DOI: 10.4049/jimmunol.159.3.1418. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

10.4049/jimmunol.159.3.1418

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Con A-induced hepatitis (Con A-hepatitis) is a hepatitis model in which hepatic injury is supposed to be caused by cytokines from activated T cells. To elucidate the pathogenesis of this disease, we analyzed the roles of IFN-gamma and TNF-alpha using deficient mice of these cytokines. Development of hepatitis was reduced significantly in IFN-gamma(-/-) mice, while susceptibility of TNF-alpha(-/-) mice was not changed. Interestingly, apoptotic cell death was observed in the affected livers of control or TNF-alpha(-/-) mice, but not in those of IFN-gamma(-/-) mice. Fas mRNA expression was increased in the livers of hepatitis mice, but less abundantly in those of IFN-gamma(-/-) mice. Since apoptosis of liver cells was rarely observed in Con A-treated lpr/lpr mice, involvement of the Fas-Fas ligand system in this apoptotic process was suggested. These observations suggest that IFN-gamma plays a central role in Con A-hepatitis by activating Fas-induced apoptosis of liver cells.

Bibliography

Tagawa, Y., Sekikawa, K., & Iwakura, Y. (1997). Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. The Journal of Immunology, 159(3), 1418â1428.

Authors 3

Y Tagawa (first)
K Sekikawa (additional)
Y Iwakura (additional)

References 0 Referenced 325

None

Dates

Type	When
Created	2 years, 7 months ago (Dec. 31, 2022, 9 a.m.)
Deposited	7 months, 4 weeks ago (Jan. 2, 2025, 1:03 p.m.)
Indexed	1 day, 22 hours ago (Aug. 29, 2025, 6:08 a.m.)
Issued	28 years ago (Aug. 1, 1997)
Published	28 years ago (Aug. 1, 1997)
Published Print	28 years ago (Aug. 1, 1997)

Funders 0

None

BibTeX

@article{Tagawa_1997, title={Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.}, volume={159}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.159.3.1418}, DOI={10.4049/jimmunol.159.3.1418}, number={3}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Tagawa, Y and Sekikawa, K and Iwakura, Y}, year={1997}, month=aug, pages={1418–1428} }

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