DOI: 10.3171/jns.1975.43.3.0323. Experimental cerebral oligemia and ischemia produced by intracranial hypertension

Experimental cerebral oligemia and ischemia produced by intracranial hypertension

10.3171/jns.1975.43.3.0323

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ The authors studied the effect on cortical metabolites of intracranial hypertension produced by the infusion of mock cerebrospinal fluid into the cisterna magna in rabbits subjected to 15 minutes of cerebral oligemia (20 torr) or 15 minutes of complete ischemia. In both groups high-energy metabolites were exhausted within the first 5 minutes of the 15-minute insult. Significant recovery of the high-energy intermediates occurred within 15 minutes of reperfusion, well before return of electroencephalogram (EEG) activity. Continued reperfusion, during which electrical activity and function were returning, brought only moderate improvement in energy metabolites. In contrast, severe lactic acidosis persisted at least 15 minutes after insult, but was reduced by the time EEG activity returned. At no time were there striking differences in metabolites between the oligemic and ischemic groups. These results indicate that recovery in general, and the significantly earlier recovery of oligemic as compared to ischemic animals, cannot be explained on the basis of energy supply. Whether the persistence of lactic acidosis is an important factor limiting return of function requires further study.

Bibliography

Marshall, L. F., Welsh, F., Durity, F., Lounsbury, R., Graham, D. I., & Langfitt, T. W. (1975). Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Journal of Neurosurgery, 43(3), 323â328.

Authors 6

Lawrence F. Marshall (first)
Frank Welsh (additional)
Felix Durity (additional)
Robert Lounsbury (additional)
David I. Graham (additional)
Thomas W. Langfitt (additional)

References 13 Referenced 70

10.1007/BF00689000 / Acta Neuropathol / The earliest alterations in rat neurons and astrocytes after anoxia-ischemia. by Brown (1973)
10.1111/j.1471-4159.1972.tb01417.x / J Neurochem / Cerebral carbohydrate metabolism during acute hypoxia and recovery. by Duffy (1972)
10.1001/archneur.1973.00490300037004 / Arch Neurol / Reversibility of ischemic brain damage. by Hossman (1973)
10.1016/0026-0495(71)90087-4 / Metabolism / Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria. by LaNoue (1971)
{'key': 'b5', 'series-title': 'Monamine metabolism in rat brain after increased pressure.', 'author': 'Ljunggren'} / Monamine metabolism in rat brain after increased pressure. by Ljunggren
{'key': 'b6', 'series-title': 'Intracranial Pressure: Experimental and Clinical Aspects.', 'first-page': '90', 'article-title': 'Energy state of the brain during and after compression ischemia', 'author': 'Ljunggren', 'year': '1972'} / Intracranial Pressure: Experimental and Clinical Aspects. / Energy state of the brain during and after compression ischemia by Ljunggren (1972)
{'key': 'b7', 'series-title': 'Cerebral metabolic state during post-ischemic “recovery”', 'author': 'Ljunggren', 'year': '1973'} / Cerebral metabolic state during post-ischemic “recovery” by Ljunggren (1973)
{'key': 'b8', 'series-title': 'A Flexible System of Enzymatic Analysis.', 'author': 'Lowry', 'year': '1972'} / A Flexible System of Enzymatic Analysis. by Lowry (1972)
10.3171/jns.1975.43.3.0308 / J Neurosurg / Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 1: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier, and neurological function. by Marshall (1975)
10.3171/jns.1975.43.3.0318 / J Neurosurg / Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 2: Brain morphology. by Marshall (1975)
10.1001/archneur.1973.00490300070009 / Arch Neurol / Brain mitochondrial function after ischemic and hypoxia. 1. Ischemia induced by increased intracranial pressure. by Schutz (1973)
{'key': 'b12', 'series-title': 'Exp Brain Res', 'first-page': '81', 'article-title': 'A possible role for gammaaminobutyric acid in the homeostatic control of brain metabolism under conditions of hypoxia.', 'volume': '4', 'author': 'Wood', 'year': '1967'} / Exp Brain Res / A possible role for gammaaminobutyric acid in the homeostatic control of brain metabolism under conditions of hypoxia. by Wood (1967)
10.1111/j.1748-1716.1970.tb04716.x / Acta Physiol Scand / The influence of an increased intracranial pressure on the lactate, pyruvate, bicarbonate, phosphocreatine, ATP, ADP and AMP concentrations of the cerebral cortex of dogs. by Zwetnow (1970)

Dates

Type	When
Created	16 years, 3 months ago (May 7, 2009, 11:04 a.m.)
Deposited	3 years, 1 month ago (July 25, 2022, 3:03 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 12, 2024, 1:48 a.m.)
Issued	50 years ago (Sept. 1, 1975)
Published	50 years ago (Sept. 1, 1975)
Published Print	50 years ago (Sept. 1, 1975)

Funders 0

None

BibTeX

@article{Marshall_1975, title={Experimental cerebral oligemia and ischemia produced by intracranial hypertension: Part 3: Brain energy metabolism}, volume={43}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1975.43.3.0323}, DOI={10.3171/jns.1975.43.3.0323}, number={3}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Marshall, Lawrence F. and Welsh, Frank and Durity, Felix and Lounsbury, Robert and Graham, David I. and Langfitt, Thomas W.}, year={1975}, month=sep, pages={323–328} }

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