DOI: 10.3171/jns.1975.42.2.0155. Vasogenic edema following acute and chronic spinal cord compression in the dog

Vasogenic edema following acute and chronic spinal cord compression in the dog

10.3171/jns.1975.42.2.0155

Crossref journal-article

Journal of Neurosurgery Publishing Group (JNSPG)

Journal of Neurosurgery (1754)

Abstract

✓ The T-13 spinal cord segment of dogs was compressed both acutely and chronically by means of a balloon catheter. The vascular permeability to protein was assessed using Evans blue albumin (EBA), and the dorsal column evoked potential recorded to monitor conduction failure. With acute compression sufficient to cause conduction failure there was a marked leakage of EBA from the intermediate gray matter, which spread into the dorsolateral white matter. The degree of edema was similar whether the compression was maintained or released. Chronic compression maintained over 4 to 5 hours did not increase vascular permeability, but following release of compression leakage of EBA occurred in the same cord locations observed with leakage from acute compressions. This increased permeability following release of chronic compression may result from reactive hyperemia. Dorsal column conduction returned after the release of both acute and chronic compression. The extravasated EBA was present both in the extracellular space and within cells. The results and their clinical application are discussed.

Bibliography

Griffiths, I. R. (1975). Vasogenic edema following acute and chronic spinal cord compression in the dog. Journal of Neurosurgery, 42(2), 155â165.

Authors 1

Ian R. Griffiths (first)

References 33 Referenced 71

10.3171/jns.1964.21.6.0485 / J Neurosurg / Blood pressure responses in acute compression of the spinal cord. by Alexander (1964)
{'key': 'b2', 'series-title': 'J Bone Joint Surg (Am)', 'first-page': '471', 'article-title': 'Experimental traumatic paraplegia. The vascular and pathological changes seen in reversible and irreversible spinal cord lesions.', 'volume': '53', 'author': 'Assenmacher', 'year': '1971'} / J Bone Joint Surg (Am) / Experimental traumatic paraplegia. The vascular and pathological changes seen in reversible and irreversible spinal cord lesions. by Assenmacher (1971)
10.1212/WNL.20.8.802 / Neurology (Minneap) / Regional cerebral blood flow during acute ischemia. Correlation of autoradiographic measurements with observation of cortical microcirculation. by Blair (1970)
10.1097/00005072-196901000-00008 / J Neuropathol Exp Neurol / The fate of escaped plasma protein after thermal necrosis of the rat brain: an electron microscopic study. by Blakemore (1969)
10.3171/jns.1972.37.5.0591 / J Neurosurg / Reversible spinal cord trauma in cats. Additive effects of direct pressure and ischemia. by Brodkey (1972)
10.3171/jns.1973.39.1.0065 / J Neurosurg / Neurophysiological assessment of afferent and efferent conduction in the injured spinal cord of monkeys. by Deecke (1973)
10.3171/jns.1971.35.3.0263 / J Neurosurg / The microvasculature in transitory traumatic paraplegia. An electron microscope study in the monkey. by Dohrmann (1971)
10.3109/10520297109067886 / Stain Technol / Demonstration of the microvasculature of the spinal cord by intravenous injection of the fluorescent dye Thioflavin S. by Dohrmann (1971)
10.3171/jns.1973.38.4.0438 / J Neurosurg / A percutaneous technique for producing intraspinal mass lesions in experimental animals. by Doppman (1973)
10.1212/WNL.18.12.1166 / Neurology (Minneap) / Derangement of regional cerebral blood flow and of its regulatory mechanisms in acute cerebro-vascular lesions. by Fieschi (1968)
10.1152/ajplegacy.1956.185.1.217 / Am J Physiol / Physiology of spinal cord, nerve roots and peripheral nerve compression. by Gelfan (1956)
10.1016/0014-4886(73)90169-6 / Exp Neurol / Demyelination and remyelination after acute spinal cord compression. by Gledhill (1973)
10.1136/vr.87.24.737 / Vet Rec / A syndrome produced by dorsolateral “explosions” of the cervical intervertebral discs. by Griffiths (1970)
10.1016/0022-510X(74)90002-1 / J Neurol Sci / Vascular permeability to protein and vasogenic oedema in experimental concussive injuries to the canine spinal cord. by Griffiths (1974)
10.1111/j.1600-0404.1972.tb07547.x / Acta Neurol Scand / On the pathophysiology of the increased cerebrovascular permeability in acute arterial hypertension in cats. by Haggendal (1972)
10.1007/BF00687666 / Acta Neuropathol (Berl) / The effect of acute arterial hypertension on the blood-brain barrier to protein tracers. by Johansson (1970)
{'key': 'b17', 'series-title': 'Nagoya J Med Sci', 'first-page': '171', 'article-title': 'Experimental study on anterior spinal cord compression with special emphasis on vascular disturbance.', 'volume': '31', 'author': 'Kamiya', 'year': '1967'} / Nagoya J Med Sci / Experimental study on anterior spinal cord compression with special emphasis on vascular disturbance. by Kamiya (1967)
10.1136/jnnp.36.6.898 / J Neurol Neurosurg Psychiatry / Cerebral circulatory and metabolic effects of hypotension produced by deep halothane anesthesia. by Keaney (1973)
{'key': 'b19', 'series-title': 'Brain Edema.', 'first-page': '554', 'article-title': 'Dynamics of cold injury edema', 'author': 'Klatzo', 'year': '1967'} / Brain Edema. / Dynamics of cold injury edema by Klatzo (1967)
10.1007/BF00691750 / Acta Neuropathol (Berl) / Glycogen accumulation in spinal cord motor neurones due to partial ischemia. by Long (1972)
10.1093/brain/93.3.583 / Brain / The effects of experimental demyelination on conduction in the central nervous system. by McDonald (1970)
10.1038/233265a0 / Nature / Nature of the nerve lesion caused by a pneumatic tourniquet. by Ochoa (1971)
10.3171/jns.1958.15.3.0308 / J Neurosurg / The dynamic factor in spinal cord compression. A study on dogs with special reference to cervical disc protrusions. by Olsson (1958)
10.1007/BF00687597 / Acta Neuropathol (Berl) / The blood-brain barrier to protein tracers in focal cerebral ischemia and infarction caused by occlusion of the middle cerebral artery. by Olsson (1971)
10.1007/BF00687665 / Acta Neuropathol (Berl) / Fine structural localisation of exudated protein tracers in the brain. by Olsson (1970)
{'key': 'b26', 'series-title': 'J Neurosurg', 'first-page': '5', 'article-title': 'The pathophysiological response to spinal cord injury. The current status of related research.', 'volume': '40', 'author': 'Osterholm', 'year': '1974'} / J Neurosurg / The pathophysiological response to spinal cord injury. The current status of related research. by Osterholm (1974)
10.3171/jns.1972.36.4.0386 / J Neurosurg / Altered norepinephrine metabolism following experimental spinal cord injury. I. Relationship to haemorrhagic necrosis and post wounding neurological deficits. by Osterholm (1972)
10.1007/BF01406765 / Acta Neurochir / Experimental investigation on the control of spinal cord circulation. IV. The effect of spinal or cerebral compression on the blood flow of the spinal cord. by Palleske (1970)
{'key': 'b29', 'series-title': 'Acta Neuropathol (Berl)', 'first-page': '183', 'article-title': 'Studies on vascular permeability changes in experimental brain concussion. I. Distribution of circulating fluorescent indicators in brain and cervical cord after sudden mechanical loading of the brain.', 'volume': '11', 'author': 'Rinder', 'year': '1968'} / Acta Neuropathol (Berl) / Studies on vascular permeability changes in experimental brain concussion. I. Distribution of circulating fluorescent indicators in brain and cervical cord after sudden mechanical loading of the brain. by Rinder (1968)
{'key': 'b30', 'series-title': 'Scand J Lab Clin Invest', 'first-page': 'C', 'article-title': 'Fine structure study of brain swelling induced by mechanical injury.', 'volume': 'XIV', 'author': 'Schutta', 'year': '1968'} / Scand J Lab Clin Invest / Fine structure study of brain swelling induced by mechanical injury. by Schutta (1968)
10.1097/00005072-196610000-00004 / J Neuropathol Exp Neurol / Selective vulnerability of the blood-brain barrier in chemically induced lesions. by Steinwall (1966)
{'key': 'b32', 'series-title': 'Spinal Cord Compression: Mechanism of Paralysis and Treatment.', 'author': 'Tarlov', 'year': '1957'} / Spinal Cord Compression: Mechanism of Paralysis and Treatment. by Tarlov (1957)
10.1007/BF00586835 / Pflügers Arch / Post-ischemic reactive hyperemia of the isolated perfused brain of the dog. by Zimmer (1971)

Dates

Type	When
Created	16 years, 3 months ago (May 7, 2009, 11:07 a.m.)
Deposited	3 years, 1 month ago (July 10, 2022, 8:26 p.m.)
Indexed	1 year, 6 months ago (Feb. 20, 2024, 6:02 p.m.)
Issued	50 years, 7 months ago (Feb. 1, 1975)
Published	50 years, 7 months ago (Feb. 1, 1975)
Published Print	50 years, 7 months ago (Feb. 1, 1975)

Funders 0

None

BibTeX

@article{Griffiths_1975, title={Vasogenic edema following acute and chronic spinal cord compression in the dog}, volume={42}, ISSN={0022-3085}, url={http://dx.doi.org/10.3171/jns.1975.42.2.0155}, DOI={10.3171/jns.1975.42.2.0155}, number={2}, journal={Journal of Neurosurgery}, publisher={Journal of Neurosurgery Publishing Group (JNSPG)}, author={Griffiths, Ian R.}, year={1975}, month=feb, pages={155–165} }

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