DOI: 10.4049/jimmunol.133.1.273. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

10.4049/jimmunol.133.1.273

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Glucocorticoids suppress the proliferation of human T lymphocytes. Activated T lymphocytes require T cell growth factor (TCGF) for proliferation. TCGF is produced by a subset of T lymphocytes, and this production is regulated at the TCGF mRNA level. Dexamethasone, a synthetic glucocorticoid, strongly inhibits the synthesis of TCGF mRNA in human normal peripheral blood lymphocytes stimulated in culture with phytohemagglutinin. It also inhibits the accumulation of gamma-interferon mRNA in these cells. This dual effect may in part explain some of the immunosuppressive and anti-inflammatory effects of glucocorticoids.

Bibliography

Arya, S. K., Wong-Staal, F., & Gallo, R. C. (1984). Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA. The Journal of Immunology, 133(1), 273â276.

Authors 3

S K Arya (first)
F Wong-Staal (additional)
R C Gallo (additional)

References 0 Referenced 280

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 8:56 p.m.)
Deposited	5 months ago (March 31, 2025, 5:22 p.m.)
Indexed	4 weeks, 2 days ago (Aug. 1, 2025, 12:04 a.m.)
Issued	41 years, 1 month ago (July 1, 1984)
Published	41 years, 1 month ago (July 1, 1984)
Published Online	41 years, 1 month ago (July 1, 1984)
Published Print	41 years, 1 month ago (July 1, 1984)

Funders 0

None

BibTeX

@article{Arya_1984, title={Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.}, volume={133}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.133.1.273}, DOI={10.4049/jimmunol.133.1.273}, number={1}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Arya, S K and Wong-Staal, F and Gallo, R C}, year={1984}, month=jul, pages={273–276} }

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