DOI: 10.4049/jimmunol.153.8.3386. Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.

Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.

10.4049/jimmunol.153.8.3386

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract This study investigated whether or not the localization of persisting Ag influenced the localization of memory B and/or of Ab-forming cells (AFC). As a model Ag, we used vesicular stomatitis virus, which does not measurably replicate extraneuronally in adult mice after peripheral infection. Our results show that memory B cells and AFC are induced at the site where Ag is present; induced memory B cells then recirculate throughout the lymphoid system independently of Ag localization. In contrast, AFC are induced only at the sites of Ag persistence. These triggered Ab producing cells do not recirculate through the lymphoid tissue but migrate to the bone marrow.

Bibliography

Bachmann, M. F., KÃ¼ndig, T. M., Odermatt, B., Hengartner, H., & Zinkernagel, R. M. (1994). Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells. The Journal of Immunology, 153(8), 3386â3397.

Authors 5

M F Bachmann (first)
T M Kündig (additional)
B Odermatt (additional)
H Hengartner (additional)
R M Zinkernagel (additional)

References 0 Referenced 70

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 6:59 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 11:33 a.m.)
Indexed	5 months, 1 week ago (March 30, 2025, 9:51 p.m.)
Issued	30 years, 10 months ago (Oct. 15, 1994)
Published	30 years, 10 months ago (Oct. 15, 1994)
Published Print	30 years, 10 months ago (Oct. 15, 1994)

Funders 0

None

BibTeX

@article{Bachmann_1994, title={Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.}, volume={153}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.153.8.3386}, DOI={10.4049/jimmunol.153.8.3386}, number={8}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Bachmann, M F and Kündig, T M and Odermatt, B and Hengartner, H and Zinkernagel, R M}, year={1994}, month=oct, pages={3386–3397} }

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