DOI: 10.4049/jimmunol.102.1.117. Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus

Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus

10.4049/jimmunol.102.1.117

Crossref journal-article

Oxford University Press (OUP)

The Journal of Immunology (286)

Abstract

Summary A tissue antigen reactive with sera from SLE patients has been partially characterized. The antigen is a soluble cytoplasmic component which is present in a variety of human tissues and is distinct from known nuclear antigens. It is an acidic macromolecule which has the electrophoretic mobility of an α1 globulin and is resistant to most proteolytic enzymes including trypsin, pepsin and chymotrypsin. Antigenicity is destroyed by 0.02 M periodate and by 0.001 M parahydroxy mercuribenzoate. Antibodies to this antigen have been found in 40% of unselected LE sera and were absent from a large number of sera from normal persons and from the sera of patients with other connective tissue disorders.

Bibliography

Clark, G., Reichlin, M., & Tomasi, T. B. (1969). Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus. The Journal of Immunology, 102(1), 117â122.

Authors 3

Geoffrey Clark (first)
Morris Reichlin (additional)
Thomas B Tomasi (additional)

References 0 Referenced 375

None

Dates

Type	When
Created	2 years, 8 months ago (Dec. 30, 2022, 2:12 p.m.)
Deposited	4 months, 3 weeks ago (April 7, 2025, 12:53 a.m.)
Indexed	4 weeks, 1 day ago (Aug. 1, 2025, 12:04 a.m.)
Issued	56 years, 7 months ago (Jan. 1, 1969)
Published	56 years, 7 months ago (Jan. 1, 1969)
Published Online	56 years, 7 months ago (Jan. 1, 1969)
Published Print	56 years, 7 months ago (Jan. 1, 1969)

Funders 0

None

BibTeX

@article{Clark_1969, title={Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus}, volume={102}, ISSN={1550-6606}, url={http://dx.doi.org/10.4049/jimmunol.102.1.117}, DOI={10.4049/jimmunol.102.1.117}, number={1}, journal={The Journal of Immunology}, publisher={Oxford University Press (OUP)}, author={Clark, Geoffrey and Reichlin, Morris and Tomasi, Thomas B}, year={1969}, month=jan, pages={117–122} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        1
      ]
    ],
    "date-time": "2025-08-01T04:04:25Z",
    "timestamp": 1754021065224,
    "version": "3.40.3"
  },
  "reference-count": 0,
  "publisher": "Oxford University Press (OUP)",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1969,
            1,
            1
          ]
        ],
        "date-time": "1969-01-01T00:00:00Z",
        "timestamp": -31536000000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "https://academic.oup.com/pages/standard-publication-reuse-rights"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1969,
        1,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Summary</jats:title>\n               <jats:p>A tissue antigen reactive with sera from SLE patients has been partially characterized. The antigen is a soluble cytoplasmic component which is present in a variety of human tissues and is distinct from known nuclear antigens. It is an acidic macromolecule which has the electrophoretic mobility of an \u03b11 globulin and is resistant to most proteolytic enzymes including trypsin, pepsin and chymotrypsin. Antigenicity is destroyed by 0.02 M periodate and by 0.001 M parahydroxy mercuribenzoate. Antibodies to this antigen have been found in 40% of unselected LE sera and were absent from a large number of sera from normal persons and from the sera of patients with other connective tissue disorders.</jats:p>",
  "DOI": "10.4049/jimmunol.102.1.117",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2022,
        12,
        30
      ]
    ],
    "date-time": "2022-12-30T19:12:48Z",
    "timestamp": 1672427568000
  },
  "page": "117-122",
  "source": "Crossref",
  "is-referenced-by-count": 375,
  "title": "Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus",
  "prefix": "10.1093",
  "volume": "102",
  "author": [
    {
      "given": "Geoffrey",
      "family": "Clark",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Medicine, State University of New York at Buffalo , Buffalo, New York"
        }
      ]
    },
    {
      "given": "Morris",
      "family": "Reichlin",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Medicine, State University of New York at Buffalo , Buffalo, New York"
        }
      ]
    },
    {
      "suffix": "Jr.",
      "given": "Thomas B",
      "family": "Tomasi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Medicine, State University of New York at Buffalo , Buffalo, New York"
        }
      ]
    }
  ],
  "member": "286",
  "published-online": {
    "date-parts": [
      [
        1969,
        1,
        1
      ]
    ]
  },
  "container-title": "The Journal of Immunology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://academic.oup.com/jimmunol/article-pdf/102/1/117/62750885/ji1020010117.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://academic.oup.com/jimmunol/article-pdf/102/1/117/62750885/ji1020010117.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        4,
        7
      ]
    ],
    "date-time": "2025-04-07T04:53:41Z",
    "timestamp": 1744001621000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/jimmunol/article/102/1/117/8096914"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1969,
        1,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1969,
          1,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.4049/jimmunol.102.1.117",
  "relation": {},
  "ISSN": [
    "0022-1767",
    "1550-6606"
  ],
  "subject": [],
  "published-other": {
    "date-parts": [
      [
        1969,
        1
      ]
    ]
  },
  "published": {
    "date-parts": [
      [
        1969,
        1,
        1
      ]
    ]
  }
}