DOI: 10.4049/jimmunol.160.6.2555. Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

10.4049/jimmunol.160.6.2555

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Asthma has been increasing in industrialized countries. Evidence suggests that asthma is caused by a Th2 immune response to inhaled environmental Ags and that childhood infections protect against this. We have shown that bacterial DNA contains motifs, centered on unmethylated CpG dinucleotides, which induce Th1-type responses. We hypothesized that the Th1 effect of these CpG motifs may oppose the Th2 type allergic response and suggest that this may account for the protective effect of childhood infection against asthma. We examined the effects of CpG-motif oligodeoxynucleotides (CpG ODN) in a murine model of asthma. Airway eosinophilia, Th2 cytokine induction, IgE production, and bronchial hyperreactivity were prevented by coadministration of CpG ODN with the Ag. Significantly, in a previously sensitized mouse, CpG ODN can prevent allergen-induced airway inflammation. These studies suggest that exposure to CpG DNA may protect against asthma.

Bibliography

Kline, J. N., Waldschmidt, T. J., Businga, T. R., Lemish, J. E., Weinstock, J. V., Thorne, P. S., & Krieg, A. M. (1998). Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma. The Journal of Immunology, 160(6), 2555â2559.

Authors 7

Joel N. Kline (first)
Thomas J. Waldschmidt (additional)
Thomas R. Businga (additional)
Jennifer E. Lemish (additional)
Joel V. Weinstock (additional)
Peter S. Thorne (additional)
Arthur M. Krieg (additional)

References 20 Referenced 436

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 9:15 a.m.)
Deposited	8 months ago (Jan. 2, 2025, 12:50 p.m.)
Indexed	3 days, 19 hours ago (Sept. 3, 2025, 6:14 a.m.)
Issued	27 years, 5 months ago (March 15, 1998)
Published	27 years, 5 months ago (March 15, 1998)
Published Print	27 years, 5 months ago (March 15, 1998)

Funders 0

None

BibTeX

@article{Kline_1998, title={Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma}, volume={160}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.160.6.2555}, DOI={10.4049/jimmunol.160.6.2555}, number={6}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Kline, Joel N. and Waldschmidt, Thomas J. and Businga, Thomas R. and Lemish, Jennifer E. and Weinstock, Joel V. and Thorne, Peter S. and Krieg, Arthur M.}, year={1998}, month=mar, pages={2555–2559} }

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