DOI: 10.3171/jns.1988.68.1.0073. Plasminogen activator activity and molecular weight patterns in human brain tumors

Plasminogen activator activity and molecular weight patterns in human brain tumors

10.3171/jns.1988.68.1.0073

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ Fresh human brain-tumor samples were assayed for their plasminogen activator (PA) content. Specific molecular weight patterns were identified for each of five common brain tumors and for normal brain, suggesting a cell-specific origin of the various PA forms. Malignant tumors contained higher PA activity and a larger number of molecular weight patterns than benign tumors, with the exception of acoustic neurinomas. Irradiated tumors contained lower PA activity than nonirradiated tumors. Finally, a slight but definite correlation between brain edema and PA activity was detected. The future role of brain-tumor PA's for diagnostic and therapeutic purposes is discussed.

Bibliography

Sawaya, R., & Highsmith, R. (1988). Plasminogen activator activity and molecular weight patterns in human brain tumors. Journal of Neurosurgery, 68(1), 73â79.

Authors 2

Raymond Sawaya (first)
Robert Highsmith (additional)

References 47 Referenced 38

10.1111/j.1749-6632.1981.tb29766.x / Ann NY Acad Sci by Bernik MB (1981)
{'key': 'b2', 'first-page': '542', 'volume': '16', 'author': 'Böck F', 'year': '1970', 'journal-title': 'Neurochirurgie'} / Neurochirurgie by Böck F (1970)
10.1182/blood.V61.2.267.267 / Blood by Booth NA (1983)
10.1055/s-0038-1653437 / Thromb Haemost by Bykowska K (1981)
10.1084/jem.13.5.571 / J Exp Med by Carrel A (1911)
{'key': 'b6', 'first-page': '433', 'volume-title': 'Biological Markers of Neoplasia: Basic and Applied Aspects.', 'author': 'Christman JK', 'year': '1978'} / Biological Markers of Neoplasia: Basic and Applied Aspects. by Christman JK (1978)
{'key': 'b7', 'first-page': '2971', 'volume': '44', 'author': 'Colombi M', 'year': '1984', 'journal-title': 'Cancer Res'} / Cancer Res by Colombi M (1984)
10.1177/30.11.6183313 / J Histochem Cytochem by Danø K (1982)
10.1002/ijc.2910330503 / Int J Cancer by DePetro G (1984)
10.1126/science.170.3962.1095 / Science by Deutsch DG (1970)
{'key': 'b11', 'first-page': '219', 'volume': '42', 'author': 'Evers JL', 'year': '1982', 'journal-title': 'Cancer Res'} / Cancer Res by Evers JL (1982)
10.1158/jcr.1925.62 / J Cancer Res by Fischer A (1925)
10.1016/0049-3848(78)90228-1 / Thromb Res by Gerdin B (1978)
10.1097/00006123-198306000-00001
10.1016/0167-4838(82)90067-X / Biochim Biophys Acta by Gilbert LC (1982)
10.1038/259399a0 / Nature by Girmann G (1976)
10.2307/3576107 / Radiat Res by Henderson BW (1983)
10.1002/jcp.1041040209 / J Cell Physiol by Hince TA (1980)
10.1038/bjc.1978.63 / Br J Cancer by Hince TA (1978)
{'key': 'b20', 'first-page': '105', 'volume': '23', 'author': 'Jensen RH', 'year': '1979', 'journal-title': 'Acta Cytol'} / Acta Cytol by Jensen RH (1979)
10.1038/227680a0 / Nature by Laemmli UK (1970)
10.1016/0022-510X(82)90032-6 / J Neurol Sci by Liepkalns VA (1982)
10.1055/s-0028-1087134 / Semin Thromb Hemost by Lisiewicz J (1978)
10.1016/S0021-9258(19)52451-6 / J Biol Chem by Lowry OH (1951)
10.1016/0022-4804(79)90054-4 / J Surg Res by Malone JM (1979)
10.1212/WNL.27.7.650 / Neurology by Mandybur TI (1979)
10.1016/0306-9877(83)90116-0 / Med Hypotheses by Ng R (1983)
10.1021/bi00268a014 / Biochemistry by Nielsen LS (1982)
10.1016/0092-8674(83)90093-4 / Cell by Ossowski L (1983)
10.1084/jem.137.1.112 / J Exp Med by Ossowski L (1973)
10.4049/jimmunol.128.4.1595 / J Immunol by Plow EF (1982)
{'key': 'b32', 'first-page': '491', 'volume-title': 'Biological Markers of Neoplasia: Basic and Applied Aspects.', 'author': 'Reich E', 'year': '1978'} / Biological Markers of Neoplasia: Basic and Applied Aspects. by Reich E (1978)
{'key': 'b33', 'first-page': '421', 'volume-title': 'Biological Markers of Neoplasia: Basic and Applied Aspects.', 'author': 'Roblin R', 'year': '1978'} / Biological Markers of Neoplasia: Basic and Applied Aspects. by Roblin R (1978)
10.1016/0167-4838(83)90172-3 / Biochim Biophys Acta by Roche PC (1983)
10.1002/ijc.2910300520 / Int J Cancer by Salo T (1982)
10.3171/jns.1986.64.2.0263
10.1016/0006-8993(81)90138-4 / Brain Res by Soreq H (1981)
10.1007/BF02358887 / Experientia by Tovi D (1975)
{'key': 'b39', 'first-page': '297', 'volume': '38', 'author': 'Tucker WS', 'year': '1978', 'journal-title': 'Cancer Res'} / Cancer Res by Tucker WS (1978)
10.1084/jem.137.1.85 / J Exp Med by Unkeless JC (1973)
10.1016/S0021-9258(17)37840-7 / J Biol Chem by Vetterlein D (1979)
{'key': 'b42', 'first-page': '715', 'volume': '45', 'author': 'Wainberg MA', 'year': '1982', 'journal-title': 'Immunology'} / Immunology by Wainberg MA (1982)
10.1097/00006123-198204000-00004
{'key': 'b44', 'first-page': '933', 'volume': '40', 'author': 'Wilson EL', 'year': '1980', 'journal-title': 'Cancer Res'} / Cancer Res by Wilson EL (1980)
10.1016/B978-0-08-022628-6.50017-8 / Regulatory Proteolytic Enzymes and Their Inhibitors. by Wilson EL (1978)
{'key': 'b46', 'first-page': '387', 'volume': '25', 'author': 'Zänker KS', 'year': '1980', 'journal-title': 'Cell Mol Biol'} / Cell Mol Biol by Zänker KS (1980)
10.1016/0022-510X(78)90246-0

Dates

Type	When
Created	16 years, 3 months ago (May 8, 2009, 12:21 p.m.)
Deposited	1 year, 5 months ago (March 13, 2024, 2:22 a.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:56 p.m.)
Issued	37 years, 7 months ago (Jan. 1, 1988)
Published	37 years, 7 months ago (Jan. 1, 1988)
Published Print	37 years, 7 months ago (Jan. 1, 1988)

Funders 0

None

BibTeX

@article{Sawaya_1988, title={Plasminogen activator activity and molecular weight patterns in human brain tumors}, volume={68}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1988.68.1.0073}, DOI={10.3171/jns.1988.68.1.0073}, number={1}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Sawaya, Raymond and Highsmith, Robert}, year={1988}, month=jan, pages={73–79} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        12
      ]
    ],
    "date-time": "2025-07-12T22:56:01Z",
    "timestamp": 1752360961568
  },
  "reference-count": 47,
  "publisher": "Journal of Neurosurgery Publishing Group (JNSPG)",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1988,
        1
      ]
    ]
  },
  "abstract": "<jats:p content-type=\"fine-print\">\u2713 Fresh human brain-tumor samples were assayed for their plasminogen activator (PA) content. Specific molecular weight patterns were identified for each of five common brain tumors and for normal brain, suggesting a cell-specific origin of the various PA forms. Malignant tumors contained higher PA activity and a larger number of molecular weight patterns than benign tumors, with the exception of acoustic neurinomas. Irradiated tumors contained lower PA activity than nonirradiated tumors. Finally, a slight but definite correlation between brain edema and PA activity was detected. The future role of brain-tumor PA's for diagnostic and therapeutic purposes is discussed.</jats:p>",
  "DOI": "10.3171/jns.1988.68.1.0073",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2009,
        5,
        8
      ]
    ],
    "date-time": "2009-05-08T16:21:29Z",
    "timestamp": 1241799689000
  },
  "page": "73-79",
  "source": "Crossref",
  "is-referenced-by-count": 38,
  "title": "Plasminogen activator activity and molecular weight patterns in human brain tumors",
  "prefix": "10.3171",
  "volume": "68",
  "author": [
    {
      "given": "Raymond",
      "family": "Sawaya",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Robert",
      "family": "Highsmith",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "1754",
  "reference": [
    {
      "key": "b1",
      "doi-asserted-by": "crossref",
      "first-page": "592",
      "DOI": "10.1111/j.1749-6632.1981.tb29766.x",
      "volume": "370",
      "author": "Bernik MB",
      "year": "1981",
      "journal-title": "Ann NY Acad Sci"
    },
    {
      "key": "b2",
      "first-page": "542",
      "volume": "16",
      "author": "B\u00f6ck F",
      "year": "1970",
      "journal-title": "Neurochirurgie"
    },
    {
      "key": "b3",
      "doi-asserted-by": "crossref",
      "first-page": "267",
      "DOI": "10.1182/blood.V61.2.267.267",
      "volume": "61",
      "author": "Booth NA",
      "year": "1983",
      "journal-title": "Blood"
    },
    {
      "key": "b4",
      "doi-asserted-by": "crossref",
      "first-page": "642",
      "DOI": "10.1055/s-0038-1653437",
      "volume": "46",
      "author": "Bykowska K",
      "year": "1981",
      "journal-title": "Thromb Haemost"
    },
    {
      "key": "b5",
      "doi-asserted-by": "crossref",
      "first-page": "571",
      "DOI": "10.1084/jem.13.5.571",
      "volume": "13",
      "author": "Carrel A",
      "year": "1911",
      "journal-title": "J Exp Med"
    },
    {
      "key": "b6",
      "first-page": "433",
      "volume-title": "Biological Markers of Neoplasia: Basic and Applied Aspects.",
      "author": "Christman JK",
      "year": "1978"
    },
    {
      "key": "b7",
      "first-page": "2971",
      "volume": "44",
      "author": "Colombi M",
      "year": "1984",
      "journal-title": "Cancer Res"
    },
    {
      "key": "b8",
      "doi-asserted-by": "crossref",
      "first-page": "1165",
      "DOI": "10.1177/30.11.6183313",
      "volume": "30",
      "author": "Dan\u00f8 K",
      "year": "1982",
      "journal-title": "J Histochem Cytochem"
    },
    {
      "key": "b9",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1002/ijc.2910330503",
      "volume": "33",
      "author": "DePetro G",
      "year": "1984",
      "journal-title": "Int J Cancer"
    },
    {
      "key": "b10",
      "doi-asserted-by": "crossref",
      "first-page": "1095",
      "DOI": "10.1126/science.170.3962.1095",
      "volume": "170",
      "author": "Deutsch DG",
      "year": "1970",
      "journal-title": "Science"
    },
    {
      "key": "b11",
      "first-page": "219",
      "volume": "42",
      "author": "Evers JL",
      "year": "1982",
      "journal-title": "Cancer Res"
    },
    {
      "key": "b12",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1158/jcr.1925.62",
      "volume": "9",
      "author": "Fischer A",
      "year": "1925",
      "journal-title": "J Cancer Res"
    },
    {
      "key": "b13",
      "doi-asserted-by": "crossref",
      "first-page": "995",
      "DOI": "10.1016/0049-3848(78)90228-1",
      "volume": "13",
      "author": "Gerdin B",
      "year": "1978",
      "journal-title": "Thromb Res"
    },
    {
      "key": "b14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00006123-198306000-00001"
    },
    {
      "key": "b15",
      "doi-asserted-by": "crossref",
      "first-page": "450",
      "DOI": "10.1016/0167-4838(82)90067-X",
      "volume": "704",
      "author": "Gilbert LC",
      "year": "1982",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "b16",
      "doi-asserted-by": "crossref",
      "first-page": "399",
      "DOI": "10.1038/259399a0",
      "volume": "259",
      "author": "Girmann G",
      "year": "1976",
      "journal-title": "Nature"
    },
    {
      "key": "b17",
      "doi-asserted-by": "crossref",
      "first-page": "646",
      "DOI": "10.2307/3576107",
      "volume": "95",
      "author": "Henderson BW",
      "year": "1983",
      "journal-title": "Radiat Res"
    },
    {
      "key": "b18",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1002/jcp.1041040209",
      "volume": "104",
      "author": "Hince TA",
      "year": "1980",
      "journal-title": "J Cell Physiol"
    },
    {
      "key": "b19",
      "doi-asserted-by": "crossref",
      "first-page": "424",
      "DOI": "10.1038/bjc.1978.63",
      "volume": "37",
      "author": "Hince TA",
      "year": "1978",
      "journal-title": "Br J Cancer"
    },
    {
      "key": "b20",
      "first-page": "105",
      "volume": "23",
      "author": "Jensen RH",
      "year": "1979",
      "journal-title": "Acta Cytol"
    },
    {
      "key": "b21",
      "doi-asserted-by": "crossref",
      "first-page": "680",
      "DOI": "10.1038/227680a0",
      "volume": "227",
      "author": "Laemmli UK",
      "year": "1970",
      "journal-title": "Nature"
    },
    {
      "key": "b22",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1016/0022-510X(82)90032-6",
      "volume": "57",
      "author": "Liepkalns VA",
      "year": "1982",
      "journal-title": "J Neurol Sci"
    },
    {
      "key": "b23",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1055/s-0028-1087134",
      "volume": "4",
      "author": "Lisiewicz J",
      "year": "1978",
      "journal-title": "Semin Thromb Hemost"
    },
    {
      "key": "b24",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1016/S0021-9258(19)52451-6",
      "volume": "193",
      "author": "Lowry OH",
      "year": "1951",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "b25",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1016/0022-4804(79)90054-4",
      "volume": "26",
      "author": "Malone JM",
      "year": "1979",
      "journal-title": "J Surg Res"
    },
    {
      "key": "b26",
      "doi-asserted-by": "crossref",
      "first-page": "650",
      "DOI": "10.1212/WNL.27.7.650",
      "volume": "27",
      "author": "Mandybur TI",
      "year": "1979",
      "journal-title": "Neurology"
    },
    {
      "key": "b27",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1016/0306-9877(83)90116-0",
      "volume": "10",
      "author": "Ng R",
      "year": "1983",
      "journal-title": "Med Hypotheses"
    },
    {
      "key": "b28",
      "doi-asserted-by": "crossref",
      "first-page": "6410",
      "DOI": "10.1021/bi00268a014",
      "volume": "21",
      "author": "Nielsen LS",
      "year": "1982",
      "journal-title": "Biochemistry"
    },
    {
      "key": "b29",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1016/0092-8674(83)90093-4",
      "volume": "35",
      "author": "Ossowski L",
      "year": "1983",
      "journal-title": "Cell"
    },
    {
      "key": "b30",
      "doi-asserted-by": "crossref",
      "first-page": "112",
      "DOI": "10.1084/jem.137.1.112",
      "volume": "137",
      "author": "Ossowski L",
      "year": "1973",
      "journal-title": "J Exp Med"
    },
    {
      "key": "b31",
      "doi-asserted-by": "crossref",
      "first-page": "1595",
      "DOI": "10.4049/jimmunol.128.4.1595",
      "volume": "128",
      "author": "Plow EF",
      "year": "1982",
      "journal-title": "J Immunol"
    },
    {
      "key": "b32",
      "first-page": "491",
      "volume-title": "Biological Markers of Neoplasia: Basic and Applied Aspects.",
      "author": "Reich E",
      "year": "1978"
    },
    {
      "key": "b33",
      "first-page": "421",
      "volume-title": "Biological Markers of Neoplasia: Basic and Applied Aspects.",
      "author": "Roblin R",
      "year": "1978"
    },
    {
      "key": "b34",
      "doi-asserted-by": "crossref",
      "first-page": "82",
      "DOI": "10.1016/0167-4838(83)90172-3",
      "volume": "745",
      "author": "Roche PC",
      "year": "1983",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "b35",
      "doi-asserted-by": "crossref",
      "first-page": "669",
      "DOI": "10.1002/ijc.2910300520",
      "volume": "30",
      "author": "Salo T",
      "year": "1982",
      "journal-title": "Int J Cancer"
    },
    {
      "key": "b36",
      "doi-asserted-by": "publisher",
      "DOI": "10.3171/jns.1986.64.2.0263"
    },
    {
      "key": "b37",
      "doi-asserted-by": "crossref",
      "first-page": "361",
      "DOI": "10.1016/0006-8993(81)90138-4",
      "volume": "216",
      "author": "Soreq H",
      "year": "1981",
      "journal-title": "Brain Res"
    },
    {
      "key": "b38",
      "doi-asserted-by": "crossref",
      "first-page": "977",
      "DOI": "10.1007/BF02358887",
      "volume": "31",
      "author": "Tovi D",
      "year": "1975",
      "journal-title": "Experientia"
    },
    {
      "key": "b39",
      "first-page": "297",
      "volume": "38",
      "author": "Tucker WS",
      "year": "1978",
      "journal-title": "Cancer Res"
    },
    {
      "key": "b40",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1084/jem.137.1.85",
      "volume": "137",
      "author": "Unkeless JC",
      "year": "1973",
      "journal-title": "J Exp Med"
    },
    {
      "key": "b41",
      "doi-asserted-by": "crossref",
      "first-page": "575",
      "DOI": "10.1016/S0021-9258(17)37840-7",
      "volume": "254",
      "author": "Vetterlein D",
      "year": "1979",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "b42",
      "first-page": "715",
      "volume": "45",
      "author": "Wainberg MA",
      "year": "1982",
      "journal-title": "Immunology"
    },
    {
      "key": "b43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00006123-198204000-00004"
    },
    {
      "key": "b44",
      "first-page": "933",
      "volume": "40",
      "author": "Wilson EL",
      "year": "1980",
      "journal-title": "Cancer Res"
    },
    {
      "key": "b45",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/B978-0-08-022628-6.50017-8",
      "volume-title": "Regulatory Proteolytic Enzymes and Their Inhibitors.",
      "author": "Wilson EL",
      "year": "1978"
    },
    {
      "key": "b46",
      "first-page": "387",
      "volume": "25",
      "author": "Z\u00e4nker KS",
      "year": "1980",
      "journal-title": "Cell Mol Biol"
    },
    {
      "key": "b47",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0022-510X(78)90246-0"
    }
  ],
  "container-title": "Journal of Neurosurgery",
  "original-title": [],
  "link": [
    {
      "URL": "https://thejns.org/view/journals/j-neurosurg/68/1/article-p73.xml",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://thejns.org/downloadpdf/journals/j-neurosurg/68/1/article-p73.xml",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://thejns.org/downloadpdf/journals/j-neurosurg/68/1/article-p73.xml",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        3,
        13
      ]
    ],
    "date-time": "2024-03-13T06:22:22Z",
    "timestamp": 1710310942000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://thejns.org/view/journals/j-neurosurg/68/1/article-p73.xml"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1988,
        1
      ]
    ]
  },
  "references-count": 47,
  "journal-issue": {
    "issue": "1"
  },
  "URL": "http://dx.doi.org/10.3171/jns.1988.68.1.0073",
  "relation": {},
  "ISSN": [
    "0022-3085"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1988,
        1
      ]
    ]
  }
}