DOI: 10.4049/jimmunol.156.1.13. Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

10.4049/jimmunol.156.1.13

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract FAS/Apo-1 (CD95) is an apoptosis-signaling cell surface receptor belonging to the TNF receptor family. Tumor cells resistant to Fas-mediated apoptosis have been described, but to date, the mechanisms responsible for this resistance are not well understood. We found that a series of apoptosis-resistant clones from human HUT78 lymphoma cells express a splicing variant coding for a truncated Fas molecule that lacks the intracellular death-signaling domain. The mutation responsible for the FasExo8Del expression was identified as a deletion-insertion in the intron 7/exon 8 region of the Fas gene. Moreover this mutation affects the phenotype in a dominant negative fashion, i.e., even in the presence of the normal receptor.

Bibliography

Cascino, I., Papoff, G., De Maria, R., Testi, R., & Ruberti, G. (1996). Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. The Journal of Immunology, 156(1), 13â17.

Authors 5

I Cascino (first)
G Papoff (additional)
R De Maria (additional)
R Testi (additional)
G Ruberti (additional)

References 0 Referenced 122

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 3:03 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 12:53 p.m.)
Indexed	3 months, 2 weeks ago (May 18, 2025, 12:04 p.m.)
Issued	29 years, 8 months ago (Jan. 1, 1996)
Published	29 years, 8 months ago (Jan. 1, 1996)
Published Print	29 years, 8 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Cascino_1996, title={Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.}, volume={156}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.156.1.13}, DOI={10.4049/jimmunol.156.1.13}, number={1}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Cascino, I and Papoff, G and De Maria, R and Testi, R and Ruberti, G}, year={1996}, month=jan, pages={13–17} }

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