Abstract
Abstract Syrian hamsters possess a multigene class I family yet fail to perform several associative immunologic functions. In an attempt to determine whether representative hamster genes are structurally functional, we have cloned two closely linked class I-like genes and determined the complete sequence of the 5' member. Its exon organization is similar to that seen in mouse and man, although only two intracytoplasmic domains are encoded instead of the usual three. Comparison of the predicted amino acid sequence and the 3' untranslated region to mouse and human genes suggest along with the linkage data that the hamster gene may be related to either or both K and Qa region genes but probably not to D and L region genes.
Dates
Type | When |
---|---|
Created | 2 years, 8 months ago (Dec. 30, 2022, 10:20 p.m.) |
Deposited | 5 months ago (March 31, 2025, 4:52 p.m.) |
Indexed | 5 months ago (April 1, 2025, 12:13 a.m.) |
Issued | 39 years, 2 months ago (July 1, 1986) |
Published | 39 years, 2 months ago (July 1, 1986) |
Published Online | 39 years, 2 months ago (July 1, 1986) |
Published Print | 39 years, 2 months ago (July 1, 1986) |
@article{McGuire_1986, title={Structure of a class I gene from Syrian hamster.}, volume={137}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.137.1.366}, DOI={10.4049/jimmunol.137.1.366}, number={1}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={McGuire, K L and Duncan, W R and Tucker, P W}, year={1986}, month=jul, pages={366–372} }