DOI: 10.4049/jimmunol.148.4.1274. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

10.4049/jimmunol.148.4.1274

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The cell surface Fas antigen is a membrane-associated polypeptide which can mediate apoptosis. cDNA clones encoding the Fas antigen were isolated from a cDNA library constructed with mRNA from the mouse macrophage cell line BAM3. The nucleotide sequence and the deduced amino acid sequence of the mouse Fas antigen were 58.5 and 49.3% identical, respectively, to the corresponding sequences of human Fas antigen cDNA. The mouse Fas antigen consists of 306 amino acids with a calculated Mr of 34,971 and contains a single transmembrane domain which divides the molecule into extracellular and cytoplasmic domains. A 2.1-kb mRNA coding for the Fas antigen was detected in the mouse thymus, heart, liver, and ovary but not in brain and spleen. The expression of the Fas antigen gene in mouse fibroblast L929 and macrophage BAM3 cell lines was significantly induced by treatment with IFN-gamma but not by IFN-alpha/beta. Interspecific backcross analysis indicated that the gene coding for the Fas antigen is in the distal region of mouse chromosome 19.

Bibliography

Watanabe-Fukunaga, R., Brannan, C. I., Itoh, N., Yonehara, S., Copeland, N. G., Jenkins, N. A., & Nagata, S. (1992). The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. The Journal of Immunology, 148(4), 1274â1279.

Authors 7

R Watanabe-Fukunaga (first)
C I Brannan (additional)
N Itoh (additional)
S Yonehara (additional)
N G Copeland (additional)
N A Jenkins (additional)
S Nagata (additional)

References 0 Referenced 598

None

Dates

Type	When
Created	2 years, 7 months ago (Dec. 31, 2022, 4:10 a.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 12:29 p.m.)
Indexed	2 weeks, 5 days ago (Aug. 7, 2025, 5:02 p.m.)
Issued	33 years, 6 months ago (Feb. 15, 1992)
Published	33 years, 6 months ago (Feb. 15, 1992)
Published Print	33 years, 6 months ago (Feb. 15, 1992)

Funders 0

None

BibTeX

@article{Watanabe_Fukunaga_1992, title={The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.}, volume={148}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.148.4.1274}, DOI={10.4049/jimmunol.148.4.1274}, number={4}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Watanabe-Fukunaga, R and Brannan, C I and Itoh, N and Yonehara, S and Copeland, N G and Jenkins, N A and Nagata, S}, year={1992}, month=feb, pages={1274–1279} }

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