DOI: 10.4049/jimmunol.130.4.1678. Cellular basis of defective cell-mediated lympholysis in atopic dermatitis.

Cellular basis of defective cell-mediated lympholysis in atopic dermatitis.

10.4049/jimmunol.130.4.1678

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract Peripheral blood lymphocytes (PBL) from patients with atopic dermatitis (A.D.) were examined for their capacity to generate cytotoxic T lymphocytes (CTL) during mixed lymphocyte cultures (MLC). Cell-mediated lympholysis (CML) activity, but not proliferative response during MLC, was significantly decreased (p less than 0.01) in patients with A.D. (n = 19) compared with normal controls (n = 19) or patients with other skin diseases (n = 14). Regression analysis revealed a significant correlation (p less than 0.001) between CML activity and the percentage of circulating T8+ suppressor/cytotoxic T cells. Deficient CML activity in A.D. patients, however, was not corrected when isolated autologous T4+ and T8+ cells were recombined at a normal ratio (2:1) of T4+ to T8+ cells. Examination of CML activity in co-cultures of isolated T4+ and T8+ cells obtained from two A.D. patients and their respective HLA-identical healthy siblings indicated that the defect in CML resided in both the helper/inducer T4+ cells and the effector T8+ cells. The defective cytotoxic T cell function reported in the present study may account for the increased susceptibility of patients with A.D. to develop severe viral infections.

Bibliography

Leung, D. Y. M., Wood, N., Dubey, D., Rhodes, A. R., & Geha, R. S. (1983). Cellular basis of defective cell-mediated lympholysis in atopic dermatitis. The Journal of Immunology, 130(4), 1678â1682.

Authors 5

D Y M Leung (first)
N Wood (additional)
D Dubey (additional)
A R Rhodes (additional)
R S Geha (additional)

References 0 Referenced 31

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 31, 2022, 6:43 p.m.)
Deposited	5 months ago (March 31, 2025, 7:06 p.m.)
Indexed	5 months ago (April 1, 2025, 12:15 a.m.)
Issued	42 years, 5 months ago (April 1, 1983)
Published	42 years, 5 months ago (April 1, 1983)
Published Online	42 years, 5 months ago (April 1, 1983)
Published Print	42 years, 5 months ago (April 1, 1983)

Funders 0

None

BibTeX

@article{Leung_1983, title={Cellular basis of defective cell-mediated lympholysis in atopic dermatitis.}, volume={130}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.130.4.1678}, DOI={10.4049/jimmunol.130.4.1678}, number={4}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Leung, D Y M and Wood, N and Dubey, D and Rhodes, A R and Geha, R S}, year={1983}, month=apr, pages={1678–1682} }

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