DOI: 10.3171/jns.1989.71.3.0335. Prognostic implications of the bromodeoxyuridine labeling index of human gliomas

Prognostic implications of the bromodeoxyuridine labeling index of human gliomas

10.3171/jns.1989.71.3.0335

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ This study includes 182 patients with intracranial gliomas who received bromodeoxyuridine (BUdR), 200 mg/sq m intravenously, at the time of craniotomy but before tumor biopsy. The tumor specimens were stained for BUdR using the immunoperoxidase method; the BUdR labeling index (LI), or S-phase fraction, was calculated as the percentage of BUdR-positive cells. The median BUdR LI's for 127 primary moderately anaplastic astrocytomas, highly anaplastic astrocytomas, and glioblastomas (< 1%, 2.7%, and 7.3%, respectively; range 0% to 38.1%) were not significantly different from those of 55 similar recurrent tumors (< 1%, 4.3%, and 7.4%, respectively; range 0% to 30.5%). The mean LI was significantly higher in tumors from patients over 50 years of age than in tumors from younger patients (p < 0.001). This age-related difference in LI's was found in both groups of patients with astrocytomas but not in those with glioblastomas. Kaplan-Meier survival curves showed a significantly greater probability of survival among patients whose tumors had LI's of less than 1% than among those with LI's greater than 5%; survival probability of patients with tumor LI's of 1% to 5% was intermediate between the two extremes. Thus, the BUdR LI appears to reflect the proliferative potential more accurately than the histopathological diagnosis and should therefore be considered an important factor in determining the prognosis of individual patients with intracranial gliomas and in selecting their treatment.

Bibliography

Hoshino, T., Prados, M., Wilson, C. B., Cho, K. G., Lee, K.-S., & Davis, R. L. (1989). Prognostic implications of the bromodeoxyuridine labeling index of human gliomas. Journal of Neurosurgery, 71(3), 335â341.

Authors 6

Takao Hoshino (first)
Michael Prados (additional)
Charles B. Wilson (additional)
Kyung Gi Cho (additional)
Kyu-Sung Lee (additional)
Richard L. Davis (additional)

References 27 Referenced 135

10.2214/ajr.105.1.43 / AJR / The treatment and prognosis of medulloblastoma in children. A study of 82 verified cases. by Bloom (1969)
10.1007/BF01813556 / Acta Neurochir / Optimal therapy in medulloblastoma. by Bongartz (1979)
{'key': 'b3', 'series-title': 'J Neurooncol', 'first-page': '53', 'article-title': 'Early response and long-term results in the radiotherapy of childhood medulloblastoma.', 'volume': '1', 'author': 'Chin', 'year': '1983'} / J Neurooncol / Early response and long-term results in the radiotherapy of childhood medulloblastoma. by Chin (1983)
10.3171/jns.1986.65.6.0790 / J Neurosurg / The prediction of tumor doubling time in recurrent meningiomas. Cell kinetics studies with bromodeoxyuridine labeling. by Cho (1986)
10.1007/BF02228885 / J Neurooncol / Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors. by Cohandon (1985)
10.1002/1097-0142(197903)43:3<1014::AID-CNCR2820430334>3.0.CO;2-9 / Cancer / Medulloblastoma. Treatment results and effect on normal tissue. by Cumberlin (1979)
{'key': 'b7', 'series-title': 'J Neurooncol', 'first-page': '267', 'article-title': 'Correlation of survival and diagnosis in supratentorial malignant gliomas.', 'volume': '2', 'author': 'Davis', 'year': '1984'} / J Neurooncol / Correlation of survival and diagnosis in supratentorial malignant gliomas. by Davis (1984)
10.1007/BF01401236 / Acta Neurochir / Proliferative activity of meningiomas as evaluated by bromodeoxyuridine uptake examination. by Fukui (1986)
{'key': 'b9', 'series-title': 'Pharmacol Rev', 'first-page': '249', 'article-title': 'The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells.', 'volume': '29', 'author': 'Goz', 'year': '1978'} / Pharmacol Rev / The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells. by Goz (1978)
10.1126/science.7123245 / Science / Monoclonal antibody of 5-bromo- and 5-iododeoxyuridine: a new reagent for detection of DNA replication. by Gratzner (1982)
10.1007/BF01406016 / Acta Neurochir / Medulloblastoma in childhood. Survival and functional results. by Hirsch (1979)
10.1002/1097-0142(19850415)55:8<1711::AID-CNCR2820550816>3.0.CO;2-R / Cancer / A cell kinetic study on medulloblastomas. by Hoshino (1985)
10.1002/ijc.2910380311 / Int J Cancer / S-phase fraction of human brain tumors in situ measured by uptake of bromodeoxyuridine. by Hoshino (1986)
{'key': 'b14', 'series-title': 'J Neurooncol', 'article-title': 'Variability in the proliferative potential of human gliomas.', 'author': 'Hoshino'} / J Neurooncol / Variability in the proliferative potential of human gliomas. by Hoshino
10.3171/jns.1986.64.3.0453 / J Neurosurg / In situ cell kinetics studies on human neuroectodermal tumors using bromodeoxyuridine. by Hoshino (1986)
10.1002/1097-0142(19861001)58:7<1466::AID-CNCR2820580715>3.0.CO;2-W / Cancer / Proliferative potential of human meningiomas of brain. A cell kinetic study with bromodeoxyuridine. by Hoshino (1986)
10.3171/jns.1988.69.6.0839 / J Neurosurg / Prognostic implications of the proliferative potential of low-grade astrocytomas. by Hoshino (1988)
10.1007/BF00688188 / Acta Neuropathol / Cell kinetics of the malignant evolution of meningothelial meningioma. by Iwaki (1987)
10.3171/jns.1984.61.4.0665 / J Neurosurg / Neurosurgical management of low-grade astrocytoma of the cerebral hemispheres. by Laws (1984)
{'key': 'b20', 'series-title': 'Acta Neuropathol', 'first-page': '155', 'article-title': 'Immunocytochemical demonstration of S-phase cells by anti bromodeoxyuridine monoclonal antibody in huma brain tumor tissues.', 'volume': '67', 'author': 'Nagashima', 'year': '19'} / Acta Neuropathol / Immunocytochemical demonstration of S-phase cells by anti bromodeoxyuridine monoclonal antibody in huma brain tumor tissues. by Nagashima (19)
10.1002/1097-0142(19880615)61:12<2433::AID-CNCR2820611207>3.0.CO;2-A / Cancer / The proliferative potential of human ependymomas measured by in situ bromodeoxyuridine labeling. by Nagashima (1988)
10.3171/jns.1983.58.4.0543 / J Neurosurg / Medulloblastoma: clinical presentation and management. Experience at the Hospital For Sick Children, Toronto, 1950–1980. by Park (1983)
10.3171/jns.1987.67.2.0177 / J Neurosurg / Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres. by Piepmeier (1987)
10.1002/1097-0142(197901)43:1<129::AID-CNCR2820430120>3.0.CO;2-Y / Cancer / Cerebellar medulloblastoma: results of a new method of radiation treatment. by Tokars (1979)
10.1002/cyto.990070602 / Cytometry / Improved high-affinity monoclonal antibody to iododeoxyuridine. by Vanderlaan (1986)
10.1016/0360-3016(79)90553-4 / Int J Radiat Oncol Biol Phys / An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. by Walker (1979)
10.1017/S0317167100025993 / Can J Neurol Sci / The relative significance of factors affecting postoperative survival in astrocytomas, grades one and two. by Weir (1976)

Dates

Type	When
Created	16 years, 3 months ago (May 8, 2009, 12:23 p.m.)
Deposited	2 years, 5 months ago (March 26, 2023, 5:26 p.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 12:48 a.m.)
Issued	35 years, 11 months ago (Sept. 1, 1989)
Published	35 years, 11 months ago (Sept. 1, 1989)
Published Print	35 years, 11 months ago (Sept. 1, 1989)

Funders 0

None

BibTeX

@article{Hoshino_1989, title={Prognostic implications of the bromodeoxyuridine labeling index of human gliomas}, volume={71}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1989.71.3.0335}, DOI={10.3171/jns.1989.71.3.0335}, number={3}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Hoshino, Takao and Prados, Michael and Wilson, Charles B. and Cho, Kyung Gi and Lee, Kyu-Sung and Davis, Richard L.}, year={1989}, month=sep, pages={335–341} }

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