DOI: 10.4049/jimmunol.161.10.5138. Cutting Edge: LFA-1 Interaction with ICAM-1 and ICAM-2 Regulates Th2 Cytokine Production

Cutting Edge: LFA-1 Interaction with ICAM-1 and ICAM-2 Regulates Th2 Cytokine Production

10.4049/jimmunol.161.10.5138

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The role of CD28/B7 and LFA-1/ICAM costimulation in proliferation and Th1/Th2 differentiation of naive CD4+ T cells was addressed using T cells from DO11.10 TCR transgenic mice stimulated by dendritic cells. The blockade of either CD28/B7 or LFA-1/ICAM interactions partially inhibited T cell proliferation. By comparison, blocking CD28/B7 costimulation inhibited IL-4 and IL-5 (Th2 cytokine) production, whereas blocking LFA-1/ICAM-1 or LFA-1/ICAM-2 led to a significant increase (15- to 40-fold) of Th2 cytokines. The combination of anti-ICAM-1 and anti-ICAM-2 mAbs had a synergistic effect with a 100- to 1000-fold increase of Th2 cytokine production. Thus, these two costimulatory pathways have opposing roles in the regulation of Th2 development.

Bibliography

Salomon, B., & Bluestone, J. A. (1998). Cutting Edge: LFA-1 Interaction with ICAM-1 and ICAM-2 Regulates Th2 Cytokine Production. The Journal of Immunology, 161(10), 5138â5142.

Authors 2

Benoı̂t Salomon (first)
Jeffrey A Bluestone (additional)

References 33 Referenced 161

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Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 8:57 a.m.)
Deposited	5 months ago (March 31, 2025, 11:20 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 7, 2025, 5:47 p.m.)
Issued	26 years, 10 months ago (Nov. 1, 1998)
Published	26 years, 10 months ago (Nov. 1, 1998)
Published Online	26 years, 9 months ago (Nov. 15, 1998)
Published Print	26 years, 9 months ago (Nov. 15, 1998)

Funders 0

None

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