFN\u03b3 producers but impair resistance to Listeria monocytogenes infection. J. Immunol.\u2008152: 1873",
      "DOI": "10.4049/jimmunol.152.4.1873"
    },
    {
      "key": "2022123021122009600_R32",
      "doi-asserted-by": "crossref",
      "unstructured": "Emoto, M., Y. Emoto, S. H. Kaufmann. 1995. Interleukin-4-producing CD4+ NK1.1+ TCR \u03b1\u03b2 intermediate liver lymphocytes are down-regulated by Listeria monocytogenes. Eur. J. Immunol.\u200825: 3321",
      "DOI": "10.1002/eji.1830251218"
    },
    {
      "key": "2022123021122009600_R33",
      "doi-asserted-by": "crossref",
      "unstructured": "Denkers, E. Y., T. Scharton-Kersten, S. Barbieri, P. Caspar, A. Sher. 1996. A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection. J. Exp. Med.\u2008184: 131",
      "DOI": "10.1084/jem.184.1.131"
    },
    {
      "key": "2022123021122009600_R34",
      "doi-asserted-by": "crossref",
      "unstructured": "Enomoto, A., H. Nishimura, Y. Yoshikai. 1997. Predominant appearance of NK1.1+ T cells producing IL-4 may be involved in the increased susceptibility of mice with the beige mutation during Salmonella infection. J. Immunol.\u2008158: 2268",
      "DOI": "10.4049/jimmunol.158.5.2268"
    },
    {
      "key": "2022123021122009600_R35",
      "doi-asserted-by": "crossref",
      "unstructured": "Moody, D. B., B. B. Reinhold, M. R. Guy, E. M. Beckman, D. E. Frederique, S. T. Furlong, S. Ye, V. N. Reinhold, P. A. Sieling, R. L. Modlin, G. S. Besra, S. A. Porcelli. 1997. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science\u2008278: 283",
      "DOI": "10.1126/science.278.5336.283"
    },
    {
      "key": "2022123021122009600_R36",
      "doi-asserted-by": "crossref",
      "unstructured": "Beckman, E. M., S. A. Porcelli, C. T. Morita, S. M. Behar, S. T. Furlong, M. B. Brenner. 1994. Recognition of a lipid antigen by CD1-restricted \u03b1\u03b2+ T cells. Nature\u2008372: 691",
      "DOI": "10.1038/372691a0"
    },
    {
      "key": "2022123021122009600_R37",
      "doi-asserted-by": "crossref",
      "unstructured": "Porcelli, S., C. T. Morita, M. B. Brenner. 1992. CD1b restricts the response of human CD4\u22128\u2212 T lymphocytes to a microbial antigen. Nature\u2008360: 593",
      "DOI": "10.1038/360593a0"
    },
    {
      "key": "2022123021122009600_R38",
      "doi-asserted-by": "crossref",
      "unstructured": "Sieling, P. A., D. Chatterjee, S. A. Porcelli, T. I. Prigozy, R. J. Mazzaccaro, T. Soriano, B. R. Bloom, M. B. Brenner, M. Kronenberg, P. J. Brennan, R. L. Modlin. 1995. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science\u2008269: 227",
      "DOI": "10.1126/science.7542404"
    },
    {
      "key": "2022123021122009600_R39",
      "doi-asserted-by": "crossref",
      "unstructured": "Cardell, S., S. Tangri, S. Chan, M. Kronenberg, C. Benoist, D. Mathis. 1995. CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med.\u2008182: 993",
      "DOI": "10.1084/jem.182.4.993"
    },
    {
      "key": "2022123021122009600_R40",
      "doi-asserted-by": "crossref",
      "unstructured": "Bendelac, A., O. Lantz, M. E. Quimby, J. W. Yewdell, J. R. Bennink, R. R. Brutkiewicz. 1995. CD1 recognition by mouse NK1+ T lymphocytes. Science\u2008268: 863",
      "DOI": "10.1126/science.7538697"
    },
    {
      "key": "2022123021122009600_R41",
      "doi-asserted-by": "crossref",
      "unstructured": "Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, H. Koseki, M. Taniguchi. 1997. CD1d-restricted and TCR-mediated activation of V\u03b114 NK T cells by glycosylceramides. Science\u2008278: 1626",
      "DOI": "10.1126/science.278.5343.1626"
    },
    {
      "key": "2022123021122009600_R42",
      "doi-asserted-by": "crossref",
      "unstructured": "Morita, M., T. Natori, K. Akimoto, T. Osawa, H. Fukushima, Y. Koezuka. 1995. Syntheses of \u03b1-, \u03b2-monoglycosylceramides and four diastereomers of an \u03b1-galactosylceramide. Bioorg Med. Chem. Lett.\u20085: 699",
      "DOI": "10.1016/0960-894X(95)00097-D"
    },
    {
      "key": "2022123021122009600_R43",
      "doi-asserted-by": "crossref",
      "unstructured": "Watanabe, Y., T. Yamamoto, T. Okazaki. 1996. Synthesis of 2,6-Di-O-\u03b1-D mannopyranosylphosphatidyl-D-myo-inositol: utilization of glycosylation and phosphorylation based on phosphite chemistry. Tetrahedron\u200853: 903",
      "DOI": "10.1016/S0040-4020(96)01038-1"
    },
    {
      "key": "2022123021122009600_R44",
      "doi-asserted-by": "crossref",
      "unstructured": "Khoo, K. H., A. Dell, H. R. Morris, P. J. Brennan, D. Chatterjee. 1995. Structural definition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: definition of a common anchor for lipomannan and lipoarabinomannan. Glycobiology\u20085: 117",
      "DOI": "10.1093/glycob/5.1.117"
    },
    {
      "key": "2022123021122009600_R45",
      "doi-asserted-by": "crossref",
      "unstructured": "Ernst, W. A., J. Maher, S. Cho, K. R. Niazi, D. Chatterjee, B. D. Moody, G. S. Besra, Y. Watanabe, P. E. Jensen, S. A. Porcelli, M. Kronenberg, R. L. Modlin. 1998. Molecular interaction of CD1b with lipoglycan antigens. Immunity\u20088: 331",
      "DOI": "10.1016/S1074-7613(00)80538-5"
    },
    {
      "key": "2022123021122009600_R46",
      "unstructured": "Yamaguchi, Y., K. Motoki, H. Ueno, K. Maeda, E. Kobayashi, H. Inoue, H. Fukushima, Y. Koezuka. 1996. Enhancing effects of (2S, 3S, 4R)-1-O-(\u03b1-D-galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and antimetastatic activity of KRN7000-pretreated antigen-presenting cells. Oncol. Res.\u20088: 399"
    },
    {
      "key": "2022123021122009600_R47",
      "unstructured": "Kobayashi, E., K. Motoki, T. Uchida, H. Fukushima, Y. Koezuka. 1995. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol. Res.\u20087: 529"
    },
    {
      "key": "2022123021122009600_R48",
      "doi-asserted-by": "crossref",
      "unstructured": "Morita, M., K. Motoki, K. Akimoto, T. Natori, T. Sakai, E. Sawa, K. Yamaji, Y. Koezuka, E. Kobayashi, H. Fukushima. 1995. Structure-activity relationship of \u03b1-galactosylceramides against B16-bearing mice. J. Med. Chem.\u200838: 2176",
      "DOI": "10.1021/jm00012a018"
    },
    {
      "key": "2022123021122009600_R49",
      "doi-asserted-by": "crossref",
      "unstructured": "Chen, H., W. E. Paul. 1997. Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN\u03b3 upon activation by anti-CD3 or CD1. J. Immunol.\u2008159: 2240",
      "DOI": "10.4049/jimmunol.159.5.2240"
    },
    {
      "key": "2022123021122009600_R50",
      "doi-asserted-by": "crossref",
      "unstructured": "Chen, H., H. Huang, W. E. Paul. 1997. NK1.1+ CD4+ T cells lose NK1.1 expression upon in vitro activation. J. Immunol.\u2008158: 5112",
      "DOI": "10.4049/jimmunol.158.11.5112"
    },
    {
      "key": "2022123021122009600_R51",
      "doi-asserted-by": "crossref",
      "unstructured": "Prigozy, T. I., P. A. Sieling, D. Clemens, P. L. Stewart, S. M. Behar, S. A. Porcelli, M. B. Brenner, R. L. Modlin, M. Kronenberg. 1997. The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity\u20086: 187",
      "DOI": "10.1016/S1074-7613(00)80425-2"
    },
    {
      "key": "2022123021122009600_R52",
      "doi-asserted-by": "crossref",
      "unstructured": "Porcelli, S. A., C. T. Morita, R. L. Modlin. 1996. T-cell recognition of non-peptide antigens. Curr. Opin. Immunol.\u20088: 510",
      "DOI": "10.1016/S0952-7915(96)80039-2"
    },
    {
      "key": "2022123021122009600_R53",
      "doi-asserted-by": "crossref",
      "unstructured": "Joyce, S., A. S. Woods, J. W. Yewdell, J. R. Bennink, A. D. De Silva, A. Boesteanu, S. P. Balk, R. J. Cotter, R. R. Brutkiewicz. 1998. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science\u2008279: 1541",
      "DOI": "10.1126/science.279.5356.1541"
    },
    {
      "key": "2022123021122009600_R54",
      "doi-asserted-by": "crossref",
      "unstructured": "Jullien, D., L. Brossay, P. A. Sieling, R. L. Modlin, M. Kronenberg. 1996. CD1: clues on a new antigen presenting pathway. Res. Immunol.\u2008147: 321",
      "DOI": "10.1016/0923-2494(96)89645-3"
    },
    {
      "key": "2022123021122009600_R55",
      "doi-asserted-by": "crossref",
      "unstructured": "Arase, H., N. Arase, T. Saito. 1996. IFN\u03b3 production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. J. Exp. Med.\u2008183: 2391",
      "DOI": "10.1084/jem.183.5.2391"
    },
    {
      "key": "2022123021122009600_R56",
      "doi-asserted-by": "crossref",
      "unstructured": "Vicari, A. P., A. Zlotnik. 1996. Mouse NK1.1+ T cells: a new family of T cells. Immunol. Today\u200817: 71",
      "DOI": "10.1016/0167-5699(96)80582-2"
    },
    {
      "key": "2022123021122009600_R57",
      "doi-asserted-by": "crossref",
      "unstructured": "Natori, T., Y. Koezuka, T. Higa. 1993. Agelasphins, novel \u03b1-galactosylceramides from the marine sponge Agelas Mauritanius. Tetrahedron Lett.\u200834: 5591",
      "DOI": "10.1016/S0040-4039(00)73889-5"
    },
    {
      "key": "2022123021122009600_R58",
      "doi-asserted-by": "crossref",
      "unstructured": "Nishimura, K., Y. Hirabayashi, A. Hamaoka, M. Matsumoto, A. Nakamura, K. Miseki. 1984. Molecular species of monoglycosylceramides in embryonic and adult Japanese quail intestine. Biochim. Biophys. Acta\u2008796: 269",
      "DOI": "10.1016/0005-2760(84)90127-9"
    },
    {
      "key": "2022123021122009600_R59",
      "doi-asserted-by": "crossref",
      "unstructured": "Dahiya, R., M. D. Brown, T. A. Brasitus. 1986. Distribution of glycosphingolipids of monkey small and large intestinal mucosa. Lipids\u200821: 107",
      "DOI": "10.1007/BF02534429"
    },
    {
      "key": "2022123021122009600_R60",
      "doi-asserted-by": "crossref",
      "unstructured": "Watanabe, K., T. Matsubara, S. Hakomori. 1976. \u03b1-L-Fucopyranosylceramide, a novel glycolipid accumulated in some of the human colon tumors. J. Biol. Chem.\u2008251: 2385",
      "DOI": "10.1016/S0021-9258(17)33598-6"
    },
    {
      "key": "2022123021122009600_R61",
      "doi-asserted-by": "crossref",
      "unstructured": "Lavie, Y., H. Cao, S. L. Bursten, A. E. Giuliano, M. C. Cabot. 1996. Accumulation of glucosylceramides in multidrug-resistant cancer cells. J. Biol. Chem.\u2008271: 19530",
      "DOI": "10.1074/jbc.271.32.19530"
    },
    {
      "key": "2022123021122009600_R62",
      "doi-asserted-by": "crossref",
      "unstructured": "Nakamura, E., H. Kubota, M. Sato, T. Sugie, O. Yoshida, N. Minato. 1997. Involvement of NK1+ CD4\u2212 CD8\u2212 \u03b1\u03b2 T cells and endogenous IL-4 in non-MHC-restricted rejection of embryonal carcinoma in genetically resistant mice. J. Immunol.\u2008158: 5338",
      "DOI": "10.4049/jimmunol.158.11.5338"
    },
    {
      "key": "2022123021122009600_R63",
      "doi-asserted-by": "crossref",
      "unstructured": "Kobayashi, E., K. Motoki, Y. Yamaguchi, T. Uchida, H. Fukushima, Y. Koezuka. 1996. Enhancing effects of \u03b1-, \u03b2-monoglycosylceramides on natural killer cell activity. Bioorg. Med. Chem.\u20084: 615",
      "DOI": "10.1016/0968-0896(96)00049-1"
    },
    {
      "key": "2022123021122009600_R64",
      "doi-asserted-by": "crossref",
      "unstructured": "Taniguchi, M., Y. Makino, J. Cui, K. Masuda, T. Kawano, H. Sato, E. Kondo, H. Koseki. 1996. V\u03b114+ NK T cells: a novel lymphoid cell lineage with regulatory function. J. Allergy Clin. Immunol.\u200898: S263",
      "DOI": "10.1016/S0091-6749(96)70074-X"
    },
    {
      "key": "2022123021122009600_R65",
      "doi-asserted-by": "crossref",
      "unstructured": "Davodeau, F., M. A. Peyrat, A. Necker, R. Dominici, F. Blanchard, C. Leget, J. Gaschet, P. Costa, Y. Jacques, A. Godard, H. Vie, A. Poggi, F. Romagne, M. Bonneville. 1997. Close phenotypic and functional similarities between human and murine \u03b1\u03b2 T cells expressing invariant TCR \u03b1-chains. J. Immunol.\u2008158: 5603",
      "DOI": "10.4049/jimmunol.158.12.5603"
    }
  ],
  "container-title": "The Journal of Immunology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.aai.org/jimmunol/article-pdf/161/7/3271/1089919/im199803271o.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://journals.aai.org/jimmunol/article-pdf/161/7/3271/1089919/im199803271o.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        1,
        2
      ]
    ],
    "date-time": "2025-01-02T17:32:19Z",
    "timestamp": 1735839139000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.aai.org/jimmunol/article/161/7/3271/7161/Selective-Ability-of-Mouse-CD1-to-Present"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        10,
        1
      ]
    ]
  },
  "references-count": 65,
  "journal-issue": {
    "issue": "7",
    "published-print": {
      "date-parts": [
        [
          1998,
          10,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.4049/jimmunol.161.7.3271",
  "relation": {},
  "ISSN": [
    "0022-1767",
    "1550-6606"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1998,
        10,
        1
      ]
    ]
  }
}