DOI: 10.4049/jimmunol.107.4.971. Mechanisms of Passive Sensitization

10.4049/jimmunol.107.4.971

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Abstract E myeloma protein was injected intracutaneously into monkey skin to produce passive sensitization. The sensitized and nonsensitized sites were challenged with 125I-labeled purified anti-IgE. The results of autoradiography of the tissues indicated that IgE was present on mast cells. When the E myeloma protein was injected intravenously into monkeys, the antigen was detected on mast cells in small intestine, bronchi and omentum but not on other tissue cells. The E myeloma protein was detected on basophil granulocytes in the blood, but not on other leukocytes. Evidence was obtained that both mast cells and basophil granulocytes contain monkey IgE, and that E myeloma protein combines with the same cells upon passive sensitization. IgG was detected on neutrophil granulocytes, monocytes and macrophages but not on mast cells.

Bibliography

Tomioka, H., & Ishizaka, K. (1971). Mechanisms of Passive Sensitization. The Journal of Immunology, 107(4), 971â978.

Authors 2

Hisao Tomioka (first)
Kimishige Ishizaka (additional)

References 0 Referenced 55

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 3:01 p.m.)
Deposited	4 months, 4 weeks ago (April 6, 2025, 11:32 p.m.)
Indexed	1 day, 23 hours ago (Sept. 4, 2025, 9:47 a.m.)
Issued	53 years, 11 months ago (Oct. 1, 1971)
Published	53 years, 11 months ago (Oct. 1, 1971)
Published Online	53 years, 11 months ago (Oct. 1, 1971)
Published Print	53 years, 11 months ago (Oct. 1, 1971)

Funders 0

None

BibTeX

@article{Tomioka_1971, title={Mechanisms of Passive Sensitization}, volume={107}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.107.4.971}, DOI={10.4049/jimmunol.107.4.971}, number={4}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Tomioka, Hisao and Ishizaka, Kimishige}, year={1971}, month=oct, pages={971–978} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:47:01Z",
    "timestamp": 1756993621055,
    "version": "3.40.3"
  },
  "reference-count": 0,
  "publisher": "Oxford University Press (OUP)",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1971,
            10,
            1
          ]
        ],
        "date-time": "1971-10-01T00:00:00Z",
        "timestamp": 55123200000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "https://academic.oup.com/pages/standard-publication-reuse-rights"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1971,
        10,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>E myeloma protein was injected intracutaneously into monkey skin to produce passive sensitization. The sensitized and nonsensitized sites were challenged with 125I-labeled purified anti-IgE. The results of autoradiography of the tissues indicated that IgE was present on mast cells. When the E myeloma protein was injected intravenously into monkeys, the antigen was detected on mast cells in small intestine, bronchi and omentum but not on other tissue cells. The E myeloma protein was detected on basophil granulocytes in the blood, but not on other leukocytes. Evidence was obtained that both mast cells and basophil granulocytes contain monkey IgE, and that E myeloma protein combines with the same cells upon passive sensitization. IgG was detected on neutrophil granulocytes, monocytes and macrophages but not on mast cells.</jats:p>",
  "DOI": "10.4049/jimmunol.107.4.971",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2022,
        12,
        30
      ]
    ],
    "date-time": "2022-12-30T20:01:04Z",
    "timestamp": 1672430464000
  },
  "page": "971-978",
  "source": "Crossref",
  "is-referenced-by-count": 55,
  "title": "Mechanisms of Passive Sensitization",
  "prefix": "10.1093",
  "volume": "107",
  "author": [
    {
      "given": "Hisao",
      "family": "Tomioka",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Medicine and Microbiology, Johns Hopkins University, School of Medicine, and the O'Neill Memorial Laboratories, The Good Samaritan Hospital , Baltimore, Maryland"
        }
      ]
    },
    {
      "given": "Kimishige",
      "family": "Ishizaka",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Medicine and Microbiology, Johns Hopkins University, School of Medicine, and the O'Neill Memorial Laboratories, The Good Samaritan Hospital , Baltimore, Maryland"
        }
      ]
    }
  ],
  "member": "286",
  "published-online": {
    "date-parts": [
      [
        1971,
        10,
        1
      ]
    ]
  },
  "container-title": "The Journal of Immunology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://academic.oup.com/jimmunol/article-pdf/107/4/971/62736672/ji1070040971.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://academic.oup.com/jimmunol/article-pdf/107/4/971/62736672/ji1070040971.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        4,
        7
      ]
    ],
    "date-time": "2025-04-07T03:32:26Z",
    "timestamp": 1743996746000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/jimmunol/article/107/4/971/8094146"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1971,
        10,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1971,
          10,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.4049/jimmunol.107.4.971",
  "relation": {},
  "ISSN": [
    "0022-1767",
    "1550-6606"
  ],
  "subject": [],
  "published-other": {
    "date-parts": [
      [
        1971,
        10
      ]
    ]
  },
  "published": {
    "date-parts": [
      [
        1971,
        10,
        1
      ]
    ]
  }
}