DOI: 10.4049/jimmunol.160.3.1212. CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

10.4049/jimmunol.160.3.1212

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

AbstractThymectomy of susceptible strains of mice on day 3 of life results in a spectrum of organ-specific autoimmunity that can be prevented by reconstitution of the thymectomized animals early in life with normal adult lymphocytes. The effectors and suppressors of autoimmunity in this model have been convincingly shown to be CD4+ T cells. It has been demonstrated recently that the regulatory CD4+ T cells that prevent disease coexpress CD25. We have further characterized the population of CD4+CD25+ immunoregulatory cells and demonstrated that they can suppress not only the induction of disease post-thymectomy, but can also efficiently suppress disease induced by cloned autoantigen-specific effector cells. Furthermore, the CD4+CD25+ T cells appear to be members of a unique lineage of regulatory T cells, as the induction of CD25 expression on a monospecific population of T cells derived from TCR transgenic SCID mice did not result in suppression of post-thymectomy autoimmunity. In addition, the TCR transgenic SCID mice were highly susceptible to autoimmune disease induced by the cloned line of autoantigen-specific effectors, while normal mice were relatively resistant. The capacity of the cloned line to transfer disease to nu/nu recipients could be inhibited by normal spleen cell populations containing CD4+CD25+ cells and by purified CD4+CD25+ cells. Although the target Ag(s) and mechanism of action of the CD4+CD25+ T cells remain to be determined, it is likely that they also play an important role in modulating other autoimmune diseases that are mediated by activation of “ignorant” self-reactive T cells present in the normal peripheral lymphocyte pool.

Bibliography

Suri-Payer, E., Amar, A. Z., Thornton, A. M., & Shevach, E. M. (1998). CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells. The Journal of Immunology, 160(3), 1212â1218.

Authors 4

Elisabeth Suri-Payer (first)
Anna Z. Amar (additional)
Angela M. Thornton (additional)
Ethan M. Shevach (additional)

References 40 Referenced 653

Dates

Type	When
Created	2 years, 7 months ago (Dec. 31, 2022, 9:11 a.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 1:36 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 7, 2025, 5:17 a.m.)
Issued	27 years, 6 months ago (Feb. 1, 1998)
Published	27 years, 6 months ago (Feb. 1, 1998)
Published Print	27 years, 6 months ago (Feb. 1, 1998)

Funders 0

None

BibTeX

@article{Suri_Payer_1998, title={CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells}, volume={160}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.160.3.1212}, DOI={10.4049/jimmunol.160.3.1212}, number={3}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Suri-Payer, Elisabeth and Amar, Anna Z. and Thornton, Angela M. and Shevach, Ethan M.}, year={1998}, month=feb, pages={1212–1218} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>Thymectomy of susceptible strains of mice on day 3 of life results in a spectrum of organ-specific autoimmunity that can be prevented by reconstitution of the thymectomized animals early in life with normal adult lymphocytes. The effectors and suppressors of autoimmunity in this model have been convincingly shown to be CD4+ T cells. It has been demonstrated recently that the regulatory CD4+ T cells that prevent disease coexpress CD25. We have further characterized the population of CD4+CD25+ immunoregulatory cells and demonstrated that they can suppress not only the induction of disease post-thymectomy, but can also efficiently suppress disease induced by cloned autoantigen-specific effector cells. Furthermore, the CD4+CD25+ T cells appear to be members of a unique lineage of regulatory T cells, as the induction of CD25 expression on a monospecific population of T cells derived from TCR transgenic SCID mice did not result in suppression of post-thymectomy autoimmunity. In addition, the TCR transgenic SCID mice were highly susceptible to autoimmune disease induced by the cloned line of autoantigen-specific effectors, while normal mice were relatively resistant. The capacity of the cloned line to transfer disease to nu/nu recipients could be inhibited by normal spleen cell populations containing CD4+CD25+ cells and by purified CD4+CD25+ cells. Although the target Ag(s) and mechanism of action of the CD4+CD25+ T cells remain to be determined, it is likely that they also play an important role in modulating other autoimmune diseases that are mediated by activation of \u201cignorant\u201d self-reactive T cells present in the normal peripheral lymphocyte pool.</jats:p>",
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    "0022-1767",
    "1550-6606"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1998,
        2,
        1
      ]
    ]
  }
}