DOI: 10.4049/jimmunol.126.6.2307. Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does <i>not</i> involve I recognition.

Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition.

10.4049/jimmunol.126.6.2307

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract The significance of the dichotomy of MHC antigens was investigated. It was determined that primed helpers directed against allogeneic class 1 antigens (K and D in the mouse) were not restricted to syngeneic class 2 antigens (I in the mouse). Furthermore, the generation of helper T cell-replacing factor by stimulation with K or D antigens was not blocked by Ia antibodies that were effective in blocking the same factors generated in response to I region MHC antigens. It is concluded that class 2 antigens are not recognized during the response of helpers to class 1 antigens, and it is suggested that class 1 and class 2 molecules can perform reciprocal functions.

Bibliography

Swain, S. L. (1981). Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition. The Journal of Immunology, 126(6), 2307â2309.

Authors 1

S L Swain (first)

References 0 Referenced 12

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 7:49 p.m.)
Deposited	5 months ago (March 31, 2025, 6:29 p.m.)
Indexed	5 months ago (April 4, 2025, 4:05 p.m.)
Issued	44 years, 3 months ago (June 1, 1981)
Published	44 years, 3 months ago (June 1, 1981)
Published Online	44 years, 3 months ago (June 1, 1981)
Published Print	44 years, 3 months ago (June 1, 1981)

Funders 0

None

BibTeX

@article{Swain_1981, title={Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition.}, volume={126}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.126.6.2307}, DOI={10.4049/jimmunol.126.6.2307}, number={6}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Swain, S L}, year={1981}, month=jun, pages={2307–2309} }

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