Embryonal central neuroepithelial tumors and their differentiating potential
10.3171/jns.1985.62.6.0795
Crossref journal-article
Journal of Neurosurgery Publishing Group (JNSPG)
Journal of Neurosurgery (1754)
Abstract

✓ The embryonal central nervous system (CNS) neoplasms are reviewed with special reference to their differentiating potential and in the light of current neuro-oncogenetic concepts partly derived from the experimental induction of neural tumors. The conceptual (and, occasionally, practical) distinction between adult-type and embryonal CNS tumors raises a complex problem, because neoplastic transformation essentially involves replicating stem cells in tissues of renewal and because in the human brain such cells are found mostly in the course of CNS development. A cytogenetic scheme is therefore needed to serve as a frame of reference for a classification of embryonal CNS tumors that will account for the different histological entities documented so far and for the range and the restrictions of their differentiating capabilities. Most embryonal CNS tumors can be fitted into such a scheme. The cerebral medulloepithelioma, the cerebral and cerebellar neuroblastomas, the primitive polar spongioblastoma, and the ependymoblastoma show characteristic morphological features and a correspondingly distinctive cellular differentiating potential. The differentiating capabilities of the cerebellar medulloblastoma, the pineoblastoma, and the retinoblastoma are also distinctive, and are apparently determined by the cytogenesis of the area of the CNS in which the tumors originate. The indiscriminate application of a simplistic concept that would include all the so-called “primitive neuroectodermal tumors” into a single neuroepithelial tumor entity is unlikely to bring further understanding to the problem.

Bibliography

Rubinstein, L. J. (1985). Embryonal central neuroepithelial tumors and their differentiating potential. Journal of Neurosurgery, 62(6), 795–805.

Authors 1
  1. Lucien J. Rubinstein (first)
References 100 Referenced 130
  1. 10.1097/00005072-198305000-00004 / J Neuropathol Exp Neurol / Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light microscopic and immunohistochemical study. by Auer (1983)
  2. 10.1097/00005072-197703000-00013 / J Neuropathol Exp Neurol / Central neuroblastoma. Electron microscopic observations and catecholamine determinations. by Azzarelli (1977)
  3. 10.1136/jnnp.43.11.1041 / J Neurol Neurosurg Psychiatry / Astrocytic differentiation in medulloblastoma. by Barnard (1980)
  4. 10.1016/S0046-8177(83)80006-9 / Hum Pathol / Primitive neuroectodermal tumors of the central nervous system. by Becker (1983)
  5. 10.1002/ana.410160106 / Ann Neurol / The biological behavior of primary cerebral neuroblastoma: a reappraisal of the clinical course in a series of 70 cases. by Bennett (1984)
  6. 10.3171/jns.1983.59.3.0418 / J Neurosurg / Primary cerebral neuroblastoma. Long-term follow-up review and therapeutic guidelines. by Berger (1983)
  7. 10.1055/s-2008-1063895 / Semin Neurol / A proposed basis for the therapeutic resistance of gliomas. by Bigner (1981)
  8. {'key': 'b8', 'series-title': 'J Natl Cancer Inst', 'first-page': '95', 'article-title': 'Routine growth and differentiation of primary retinoblastoma cells in culture.', 'volume': '70', 'author': 'Bogenmann', 'year': '1983'} / J Natl Cancer Inst / Routine growth and differentiation of primary retinoblastoma cells in culture. by Bogenmann (1983)
  9. 10.1002/ar.1091660214 / Anat Rec / Embryonic vertebrate central nervous system: revised terminology. by The Boulder Committee: (1970)
  10. 10.1002/jcp.1040880302 / J Cell Physiol / Development of a clonal myogenic cell line with unusual biochemical properties. by Brandt (1976)
  11. {'key': 'b11', 'series-title': 'Neurosurgery', 'first-page': '398', 'article-title': 'Medulloblastoma: an ultrastructural study — evidence for astrocytic and neuronal differentiation.', 'volume': '6', 'author': 'Camins', 'year': '1980'} / Neurosurgery / Medulloblastoma: an ultrastructural study — evidence for astrocytic and neuronal differentiation. by Camins (1980)
  12. 10.1126/science.6197755 / Science / Expression of glial fibrillary acidic protein in immature oligodendroglia. by Choi (1984)
  13. 10.1016/0165-3806(83)90163-3 / Dev Brain Res / Do radial glia give rise to both astroglial and oligodendroglial cells? by Choi (1983)
  14. 10.1016/0006-8993(78)90721-7 / Brain Res / Radial glia in the human fetal cerebrum: a combined Golgi, immunofluorescent and electron microscopic study. by Choi (1978)
  15. {'key': 'b15', 'series-title': 'Bull Cancer (Paris)', 'first-page': '301', 'article-title': "Ultrastructure d'une tumeur de la rétine.", 'volume': '59', 'author': 'Choux', 'year': '1972'} / Bull Cancer (Paris) / Ultrastructure d'une tumeur de la rétine. by Choux (1972)
  16. 10.1016/0006-8993(76)90397-8 / Brain Res / Differentiation of Bergmann glial cells in the cerebellum: a Golgi study. by Das (1976)
  17. 10.1016/0006-8993(74)90366-7 / Brain Res / Contact guidance and migratory cells in the developing cerebellum. by Das (1974)
  18. 10.1136/jnnp.45.2.139 / J Neurol Neurosurg Psychiatry / Cerebral ganglioglio-neuroblastoma: an unusual brain tumour of the neuron series. by Dastur (1982)
  19. 10.1007/BF00690355 / Acta Neuropathol / The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. by Deck (1978)
  20. 10.1136/bjo.60.5.371 / Br J Ophthalmol / Synapse formation in retinoblastoma tumours. by Dickson (1976)
  21. 10.1177/26.7.357640 / J Histochem Cytochem / Contribution of immunohistochemistry to diagnostic problems of human cerebral tumors. by Eng (1978)
  22. {'key': 'b22', 'series-title': 'Acta Neurol Belg', 'first-page': '208', 'article-title': 'Arguments ultrastructuraux en faveur de Tappartenance du médulloblastome à la lignée neuronale.', 'volume': '74', 'author': 'Ermel', 'year': '1974'} / Acta Neurol Belg / Arguments ultrastructuraux en faveur de Tappartenance du médulloblastome à la lignée neuronale. by Ermel (1974)
  23. {'key': 'b23', 'series-title': 'J Neuro-oncol', 'first-page': '95', 'article-title': 'Extensive advanced maturation of medulloblastoma to astrocytoma and ependymoma.', 'volume': '1', 'author': 'Feigin', 'year': '1983'} / J Neuro-oncol / Extensive advanced maturation of medulloblastoma to astrocytoma and ependymoma. by Feigin (1983)
  24. 10.1002/cne.901200104 / J Comp Neurol / The matrix cell and cytogenesis in the developing central nervous system. by Fujita (1963)
  25. 10.1083/jcb.32.2.277 / J Cell Biol / Quantitative analysis of cell proliferation and differentiation in the cortex of the postnatal mouse cerebellum. by Fujita (1967)
  26. 10.1002/cne.901280206 / J Comp Neurol / H3-thymidine autoradiographic studies on the cell proliferation and differentiation in the external and internal granular layers of the mouse cerebellum. by Fujita (1966)
  27. 10.1002/1097-0142(19820401)49:7<1420::AID-CNCR2820490719>3.0.CO;2-6 / Cancer / Complex cerebral tumor with evidence of neuronal, glial and Schwann cell differentiation: a histologic, immunocytochemical and ultrastructural study. by Gambarelli (1982)
  28. 10.1002/1097-0142(197310)32:4<890::AID-CNCR2820320421>3.0.CO;2-O / Cancer / Primitive neuroectodermal tumors of the brain in children. by Hart (1973)
  29. {'key': 'b29', 'series-title': 'Acta Neuropathol', 'first-page': '151', 'article-title': 'Central neurocytoma. An electron-microscopic study of two cases.', 'volume': '56', 'author': 'Hassoun', 'year': '1982'} / Acta Neuropathol / Central neurocytoma. An electron-microscopic study of two cases. by Hassoun (1982)
  30. 10.1007/BF00684917 / Acta Neuropathol / Specific ultrastructural markers of human pinealomas. A study of four cases. by Hassoun (1983)
  31. 10.1007/BF00689823 / Acta Neuropathol / Divergent glial and neuronal differentiation in a cerebellar medulloblastoma in an organ culture system: in vitro occurrence of synaptic ribbons. by Herman (1984)
  32. {'key': 'b32', 'series-title': 'Am J Pathol', 'first-page': '421', 'article-title': 'An experimental mouse testicular teratoma as a model for neuroepithelial neoplasia and differentiation. II. Electron microscopy.', 'volume': '81', 'author': 'Herman', 'year': '1975'} / Am J Pathol / An experimental mouse testicular teratoma as a model for neuroepithelial neoplasia and differentiation. II. Electron microscopy. by Herman (1975)
  33. 10.1093/brain/102.2.289 / Brain / The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). A clinicopathologic study of 28 tumours. by Herrick (1979)
  34. 10.1111/j.1365-2990.1979.tb00614.x / Neuropathol Appl Neurobiol / Unattached presynaptic terminals in a cerebellar neuroblastoma in the human. by Hirano (1979)
  35. 10.1093/brain/99.4.735 / Brain / Primary cerebral neuroblastoma. A clinicopathological study of 35 cases. by Horten (1976)
  36. {'key': 'b36', 'series-title': 'Tumours of the Brain and Skull, Part II. Handbook of Clinical Neurology', 'first-page': '1', 'article-title': 'Experimental brain tumours', 'volume': '17', 'author': 'Jänisch', 'year': '1974'} / Tumours of the Brain and Skull, Part II. Handbook of Clinical Neurology / Experimental brain tumours by Jänisch (1974)
  37. {'key': 'b37', 'series-title': 'Tumoren des Zentralnervensystems bei Feten und Säuglingen. Häufigkeit, Pathogenese, Pathomorphologie, Krankheitsverläufe.', 'author': 'Jänisch', 'year': '1980'} / Tumoren des Zentralnervensystems bei Feten und Säuglingen. Häufigkeit, Pathogenese, Pathomorphologie, Krankheitsverläufe. by Jänisch (1980)
  38. 10.1097/00005072-197010000-00005 / J Neuropathol Exp Neurol / Neonatal cerebellar medulloblastoma originating from the fetal external granular layer. by Kadin (1970)
  39. 10.1002/1097-0142(197911)44:5<1692::AID-CNCR2820440524>3.0.CO;2-K / Cancer / Pineoblastoma: an electron microscopic study. by Kline (1979)
  40. 10.3171/jns.1978.48.5.0741 / J Neurosurg / Primitive neuroectodermal tumors of the central nervous system in children. by Kosnik (1978)
  41. 10.1038/281586a0 / Nature / Neurectoderm markers retained in phenotypical skeletal muscle cells arising from a glial cell line. by Lennon (1979)
  42. 10.1523/JNEUROSCI.01-01-00027.1981 / J Neurosci / Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. by Levitt (1981)
  43. 10.1016/0012-1606(83)90184-7 / Dev Biol / Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone. by Levitt (1983)
  44. 10.1002/cne.901930316 / J Comp Neurol / Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. by Levitt (1980)
  45. 10.1055/s-2008-1063896 / Semin Neurol / Cell proliferation in the postnatal nervous system and its relationship to the origin of gliomas. by Lewis (1981)
  46. 10.1111/j.1365-2990.1977.tb00582.x / Neuropathol Appl Neurobiol / Neuroglia in the internal granular layer of the developing rat cerebellar cortex. by Lewis (1977)
  47. {'key': 'b47', 'series-title': 'Neuroectodermal Tumors of the Central and Peripheral Nervous System.', 'first-page': '183', 'article-title': 'Glial and parenchymal neoplasms in tissue culture', 'author': 'Liss', 'year': '1969'} / Neuroectodermal Tumors of the Central and Peripheral Nervous System. / Glial and parenchymal neoplasms in tissue culture by Liss (1969)
  48. 10.1007/BF00692223 / Acta Neuropathol / Congenital ependymoblastoma. by Lorentzen (1980)
  49. 10.1038/308274a0 / Nature / Proliferation of mature oligodendrocytes after trauma to the central nervous system. by Ludwin (1984)
  50. {'key': 'b50', 'series-title': 'Pathology of Tumours of the Nervous System', 'first-page': '334', 'article-title': 'The study by tissue culture of tumours of the nervous system', 'author': 'Lumsden', 'year': '1971'} / Pathology of Tumours of the Nervous System / The study by tissue culture of tumours of the nervous system by Lumsden (1971)
  51. {'key': 'b51', 'series-title': 'Tumours of the Brain and Skull, Part II. Handbook of Clinical Neurology', 'first-page': '42', 'article-title': 'Tissue culture of brain tumours', 'volume': '17', 'author': 'Lumsden', 'year': '1974'} / Tumours of the Brain and Skull, Part II. Handbook of Clinical Neurology / Tissue culture of brain tumours by Lumsden (1974)
  52. 10.1007/BF00691533 / Acta Neuropathol / Glial fibrillary acidic protein in medulloblastoma. by Mannoji (1981)
  53. 10.1002/1097-0142(197907)44:1<141::AID-CNCR2820440125>3.0.CO;2-T / Cancer / Electron microscopic findings in primitive neuroectodermal tumors of the cerebrum. by Markesbery (1979)
  54. 10.1007/BF00699239 / Acta Neuropathol / Ultrastructure of pineal parenchymal neoplasms. by Markesbery (1981)
  55. 10.1097/00005072-198001000-00003 / J Neuropathol Exp Neurol / Ultrastructural study of the medulloblastoma in tissue culture. by Markesbery (1980)
  56. 10.1016/0012-1606(83)90177-X / Dev Biol / Neuronal cell-surface specific antigen(s) is expressed during the terminal mitosis of cells destined to become neuroblasts. by Masuko (1983)
  57. 10.1002/1097-0142(19850401)55:7<1536::AID-CNCR2820550721>3.0.CO;2-A / Cancer / Ependymoblastoma. A reappraisal of a rare embryonal tumor. by Mörk (1985)
  58. 10.1111/j.1365-2559.1983.tb02306.x / Histopathology / Evidence for differentiation in medulloblastomas appearing primitive on light microscopy: an ultrastructural study. by Moss (1983)
  59. 10.1007/BF00685322 / Acta Neuropathol / Beitrag zur morphologischen Onkotypie des Medulloblastoms. by Müller (1974)
  60. {'key': 'b60', 'series-title': 'Cerebellar Cortex. Cytology and Organization.', 'first-page': '290', 'author': 'Palay', 'year': '1974'} / Cerebellar Cortex. Cytology and Organization. by Palay (1974)
  61. 10.3171/jns.1981.55.2.0161 / J Neurosurg / Differentiation of medulloblastoma. Studies including immunohistochemical localization of glial fibrillary acidic protein. by Palmer (1981)
  62. {'key': 'b62', 'series-title': 'Ann Pathol', 'first-page': '203', 'article-title': "Protéine gliofibrillaire acide (GFA) et tumeurs nerveuses centrales. Etude immunohistochimique d'une série de 207 cas. IIe partie: Médulloblastomes. Hémangioblastomes. Autres tumeurs. Discussion.", 'volume': '3', 'author': 'Pasquier', 'year': '1983'} / Ann Pathol / Protéine gliofibrillaire acide (GFA) et tumeurs nerveuses centrales. Etude immunohistochimique d'une série de 207 cas. IIe partie: Médulloblastomes. Hémangioblastomes. Autres tumeurs. Discussion. by Pasquier (1983)
  63. 10.1002/1097-0142(19810215)47:4<772::AID-CNCR2820470423>3.0.CO;2-E / Cancer / Cerebellar “neuroblastoma.” Nosology as it relates to medulloblastoma. by Pearl (1981)
  64. {'key': 'b64', 'series-title': 'Cancer: A Problem of Developmental Biology.', 'first-page': '68', 'author': 'Pierce', 'year': '1978'} / Cancer: A Problem of Developmental Biology. by Pierce (1978)
  65. 10.1016/S0022-5320(69)90072-0 / J Ultrastruct Res / The fine structure of nuclear alterations in retinoblastoma and in the developing human retina: in vivo and in vitro observations. by Popoff (1969)
  66. {'key': 'b66', 'series-title': 'Lab Invest', 'first-page': '389', 'article-title': 'The fine structure of retinoblastoma. In vivo and in vitro observations.', 'volume': '25', 'author': 'Popoff', 'year': '1971'} / Lab Invest / The fine structure of retinoblastoma. In vivo and in vitro observations. by Popoff (1971)
  67. 10.1002/path.1711150404 / J Pathol / An ependymoblastoma of the pons. by Queiroz (1975)
  68. 10.1001/archneurpsyc.1944.02290330002001 / Arch Neurol Psychiatry / Relation of abnormal collections of cells in posterior medullary velum of cerebellum to origin of medulloblastoma. by Raaf (1944)
  69. 10.1097/00005072-198303000-00001 / J Neuropathol Exp Neurol / Neuronal and astrocytic differentiation in human neuroepithelial neoplasms. An immunohistochemical study. by Roessmann (1983)
  70. 10.1097/00005072-198301000-00001 / J Neuropathol Exp Neurol / The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. by Rorke (1983)
  71. {'key': 'b71', 'series-title': 'Tumours of the Brain and Skull, Part II. Handbook of Clinical Neurology', 'first-page': '167', 'article-title': 'The cerebellar medulloblastoma: its origin, differentiation, morphological variants, and biological behavior', 'volume': '18', 'author': 'Rubinstein', 'year': '1975'} / Tumours of the Brain and Skull, Part II. Handbook of Clinical Neurology / The cerebellar medulloblastoma: its origin, differentiation, morphological variants, and biological behavior by Rubinstein (1975)
  72. 10.1097/00005072-197201000-00002 / J Neuropathol Exp Neurol / Cytogenesis and differentiation of primitive central neuroepithelial tumors. by Rubinstein (1972)
  73. {'key': 'b73', 'series-title': 'Arch Pathol', 'first-page': '35', 'article-title': 'The definition of the ependymoblastoma.', 'volume': '90', 'author': 'Rubinstein', 'year': '1970'} / Arch Pathol / The definition of the ependymoblastoma. by Rubinstein (1970)
  74. {'key': 'b74', 'series-title': 'Recent Advances in Neuropathology.', 'first-page': '179', 'article-title': 'Recent advances in human neuro-oncology', 'author': 'Rubinstein', 'year': '1979'} / Recent Advances in Neuropathology. / Recent advances in human neuro-oncology by Rubinstein (1979)
  75. 10.1002/1097-0142(197403)33:3<675::AID-CNCR2820330312>3.0.CO;2-E / Cancer / The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Light, electron microscopic, tissue, and organ culture observations. by Rubinstein (1974)
  76. {'key': 'b76', 'series-title': 'Pathology of Tumours of the Nervous System', 'first-page': '193', 'author': 'Russell', 'year': '1977'} / Pathology of Tumours of the Nervous System by Russell (1977)
  77. 10.1007/BF00692865 / Acta Neuropathol / Congenital cerebellar neuroepithelial tumor with multiple divergent differentiations. by Sato (1980)
  78. {'key': 'b78', 'series-title': 'Childs Brain', 'first-page': '62', 'article-title': 'Cerebral medulloblastoma. Report of a case with multiple divergent neuroepithelial differentiation.', 'volume': '5', 'author': 'Scheithauer', 'year': '1979'} / Childs Brain / Cerebral medulloblastoma. Report of a case with multiple divergent neuroepithelial differentiation. by Scheithauer (1979)
  79. 10.1016/S0344-0338(83)80021-1 / Pathol Res Pract / Rapid anaplastic transformation in gliomas of adulthood. “Selection” in neuro-oncogenesis. by Schmitt (1983)
  80. 10.1055/s-2008-1059566 / Neuropediatrics / Rapid anaplastic transformation of gliomas in childhood. by Schmitt (1983)
  81. 10.1007/BF01273260 / Acta Neuropathol / Fine structure of a cerebellar neuroblastoma. by Shin (1978)
  82. 10.1007/BF00691324 / Acta Neuropathol / Pineoblastoma with ganglionic and glial differentiation. Report of two cases. by Sobel (1981)
  83. 10.1093/brain/102.2.321 / Brain / Pinealoblastoma with retinoblastomatous differentiation. by Stefanko (1979)
  84. 10.1038/bjc.1973.187 / Br J Cancer / Group characteristics of children with cerebral and spinal cord tumours. by Stewart (1973)
  85. 10.1007/BF01261508 / J Neurocytol / Lack of evidence for glial cells originating from the external granular layer in mouse cerebellum. by Swarz (1977)
  86. 10.1038/292836a0 / Nature / Neuronal precursor cells in the chick neural tube express neurofilament proteins. by Tapscott (1981)
  87. 10.1136/bjo.63.8.551 / Br J Ophthalmol / A scanning electron microscopic examination of retinoblastoma in tissue culture. by Taylor (1979)
  88. 10.1016/0002-9394(70)92264-6 / Am J Ophthalmol / The nature of retinoblastoma. II. Photoreceptor differentiation: an electron microscopic study. by Ts'o (1970)
  89. 10.1016/0002-9394(70)92263-4 / Am J Ophthalmol / The nature of retinoblastoma. I. Photoreceptor differentiation: a clinical and histopathologic study. by Ts'o (1970)
  90. {'key': 'b90', 'series-title': 'Acta Neuropathol', 'first-page': '243', 'article-title': 'Experimental pineocytoma of the Syrian hamster induced by a human papovavirus (JC). A light and electron microscopic study.', 'volume': '35', 'author': 'Varakis', 'year': '1976'} / Acta Neuropathol / Experimental pineocytoma of the Syrian hamster induced by a human papovavirus (JC). A light and electron microscopic study. by Varakis (1976)
  91. 10.1002/1097-0142(19800201)45:3<484::AID-CNCR2820450312>3.0.CO;2-9 / Cancer / Immunohistochemical localization of glial fibrillary acidic protein in human glial neoplasms. by Velasco (1980)
  92. 10.1007/BF00165721 / J Neuro-oncol / Morphology and biology of cerebellar neuroblastomas. by Warzok (1983)
  93. {'key': 'b93', 'series-title': 'Evolution of the Forebrain.', 'first-page': '213', 'article-title': 'Electron-microscopy of the cytodifferentiation in the developing brain of chick embryos', 'author': 'Wechsler', 'year': '1966'} / Evolution of the Forebrain. / Electron-microscopy of the cytodifferentiation in the developing brain of chick embryos by Wechsler (1966)
  94. 10.1002/1097-0142(197709)40:3<1087::AID-CNCR2820400317>3.0.CO;2-N / Cancer / Characterization and radiobiologic parameters of medulloblastoma in vitro. by Weichselbaum (1977)
  95. {'key': 'b95', 'series-title': 'The Borderland of Embryology and Pathology.', 'first-page': '410', 'author': 'Willis', 'year': '1958'} / The Borderland of Embryology and Pathology. by Willis (1958)
  96. 10.1007/BF00692864 / Acta Neuropathol / Cerebellar neuroblastoma. A light and ultrastructural study. by Yagishita (1980)
  97. 10.1007/BF00691178 / Acta Neuropathol / Morphological investigations on cerebellar “neuroblastoma” group. by Yagishita (1982)
  98. 10.1111/j.1749-6632.1969.tb48290.x / Ann NY Acad Sci / Brain tumors: their incidence and classification in man and their experimental production. by Zimmerman (1969)
  99. {'key': 'b99', 'series-title': 'Histological Typing of Tumours of the Central Nervous System.', 'first-page': '48', 'author': 'Zülch', 'year': '1979'} / Histological Typing of Tumours of the Central Nervous System. by Zülch (1979)
  100. {'key': 'b100', 'series-title': 'Natl Cancer Inst Monogr', 'first-page': '205', 'article-title': 'Perinatal induction of medulloblastomas in Syrian hamsters by a human polyoma virus (JC).', 'volume': '51', 'author': 'Zu Rhein', 'year': '1979'} / Natl Cancer Inst Monogr / Perinatal induction of medulloblastomas in Syrian hamsters by a human polyoma virus (JC). by Zu Rhein (1979)
Dates
Type When
Created 16 years, 3 months ago (May 8, 2009, 12:20 p.m.)
Deposited 3 years, 1 month ago (July 24, 2022, 3:02 p.m.)
Indexed 11 months, 1 week ago (Sept. 15, 2024, 1:48 p.m.)
Issued 40 years, 2 months ago (June 1, 1985)
Published 40 years, 2 months ago (June 1, 1985)
Published Print 40 years, 2 months ago (June 1, 1985)
Funders 0

None

@article{Rubinstein_1985, title={Embryonal central neuroepithelial tumors and their differentiating potential: A cytogenetic view of a complex neuro-oncological problem}, volume={62}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1985.62.6.0795}, DOI={10.3171/jns.1985.62.6.0795}, number={6}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Rubinstein, Lucien J.}, year={1985}, month=jun, pages={795–805} }