DOI: 10.2337/diacare.26.12.3237. In Utero Dietary Exposures and Risk of Islet Autoimmunity in Children

In Utero Dietary Exposures and Risk of Islet Autoimmunity in Children

10.2337/diacare.26.12.3237

Crossref journal-article

American Diabetes Association

Diabetes Care (1167)

Abstract

OBJECTIVE—The goal of this study was to examine whether maternal dietary intake of vitamin D, ω-3 fatty acids, and ω-6 fatty acids during pregnancy is associated with the appearance of islet autoimmunity (IA) in offspring. RESEARCH DESIGN AND METHODS—The Diabetes Autoimmunity Study in the Young (DAISY) is recruiting at birth and following children at increased risk for type 1 diabetes, as determined by HLA-DR genotype or by family history of type 1 diabetes. A total of 233 mothers of newly recruited DAISY subjects were asked to recall their intake of food and nutritional supplements during the third trimester of pregnancy using the Willett food frequency questionnaire. Children were followed for an average of 4 years (range 0.8–7.3 years) for the appearance of insulin, GAD65, and IA-2 autoantibodies. Sixteen children developed at least one autoantibody during this period. Unadjusted and adjusted hazard ratios (HRs) for the development of IA were estimated with survival analysis using a Weibull distribution. RESULTS—Maternal intake of vitamin D via food was significantly associated with a decreased risk of IA appearance in offspring, independent of HLA genotype, family history of type 1 diabetes, presence of gestational diabetes mellitus, and ethnicity (adjusted HR = 0.37; 95% CI 0.17–0.78). Vitamin D intake via supplements, ω-3 fatty acids, and ω-6 fatty acids intake during pregnancy were not associated with appearance of IA in offspring. CONCLUSIONS—Our findings suggest that maternal intake of vitamin D through food during pregnancy may have a protective effect on the appearance of IA in offspring.

Bibliography

Fronczak, C. M., BaroÌn, A. E., Chase, H. P., Ross, C., Brady, H. L., Hoffman, M., Eisenbarth, G. S., Rewers, M., & Norris, J. M. (2003). In Utero Dietary Exposures and Risk of Islet Autoimmunity in Children. Diabetes Care, 26(12), 3237â3242.

Authors 9

Carolyn M. Fronczak (first)
Anna E. Barón (additional)
H. Peter Chase (additional)
Colleen Ross (additional)
Heather L. Brady (additional)
Michelle Hoffman (additional)
George S. Eisenbarth (additional)
Marian Rewers (additional)
Jill M. Norris (additional)

References 40 Referenced 171

Dates

Type	When
Created	18 years, 5 months ago (March 5, 2007, 5:51 p.m.)
Deposited	3 years, 5 months ago (March 12, 2022, 9:53 a.m.)
Indexed	3 months, 1 week ago (May 21, 2025, 12:44 a.m.)
Issued	21 years, 8 months ago (Dec. 1, 2003)
Published	21 years, 8 months ago (Dec. 1, 2003)
Published Print	21 years, 8 months ago (Dec. 1, 2003)

Funders 0

None

BibTeX

@article{Fronczak_2003, title={In Utero Dietary Exposures and Risk of Islet Autoimmunity in Children}, volume={26}, ISSN={1935-5548}, url={http://dx.doi.org/10.2337/diacare.26.12.3237}, DOI={10.2337/diacare.26.12.3237}, number={12}, journal={Diabetes Care}, publisher={American Diabetes Association}, author={Fronczak, Carolyn M. and Barón, Anna E. and Chase, H. Peter and Ross, Colleen and Brady, Heather L. and Hoffman, Michelle and Eisenbarth, George S. and Rewers, Marian and Norris, Jill M.}, year={2003}, month=dec, pages={3237–3242} }

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  "abstract": "<jats:p>OBJECTIVE\u2014The goal of this study was to examine whether maternal dietary intake of vitamin D, \u03c9-3 fatty acids, and \u03c9-6 fatty acids during pregnancy is associated with the appearance of islet autoimmunity (IA) in offspring.</jats:p>\n               <jats:p>RESEARCH DESIGN AND METHODS\u2014The Diabetes Autoimmunity Study in the Young (DAISY) is recruiting at birth and following children at increased risk for type 1 diabetes, as determined by HLA-DR genotype or by family history of type 1 diabetes. A total of 233 mothers of newly recruited DAISY subjects were asked to recall their intake of food and nutritional supplements during the third trimester of pregnancy using the Willett food frequency questionnaire. Children were followed for an average of 4 years (range 0.8\u20137.3 years) for the appearance of insulin, GAD65, and IA-2 autoantibodies. Sixteen children developed at least one autoantibody during this period. Unadjusted and adjusted hazard ratios (HRs) for the development of IA were estimated with survival analysis using a Weibull distribution.</jats:p>\n               <jats:p>RESULTS\u2014Maternal intake of vitamin D via food was significantly associated with a decreased risk of IA appearance in offspring, independent of HLA genotype, family history of type 1 diabetes, presence of gestational diabetes mellitus, and ethnicity (adjusted HR = 0.37; 95% CI 0.17\u20130.78). Vitamin D intake via supplements, \u03c9-3 fatty acids, and \u03c9-6 fatty acids intake during pregnancy were not associated with appearance of IA in offspring.</jats:p>\n               <jats:p>CONCLUSIONS\u2014Our findings suggest that maternal intake of vitamin D through food during pregnancy may have a protective effect on the appearance of IA in offspring.</jats:p>",
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      "DOI": "10.1007/BF02221682"
    },
    {
      "key": "2022031214525681300_R2",
      "doi-asserted-by": "crossref",
      "unstructured": "Couper JJ: Environmental triggers of type 1 diabetes. J Paediatr Child Health\u200837:218\u2013220, 2001",
      "DOI": "10.1046/j.1440-1754.2001.00658.x"
    },
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      "unstructured": "Bodansky HJ, Staines A, Stephenson C, Haigh D, Cartwright R: Evidence for an environmental effect in the etiology of insulin dependent diabetes in a transmigratory population. BMJ\u2008304:1020\u20131022, 1992",
      "DOI": "10.1136/bmj.304.6833.1020"
    },
    {
      "key": "2022031214525681300_R4",
      "doi-asserted-by": "crossref",
      "unstructured": "Onkamo P, Vaananen S, Karvonen M, Tuomilehto J: Worldwide increase in incidence of type I diabetes: the analysis of the data on published incidence trends. Diabetologia\u200842:1395\u20131403, 1999",
      "DOI": "10.1007/s001250051309"
    },
    {
      "key": "2022031214525681300_R5",
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      "unstructured": "Kimpimaki T, Kupila A, Hamalainen AM, Kukko M, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M: The first signs of \u03b2-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab\u200886:4782\u20134788, 2001",
      "DOI": "10.1210/jcem.86.10.7907"
    },
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      "unstructured": "Ziegler AG, Hillebrand B, Rabl W, Mayrhofer M, Hummel M, Mollenhauer U, Vordemann J, Lenz A, Standl E: On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia\u200836:402\u2013408, 1993",
      "DOI": "10.1007/BF00402275"
    },
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      "doi-asserted-by": "crossref",
      "unstructured": "Colman PG, Steele C, Couper JJ, Beresford SJ, Powell T, Kewming K, Pollard A, Gellert S, Tait B, Honeyman M, Harrison LC: Islet autoimmunity in infants with a type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia\u200843:203\u2013209, 2000",
      "DOI": "10.1007/s001250050030"
    },
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      "unstructured": "Yu J, Yu L, Bugawan TL, Erlich HA, Barriga K, Hoffman M, Rewers M, Eisenbarth GS: Transient antiislet autoantibodies: infrequent occurrence and lack of association with \u201cgenetic\u201d risk factors. J Clin Endocrinol Metab\u200885:2421\u20132428, 2000",
      "DOI": "10.1210/jc.85.7.2421"
    },
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      "doi-asserted-by": "crossref",
      "unstructured": "Kukreja A, Maclaren NK: Autoimmunity and diabetes. J Clin Endocrinol Metab\u200884:4371\u20134378, 1999",
      "DOI": "10.1210/jcem.84.12.6212"
    },
    {
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      "DOI": "10.1007/BF03349999"
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      "key": "2022031214525681300_R13",
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      "doi-asserted-by": "crossref",
      "unstructured": "EURODIAB Substudy 2 Study Group: Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. Diabetologia\u200842:51\u201354, 1999",
      "DOI": "10.1007/s001250051112"
    },
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      "key": "2022031214525681300_R20",
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      "unstructured": "Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM: Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet\u2008358:1500\u20131503, 2001",
      "DOI": "10.1016/S0140-6736(01)06580-1"
    },
    {
      "key": "2022031214525681300_R21",
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      "unstructured": "Stene LC, Ulriksen J, Magnus P, Joner G: Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia\u200843:1093\u20131098, 2000",
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    },
    {
      "key": "2022031214525681300_R22",
      "doi-asserted-by": "crossref",
      "unstructured": "Menser MA, Forrest JM, Bransby RD: Rubella infection and diabetes mellitus. Lancet\u20081:57\u201360, 1978",
      "DOI": "10.1016/S0140-6736(78)90001-6"
    },
    {
      "key": "2022031214525681300_R23",
      "doi-asserted-by": "crossref",
      "unstructured": "Greeley SA, Katsumata M, Yu L, Eisenbarth GS, Moore DJ, Goodarzi H, Barker CF, Naji A, Noorchashm H: Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat Med\u20088:399\u2013402, 2002",
      "DOI": "10.1038/nm0402-399"
    },
    {
      "key": "2022031214525681300_R24",
      "doi-asserted-by": "crossref",
      "unstructured": "Lindberg B, Ivarsson SA, Landin-Olsson M, Sundkvist G, Svanberg L, Lernmark A: Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia\u200842:181\u2013187, 1999",
      "DOI": "10.1007/s001250051137"
    },
    {
      "key": "2022031214525681300_R25",
      "doi-asserted-by": "crossref",
      "unstructured": "Zeghoud F, Vervel C, Guillozo H, Walrant-Debray O, Boutignon H, Garabedian M: Subclinical vitamin D deficiency in neonates: definition and response to vitamin D supplements. Am J Clin Nutr\u200865:771\u2013778, 1997",
      "DOI": "10.1093/ajcn/65.3.771"
    },
    {
      "key": "2022031214525681300_R26",
      "doi-asserted-by": "crossref",
      "unstructured": "Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS: Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr\u2008109:328\u2013334, 1986",
      "DOI": "10.1016/S0022-3476(86)80396-1"
    },
    {
      "key": "2022031214525681300_R27",
      "doi-asserted-by": "crossref",
      "unstructured": "Connor WE, Lowensohn R, Hatcher L: Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. Lipids\u200831:S183\u2013S187, 1996",
      "DOI": "10.1007/BF02637073"
    },
    {
      "key": "2022031214525681300_R28",
      "doi-asserted-by": "crossref",
      "unstructured": "EURODIAB ACE Study Group: Variation and trends in incidence of childhood diabetes in Europe. Lancet\u2008355:873\u2013876, 2000",
      "DOI": "10.1016/S0140-6736(99)07125-1"
    },
    {
      "key": "2022031214525681300_R29",
      "doi-asserted-by": "crossref",
      "unstructured": "Rewers M, Bugawan TL, Norris JM, Blair A, Beaty B, Hoffman M, McDuffie RS Jr, Hamman RF, Klingensmith G, Eisenbarth GS, Erlich HA: Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia\u200839:807\u2013812, 1996",
      "DOI": "10.1007/s001250050514"
    },
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      "unstructured": "Iso H, Rexrode KM, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Hennekens CH, Willett WC: Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA\u2008285:304\u2013312, 2001",
      "DOI": "10.1001/jama.285.3.304"
    },
    {
      "key": "2022031214525681300_R31",
      "doi-asserted-by": "crossref",
      "unstructured": "Yu L, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, Eisenbarth GS: Early expression of anti-insulin autoantibodies of man and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A\u200897:1701\u20131706, 2000",
      "DOI": "10.1073/pnas.040556697"
    },
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      "key": "2022031214525681300_R32",
      "doi-asserted-by": "crossref",
      "unstructured": "Yu L, Rewers M, Gianani R, Kawasaki E, Zhang Y, Verge C, Chase P, Klingensmith G, Erlich H, Norris J, Eisenbarth GS: Antiislet autoantibodies usually develop sequentially rather than simultaneously. J Clin Endocrinol Metab\u200881:4264\u20134267, 1996",
      "DOI": "10.1210/jcem.81.12.8954025"
    },
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      "key": "2022031214525681300_R34",
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      "unstructured": "Collett D: Modeling Survival Data in Medical Research. London, Chapman and Hall, 1994",
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      "unstructured": "Suitor CJ, Gardner J, Willett WC: A comparison of food frequency and diet recall methods in studies of nutrient intake of low-income pregnant women. J Am Diet Assoc\u200889:1786\u20131794, 1989",
      "DOI": "10.1016/S0002-8223(21)02469-X"
    },
    {
      "key": "2022031214525681300_R36",
      "doi-asserted-by": "crossref",
      "unstructured": "Greeley S, Storbakken L, Magel R: Use of a modified food frequency questionnaire during pregnancy. J Am Coll Nutr\u200811:728\u2013734, 1992",
      "DOI": "10.1080/07315724.1992.10718274"
    },
    {
      "key": "2022031214525681300_R37",
      "unstructured": "Robinson S, Godfrey K, Osmond C, Cox V, Barker D: Evaluation of a food frequency questionnaire used to assess nutrient intakes in pregnant women. Eur J Clin Nutr\u200850:302\u2013308, 1996"
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      "key": "2022031214525681300_R38",
      "doi-asserted-by": "crossref",
      "unstructured": "Brown JE, Buzzard IM, Jacobs DR Jr, Hannan PJ, Kushi LH, Barosso GM, Schmid LA: A food frequency questionnaire can detect pregnancy-related changes in diet. J Am Diet Assoc\u200896:262\u2013266, 1996",
      "DOI": "10.1016/S0002-8223(96)00078-8"
    },
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      "unstructured": "Erkkola M, Karppinen M, Javanainen J, Rasanen L, Knip M, Virtanen SM: Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women. Am J Epidemiol\u2008154:466\u2013476, 2001",
      "DOI": "10.1093/aje/154.5.466"
    },
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      "key": "2022031214525681300_R40",
      "unstructured": "Brady HL, Ross C, Rewers M, Sokol R, Norris JM: Plasma vitamin D status and development of \u03b2-cell autoimmunity in young children (Abstract). Diabetes\u200851(Suppl. 2):A220, 2002"
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  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        12,
        1
      ]
    ]
  },
  "references-count": 40,
  "journal-issue": {
    "issue": "12",
    "published-print": {
      "date-parts": [
        [
          2003,
          12,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.2337/diacare.26.12.3237",
  "relation": {},
  "ISSN": [
    "0149-5992",
    "1935-5548"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2003,
        12,
        1
      ]
    ]
  }
}