DOI: 10.4049/jimmunol.140.4.1063. T cell recognition of fibrinogen. A determinant on the A <i>alpha</i>-chain does not require processing.

T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing.

10.4049/jimmunol.140.4.1063

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Murine T cell hybridomas were used to examine the requirements for processing and presentation of human fibrinogen. In contrast to most protein Ag, fibrinogen (Mr 340,000) did not need to be processed by an APC, inasmuch as intact fibrinogen was presented by both pre-fixed and chloroquine-treated macrophages. Through the use of a variety of protease inhibitors, no involvement of proteases either on the macrophage surface or in the culture medium in the presentation of fibrinogen was observed. The epitope recognized by two T cell hybridomas was localized to the peptide, A alpha (551-578), which was located on the carboxy portion of the A alpha-chain. This portion of the A alpha-chain has no defined secondary structure and must possess the conformational flexibility which allows it to directly associate with an I-Ek molecule. Thus conformational flexibility may be a major factor in determining the processing requirements of a protein Ag.

Bibliography

Lee, P., Matsueda, G. R., & Allen, P. M. (1988). T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing. The Journal of Immunology, 140(4), 1063â1068.

Authors 3

P Lee (first)
G R Matsueda (additional)
P M Allen (additional)

References 0 Referenced 73

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 12:36 a.m.)
Deposited	5 months ago (March 29, 2025, 11:24 p.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:23 p.m.)
Issued	37 years, 7 months ago (Feb. 1, 1988)
Published	37 years, 7 months ago (Feb. 1, 1988)
Published Online	37 years, 6 months ago (Feb. 15, 1988)
Published Print	37 years, 6 months ago (Feb. 15, 1988)

Funders 0

None

BibTeX

@article{Lee_1988, title={T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing.}, volume={140}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.140.4.1063}, DOI={10.4049/jimmunol.140.4.1063}, number={4}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Lee, P and Matsueda, G R and Allen, P M}, year={1988}, month=feb, pages={1063–1068} }

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