DOI: 10.4049/jimmunol.139.2.625. Cell surface T3 expression requires the presence of both <i>alpha</i>- and <i>beta</i>-chains of the T cell receptor.

Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.

10.4049/jimmunol.139.2.625

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract We have identified a surface T3- Jurkat variant which has a defective alpha-chain but which possesses an intact beta-chain. The transfection of a functional mouse alpha-chain into this human T cell induces the expression of surface T3 molecules associated with mouse alpha-human beta-heterodimers detected by anticlonotypic antibodies. Treatment of the transfectant with anti-T3, anti-mouse Ti-alpha, or anti-human Ti-beta antibodies clears all Ti-T3 complexes from the surface. These results demonstrate that functional alpha- and beta-chains are both required for expression of T3 on the cell membrane, and that the Ti heterodimers present and associated with T3 on Jurkat cells involve only alpha- and beta-chains.

Bibliography

Saito, T., Weiss, A., Gunter, K. C., Shevach, E. M., & Germain, R. N. (1987). Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. The Journal of Immunology, 139(2), 625â628.

Authors 5

T Saito (first)
A Weiss (additional)
K C Gunter (additional)
E M Shevach (additional)
R N Germain (additional)

References 0 Referenced 35

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 11:17 p.m.)
Deposited	5 months ago (March 31, 2025, 4:42 p.m.)
Indexed	5 months ago (March 31, 2025, 5:10 p.m.)
Issued	38 years, 2 months ago (July 1, 1987)
Published	38 years, 2 months ago (July 1, 1987)
Published Online	38 years, 1 month ago (July 15, 1987)
Published Print	38 years, 1 month ago (July 15, 1987)

Funders 0

None

BibTeX

@article{Saito_1987, title={Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.}, volume={139}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.139.2.625}, DOI={10.4049/jimmunol.139.2.625}, number={2}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Saito, T and Weiss, A and Gunter, K C and Shevach, E M and Germain, R N}, year={1987}, month=jul, pages={625–628} }

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