DOI: 10.4049/jimmunol.127.2.487. T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.

T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.

10.4049/jimmunol.127.2.487

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The requirement for specific T cell subsets in the in vitro generation of human influenza virus-immune cytotoxic T lymphocyte (CTL) responses was investigated. Peripheral blood T cell populations were identified by and selected for their reactivity with the monoclonal antibodies OKT3, OKT4, and OKT8. Influenza virus-immune CTL effectors are OKT3+, OKT4-, and OKT8+. Analysis of CTL precursors demonstrates that: 1) influenza-immune CTL precursors are OKT3+, OKT4-, and OKT8+; 2) CTL precursors require radioresistant OKT3+ helper T cells in order to generate strong cytotoxic responses; and 3) helper T cells can be obtained from either the OKT4+ or OKT4- populations, but more potent help was generated by the OKT4+ subset. The demonstration of a helper T cell requirement for the generation of influenza virus-immune CTL suggests that helper T cells may be involved in the previously documented HLA-linked Ir gene control of influenza-immune CTL responsiveness.

Bibliography

Biddison, W. E., Sharrow, S. O., & Shearer, G. M. (1981). T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help. The Journal of Immunology, 127(2), 487â491.

Authors 3

W E Biddison (first)
S O Sharrow (additional)
G M Shearer (additional)

References 0 Referenced 52

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 7:53 p.m.)
Deposited	5 months ago (March 31, 2025, 6:31 p.m.)
Indexed	5 months ago (April 1, 2025, 12:14 a.m.)
Issued	44 years, 1 month ago (Aug. 1, 1981)
Published	44 years, 1 month ago (Aug. 1, 1981)
Published Online	44 years, 1 month ago (Aug. 1, 1981)
Published Print	44 years, 1 month ago (Aug. 1, 1981)

Funders 0

None

BibTeX

@article{Biddison_1981, title={T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.}, volume={127}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.127.2.487}, DOI={10.4049/jimmunol.127.2.487}, number={2}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Biddison, W E and Sharrow, S O and Shearer, G M}, year={1981}, month=aug, pages={487–491} }

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