DOI: 10.3171/jns.1995.83.5.0812. Cerebral arterial aneurysm formation and rupture in 20,767 elderly patients: hypertension and other risk factors

Cerebral arterial aneurysm formation and rupture in 20,767 elderly patients: hypertension and other risk factors

10.3171/jns.1995.83.5.0812

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ Cerebral arterial aneurysms are common in the general population and their rupture is a catastrophic event. Considerable uncertainty remains concerning the conditions that predispose individuals to aneurysm formation or rupture. The role of systemic hypertension in aneurysm formation and rupture has been especially controversial. Demographic variables have rarely been addressed because of the small sample sizes in previous studies. The authors describe the demographics and prevalence of hypertension in 20,767 Medicare patients with an unruptured aneurysm and compare these to a random sample of the hospitalized Medicare population. The prevalence of hypertension in patients with unruptured aneurysms was 43.2% compared with 34.4% in the random sample. Patients who survived their initial hospitalization were separated into two groups: those with an unruptured cerebral aneurysm as the primary diagnosis and those with an unruptured cerebral aneurysm as a secondary diagnosis. Follow-up data for 18,119 patients were examined to determine the risk of subarachnoid hemorrhage (SAH) associated with age, gender, race, hypertension, insulin-dependent diabetes mellitus, and surgical treatment. For patients with an unruptured cerebral aneurysm as the primary diagnosis, hypertension was found to be a significant risk factor for future SAH (risk ratio: 1.46, 95% confidence interval (CI): 1.01–2.11), whereas surgical treatment (risk ratio: 0.29, 95% CI: 0.09–0.97) had a significant protective effect. Advancing age had a small but significant protective effect in both groups. Elderly patients identified with unruptured aneurysms are more likely to have coexisting hypertension than the general hospitalized population. In elderly patients hospitalized with an unruptured cerebral aneurysm as their primary diagnosis, hypertension is a risk factor for subsequent SAH, whereas surgical treatment is a protective factor against SAH.

Bibliography

Taylor, C. L., Yuan, Z., Selman, W. R., Ratcheson, R. A., & Rimm, A. A. (1995). Cerebral arterial aneurysm formation and rupture in 20,767 elderly patients: hypertension and other risk factors. Journal of Neurosurgery, 83(5), 812â819.

Authors 5

Christopher L. Taylor (first)
Zhong Yuan (additional)
Warren R. Selman (additional)
Robert A. Ratcheson (additional)
Alfred A. Rimm (additional)

References 57 Referenced 142

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Dates

Type	When
Created	16 years, 2 months ago (June 2, 2009, 1:42 p.m.)
Deposited	3 years, 3 months ago (May 14, 2022, 1:21 a.m.)
Indexed	1 month ago (July 23, 2025, 8:41 a.m.)
Issued	29 years, 9 months ago (Nov. 1, 1995)
Published	29 years, 9 months ago (Nov. 1, 1995)
Published Print	29 years, 9 months ago (Nov. 1, 1995)

Funders 0

None

BibTeX

@article{Taylor_1995, title={Cerebral arterial aneurysm formation and rupture in 20,767 elderly patients: hypertension and other risk factors}, volume={83}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1995.83.5.0812}, DOI={10.3171/jns.1995.83.5.0812}, number={5}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Taylor, Christopher L. and Yuan, Zhong and Selman, Warren R. and Ratcheson, Robert A. and Rimm, Alfred A.}, year={1995}, month=nov, pages={812–819} }

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