DOI: 10.3171/jns.1985.63.6.0890. Assessment of intracranial hemodynamics in carotid artery disease by transcranial Doppler ultrasound

Assessment of intracranial hemodynamics in carotid artery disease by transcranial Doppler ultrasound

10.3171/jns.1985.63.6.0890

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ Noninvasive transcranial Doppler recordings were correlated to the angiographic findings in 77 patients with carotid artery disease. Stenoses reducing the luminal area of the internal carotid artery by 75% or more also reduced the pulsatility transmission index (PTI) of the ipsilateral middle cerebral artery (MCA). The PTI is the pulsatility index of the artery under study expressed as a percent of the pulsatility index of another intracranial artery with presumed unimpeded inflow in the same individual. For stenoses in the 75% to 89% category, PTI reduction was significantly greater in patients with bilateral carotid stenosis, indicating an impaired potential for collateral flow in these patients. The PTI reduction probably reflects both the pressure drop across the stenosis and the cerebral autoregulatory response. Two criteria proved useful in demonstrating collateral MCA supply through the circle of Willis. On the recipient side, retrograde flow in the proximal anterior cerebral artery was demonstrated in 29 of the 31 patients when this flow pattern was disclosed angiographically. In 26 of these patients, the anterior cerebral artery on the supplying side also had clearly increased flow velocity. Increased flow velocities in the proximal posterior cerebral artery were present in 26 of the 30 vessels that were acting as a collateral channel to the ipsilateral MCA.

Bibliography

Lindegaard, K.-F., Bakke, S. J., Grolimund, P., Aaslid, R., Huber, P., & Nornes, H. (1985). Assessment of intracranial hemodynamics in carotid artery disease by transcranial Doppler ultrasound. Journal of Neurosurgery, 63(6), 890â898.

Authors 6

Karl-Fredrik Lindegaard (first)
Søren Jacob Bakke (additional)
Peter Grolimund (additional)
Rune Aaslid (additional)
Peter Huber (additional)
Helge Nornes (additional)

References 25 Referenced 193

10.3171/jns.1984.60.1.0037 / J Neurosurg / Evaluation of cerebrovascular spasm with transcranial Doppler ultrasound. by Aaslid (1984)
10.3171/jns.1982.57.6.0769 / J Neurosurg / Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. by Aaslid (1982)
{'key': 'b3', 'series-title': 'Surgery', 'first-page': '67', 'article-title': 'Critical stenosis of the internal carotid artery.', 'volume': '89', 'author': 'Archie', 'year': '1981'} / Surgery / Critical stenosis of the internal carotid artery. by Archie (1981)
10.1227/00006123-198207010-00001 / Neurosurgery / Correlation of clinical and angiographic findings in brain ischemia with regional cerebral blood flow measured by the xenon inhalation technique. by Awad (1982)
{'key': 'b5', 'series-title': 'IEEE Trans Sonics Ultrasonics', 'first-page': '170', 'article-title': 'Pulsed ultrasonic Doppler blood-flow sensing.', 'volume': 'SU-17', 'author': 'Baker', 'year': '1970'} / IEEE Trans Sonics Ultrasonics / Pulsed ultrasonic Doppler blood-flow sensing. by Baker (1970)
10.1177/153857447200600103 / Vasc Surg / Cerebral blood flow before and after carotid endarterectomy. by Engell (1972)
10.1161/01.RES.46.4.470 / Circ Res / The relationship between ultrasonic pulsatility index and proximal arterial stenosis in a canine model. by Evans (1980)
10.1177/028418517001000101 / Acta Radiol (Diagn) / Normal size of the internal carotid, middle cerebral and anterior cerebral arteries. by Gabrielsen (1970)
{'key': 'b9', 'series-title': 'Proc R Soc Med', 'first-page': '447', 'article-title': 'Arterial assessment by Dopplershift ultrasound.', 'volume': '67', 'author': 'Gosling', 'year': '1974'} / Proc R Soc Med / Arterial assessment by Dopplershift ultrasound. by Gosling (1974)
10.1001/jama.1968.03140110053011 / JAMA / Joint study of extracranial arterial occlusion. II. Arteriography, techniques, sites, and complications. by Hass (1968)
10.1016/0301-5629(83)90061-3 / Ultrasound Med Biol / Relationship between Doppler pulsatility index and direct femoral pressure measurements in the diagnosis of aortoiliac occlusive disease. by Johnston (1983)
10.1016/0301-5629(84)90196-0 / Ultrasound Med Biol / Pulsed Doppler techniques for measuring instantaneous maximum and mean flow velocities in carotid arteries. by Lindegaard (1984)
10.1038/jcbfm.1984.54 / J Cereb Blood Flow Metab / Dependency of blood flow velocity in the middle cerebral artery on end-tidal carbon dioxide partial pressure. A transcranial ultrasound Doppler study. by Markwalder (1984)
{'key': 'b14', 'series-title': 'Surgery', 'first-page': '513', 'article-title': 'Hemodynamic effects of arterial stenosis.', 'volume': '53', 'author': 'May', 'year': '1963'} / Surgery / Hemodynamic effects of arterial stenosis. by May (1963)
10.1007/BF01432228 / Acta Neurochir / The role of the circle of Willis in graded occlusion of the internal carotid artery in man. by Nornes (1973)
10.3171/jns.1977.47.6.0819 / J Neurosurg / Cerebral arterial blood flow and aneurysm surgery. Part 2: Induced hypotension and autoregulatory capacity. by Nornes (1977)
{'key': 'b17', 'series-title': "L'Onde Electr", 'first-page': '369', 'article-title': 'Vélocimètre sanguin par effet Doppler à émission ultrasonore pulsée.', 'volume': '50', 'author': 'Peronneau', 'year': '1970'} / L'Onde Electr / Vélocimètre sanguin par effet Doppler à émission ultrasonore pulsée. by Peronneau (1970)
10.1056/NEJM197810262991705 / N Engl J Med / Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. by Ransohoff (1978)
10.1001/archneur.1963.00460010024002 / Arch Neurol / Variation in form of circle of Willis. The relation of the variations to collateral circulation: anatomic analysis. by Riggs (1963)
10.1177/153857446700100301 / Vasc Surg / Intraluminal diameters of the intracranial arteries. by Ring (1967)
10.1161/01.STR.10.3.326 / Stroke / Quantitation of carotid stenosis with continuous-wave (C-W) Doppler ultrasound. by Spencer (1979)
10.1161/01.STR.14.4.552 / Stroke / Middle cerebral artery perfusion pressure in cerebrovascular occlusive disease. by Spetzler (1983)
10.1007/BF01401180 / Acta Neurochir / Effects of carotid endarterectomy on blood flow in the internal carotid artery. by Wiberg (1983)
10.1161/01.STR.15.5.816 / Stroke / Cerebral blood flow measurements in cerebrovascular occlusive diseases. by Yanagihara (1984)
10.1161/01.RES.36.6.735 / Circ Res / Pressure drop across artificially induced stenoses in the femoral arteries of dogs. by Young (1975)

Dates

Type	When
Created	16 years, 3 months ago (May 8, 2009, 12:21 p.m.)
Deposited	3 years, 1 month ago (July 24, 2022, 1:41 p.m.)
Indexed	6 days, 16 hours ago (Aug. 24, 2025, 6:56 p.m.)
Issued	39 years, 8 months ago (Dec. 1, 1985)
Published	39 years, 8 months ago (Dec. 1, 1985)
Published Print	39 years, 8 months ago (Dec. 1, 1985)

Funders 0

None

BibTeX

@article{Lindegaard_1985, title={Assessment of intracranial hemodynamics in carotid artery disease by transcranial Doppler ultrasound}, volume={63}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1985.63.6.0890}, DOI={10.3171/jns.1985.63.6.0890}, number={6}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Lindegaard, Karl-Fredrik and Bakke, Søren Jacob and Grolimund, Peter and Aaslid, Rune and Huber, Peter and Nornes, Helge}, year={1985}, month=dec, pages={890–898} }

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