Crossref
journal-article
Oxford University Press (OUP)
The Journal of Immunology (286)
Abstract
Abstract TCR down-regulation plays an important role in modulating T cell responses both during T cell development and in mature T cells. Down-regulation of the TCR is induced by engagement of the TCR by specific ligands and/or by activation of protein kinase C (PKC). We report here that ligand- and PKC-induced TCR down-regulation is mediated by two distinct, independent mechanisms. Ligand-induced TCR down-regulation is dependent on the protein tyrosine kinases p56lck and p59fyn but independent of PKC and the CD3γ leucine-based (L-based) internalization motif. In contrast, PKC-induced TCR down-regulation is dependent on the CD3γ L-based internalization motif but independent of p56lck and p59fyn. Finally, our data indicate that in the absence of TCR ligation, TCR expression levels can be finely regulated via the CD3γ L-based motif by the balance between PKC and serine/threonine protein phosphatase activities. Such a TCR ligation-independent regulation of TCR expression levels could probably be important in determining the activation threshold of T cells in their encounter with APC.
References
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Dates
| Type | When |
|---|---|
| Created | 2 years, 8 months ago (Dec. 31, 2022, 7:14 p.m.) |
| Deposited | 5 months ago (March 31, 2025, 9:58 a.m.) |
| Indexed | 1 month, 1 week ago (July 26, 2025, 5:13 a.m.) |
| Issued | 27 years, 2 months ago (July 1, 1998) |
| Published | 27 years, 2 months ago (July 1, 1998) |
| Published Online | 27 years, 2 months ago (July 1, 1998) |
| Published Print | 27 years, 2 months ago (July 1, 1998) |
@article{Lauritsen_1998, title={Two Distinct Pathways Exist for Down-Regulation of the TCR}, volume={161}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.161.1.260}, DOI={10.4049/jimmunol.161.1.260}, number={1}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Lauritsen, Jens Peter H and Christensen, Mette D and Dietrich, Jes and Kastrup, Jesper and Ødum, Niels and Geisler, Carsten}, year={1998}, month=jul, pages={260–267} }