DOI: 10.4049/jimmunol.151.2.621. Effect of bcl-2 on Fas antigen-mediated cell death.

Effect of bcl-2 on Fas antigen-mediated cell death.

10.4049/jimmunol.151.2.621

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Fas Ag is a cell surface protein that can mediate apoptosis and belongs to the TNF receptor family. The product of protooncogene bcl-2, a membrane-associated protein, has been shown to inhibit apoptosis in various hematopoietic cells including B cells and T cells. To examine the possible interaction of the Fas Ag and bcl-2, we coexpressed human Fas Ag and bcl-2 cDNA in murine IL-3-dependent FDC-P1 cell line and murine lymphoma WR19L. FDC-P1 transformants expressing bcl-2 showed a prolonged survival to IL-3 depletion. FDC-P1 transformants expressing the Fas Ag alone were killed by anti-Fas antibody in the presence of IL-3. Overexpression of bcl-2 in FDC-P1 resulted in a partial inhibition of Fas-induced cell death. WR19L transformants expressing bcl-2 were partially resistant to the cytolytic activities of the TNF-alpha and anti-Fas antibody treatment. These results suggest that the Fas Ag and TNF receptor may share the same signaling pathway, and that bcl-2 interferes with the apoptotic process mediated by the Fas Ag and TNF receptor.

Bibliography

Itoh, N., Tsujimoto, Y., & Nagata, S. (1993). Effect of bcl-2 on Fas antigen-mediated cell death. The Journal of Immunology, 151(2), 621â627.

Authors 3

N Itoh (first)
Y Tsujimoto (additional)
S Nagata (additional)

References 0 Referenced 311

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 9:12 p.m.)
Deposited	5 months, 1 week ago (March 29, 2025, 9:15 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 7, 2025, 4:52 p.m.)
Issued	32 years, 2 months ago (July 1, 1993)
Published	32 years, 2 months ago (July 1, 1993)
Published Online	32 years, 1 month ago (July 15, 1993)
Published Print	32 years, 1 month ago (July 15, 1993)

Funders 0

None

BibTeX

@article{Itoh_1993, title={Effect of bcl-2 on Fas antigen-mediated cell death.}, volume={151}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.151.2.621}, DOI={10.4049/jimmunol.151.2.621}, number={2}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Itoh, N and Tsujimoto, Y and Nagata, S}, year={1993}, month=jul, pages={621–627} }

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