DOI: 10.3171/jns.1985.62.6.0865. Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury

Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury

10.3171/jns.1985.62.6.0865

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ A leukotriene-like immunoreactivity was measured by radioimmunoassay in the gerbil forebrain following ischemia and reperfusion, subarachnoid hemorrhage (SAH), or nonlethal concussive brain injury. In each paradigm an increase in immunoreactivity levels was found. Peak levels were reached 15 to 30 minutes after each insult, and slowly returned to baseline over the next 24 hours. The study supports the suggestion that cerebral vessels and circulating blood are capable of producing leukotrienes, and that a major source of production is a nonvascular component within gray matter, possibly the cortical neuron. Leukotrienes may play a role in the pathophysiology of cerebral edema formation, cerebral vasospasm, seizure activity, and other central nervous system abnormalities. These studies are the first to demonstrate leukotriene production in gerbil brain following SAH or concussive brain injury.

Bibliography

Kiwak, K. J., Moskowitz, M. A., & Levine, L. (1985). Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury. Journal of Neurosurgery, 62(6), 865â869.

Authors 3

Kevin J. Kiwak (first)
Michael A. Moskowitz (additional)
Lawrence Levine (additional)

References 42 Referenced 132

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Dates

Type	When
Created	16 years, 3 months ago (May 8, 2009, 12:20 p.m.)
Deposited	3 years, 1 month ago (July 24, 2022, 3:03 p.m.)
Indexed	2 months, 3 weeks ago (June 11, 2025, 5:29 a.m.)
Issued	40 years, 3 months ago (June 1, 1985)
Published	40 years, 3 months ago (June 1, 1985)
Published Print	40 years, 3 months ago (June 1, 1985)

Funders 0

None

BibTeX

@article{Kiwak_1985, title={Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury}, volume={62}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1985.62.6.0865}, DOI={10.3171/jns.1985.62.6.0865}, number={6}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Kiwak, Kevin J. and Moskowitz, Michael A. and Levine, Lawrence}, year={1985}, month=jun, pages={865–869} }

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