DOI: 10.3171/jns.1990.73.4.0601. Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbit

Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbit

10.3171/jns.1990.73.4.0601

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ The authors describe a method for Doppler ultrasound recording of flow velocity in the basilar artery of normal rabbits and rabbits with experimental subarachnoid hemorrhage (SAH). With this transcranial Doppler (TCD) model, clinical assumptions regarding flow velocity/cerebral blood flow (CBF) relationships, autoregulatory responses, and Doppler spectral waveform analysis can be tested under controlled conditions and compared with established methods of CBF measurement (hydrogen clearance). The time course of changes in flow velocity following SAH (cerebral vasospasm) is successfully demonstrated using the experimental TCD method. There are significant differences in the flow velocity and CBF responses to hypercapnia, hypocapnia, and trimethaphan-induced hypotension which indicate that TCD cannot be considered a simple alternative to CBF measurement for the study of cerebrovascular reactivity and cerebral autoregulation.

Bibliography

Nelson, R. J., Perry, S., Hames, T. K., & Pickard, J. D. (1990). Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbit. Journal of Neurosurgery, 73(4), 601â610.

Authors 4

Richard J. Nelson (first)
Sheila Perry (additional)
Tony K. Hames (additional)
John D. Pickard (additional)

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Dates

Type	When
Created	16 years, 3 months ago (May 13, 2009, 2:20 p.m.)
Deposited	2 years, 5 months ago (March 19, 2023, 9:46 p.m.)
Indexed	3 months, 1 week ago (May 19, 2025, 8:08 a.m.)
Issued	34 years, 11 months ago (Oct. 1, 1990)
Published	34 years, 11 months ago (Oct. 1, 1990)
Published Print	34 years, 11 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Nelson_1990, title={Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbit}, volume={73}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1990.73.4.0601}, DOI={10.3171/jns.1990.73.4.0601}, number={4}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Nelson, Richard J. and Perry, Sheila and Hames, Tony K. and Pickard, John D.}, year={1990}, month=oct, pages={601–610} }

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