DOI: 10.4049/jimmunol.140.1.52. Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

10.4049/jimmunol.140.1.52

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The nonobese diabetic mouse is a model of spontaneous type I diabetes mellitus. It is possible to induce diabetes in young, irradiated nonobese diabetic mice by using adoptive transfer of splenocytes or splenic T cells obtained from diabetic donors. This study demonstrates that the induction of diabetes in the adoptive transfer system is dependent on both the L3T4+ and Lyt-2+ subsets of T cells. Neither of these T cell subsets alone mediates the development of severe insulitis or diabetes when adoptively transferred to young, irradiated recipients. In addition, we show that both the L3T4+ and Lyt-2+ subsets must be obtained from diabetic donors in order to transfer diabetes; neither subset can be replaced with cells obtained from young, nondiabetic donors.

Bibliography

Miller, B. J., Appel, M. C., OâNeil, J. J., & Wicker, L. S. (1988). Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. The Journal of Immunology, 140(1), 52â58.

Authors 4

B J Miller (first)
M C Appel (additional)
J J O'Neil (additional)
L S Wicker (additional)

References 0 Referenced 325

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 12:12 p.m.)
Deposited	8 months ago (Jan. 2, 2025, 12:03 p.m.)
Indexed	2 months, 1 week ago (June 27, 2025, 9:46 a.m.)
Issued	37 years, 8 months ago (Jan. 1, 1988)
Published	37 years, 8 months ago (Jan. 1, 1988)
Published Print	37 years, 8 months ago (Jan. 1, 1988)

Funders 0

None

BibTeX

@article{Miller_1988, title={Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.}, volume={140}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.140.1.52}, DOI={10.4049/jimmunol.140.1.52}, number={1}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Miller, B J and Appel, M C and O’Neil, J J and Wicker, L S}, year={1988}, month=jan, pages={52–58} }

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