DOI: 10.4049/jimmunol.148.7.2045. Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways.

Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways.

10.4049/jimmunol.148.7.2045

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract We here demonstrate that ligand binding to MHC class I molecules induces homotypic cell adhesion of lymphocytes and monocytes. mAb to beta 2-microglobulin caused sustained, largely LFA-1-independent adhesion whereas mAb to the MHC class I alpha H chain caused transient LFA-1-dependent adhesion. Both the protein kinase C inhibitor sphingosine and the tyrosine kinase inhibitor genistein abrogated MHC class I-mediated cellular adhesion. These results indicate that MHC class I molecules transduce signals that induce cell adhesion and suggest that interaction between MHC class I-restricted T cells and APC may result in reciprocal enhanced adhesiveness of these cells.

Bibliography

Spertini, F., Chatila, T., & Geha, R. S. (1992). Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways. The Journal of Immunology, 148(7), 2045â2049.

Authors 3

F Spertini (first)
T Chatila (additional)
R S Geha (additional)

References 0 Referenced 22

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 4:59 a.m.)
Deposited	7 months, 4 weeks ago (Jan. 2, 2025, 11:30 a.m.)
Indexed	2 months ago (June 27, 2025, 9:46 a.m.)
Issued	33 years, 5 months ago (April 1, 1992)
Published	33 years, 5 months ago (April 1, 1992)
Published Print	33 years, 5 months ago (April 1, 1992)

Funders 0

None

BibTeX

@article{Spertini_1992, title={Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways.}, volume={148}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.148.7.2045}, DOI={10.4049/jimmunol.148.7.2045}, number={7}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Spertini, F and Chatila, T and Geha, R S}, year={1992}, month=apr, pages={2045–2049} }

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