DOI: 10.4049/jimmunol.139.8.2788. Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice.

Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice.

10.4049/jimmunol.139.8.2788

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Ultraviolet B irradiation (280 to 320 nm) of mice at the site of intradermal infection with herpes simplex virus type 2 increased the severity of the herpes simplex virus type 2 disease and decreased delayed-type hypersensitivity (DTH) responses to viral antigen. Decrease in DTH resulted from the induction of suppressor T cells, as evidenced by the ability of spleen cells from UV-irradiated mice to inhibit DTH and proliferative responses after adoptive transfer. Lymph node cells from UV-irradiated animals did not transfer suppression. DTH was suppressed at the induction but not the expression phase. Suppressor T cells were Lyt-1+, L3T4+, and their activity was antigen-specific. However, after in vitro culture of spleen cells from UV-irradiated mice with herpes simplex virus type 2 antigen, suppressor activity was mediated by Lyt-2+ cells. Culture supernatants contained soluble nonantigen-specific suppressive factors.

Bibliography

Yasumoto, S., Hayashi, Y., & Aurelian, L. (1987). Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice. The Journal of Immunology, 139(8), 2788â2793.

Authors 3

S Yasumoto (first)
Y Hayashi (additional)
L Aurelian (additional)

References 0 Referenced 48

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 12:19 a.m.)
Deposited	5 months ago (March 31, 2025, 4:44 p.m.)
Indexed	5 months ago (April 1, 2025, 12:12 a.m.)
Issued	37 years, 11 months ago (Oct. 1, 1987)
Published	37 years, 11 months ago (Oct. 1, 1987)
Published Online	37 years, 10 months ago (Oct. 15, 1987)
Published Print	37 years, 10 months ago (Oct. 15, 1987)

Funders 0

None

BibTeX

@article{Yasumoto_1987, title={Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice.}, volume={139}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.139.8.2788}, DOI={10.4049/jimmunol.139.8.2788}, number={8}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Yasumoto, S and Hayashi, Y and Aurelian, L}, year={1987}, month=oct, pages={2788–2793} }

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